Selective digestive decontamination with oral colistin plus gentamicin for persistent bacteraemia caused by non-carbapenemase-producing carbapenem-resistant <i>Klebsiella pneumoniae</i> in a neutropenic patient
Journal
JAC-Antimicrobial Resistance
ISSN
2632-1823
Date Issued
2021
Author(s)
Maria Spencer-Sandino
Roberto Riquelme-Neira
William C Shropshire
An Q Dinh
Gerardo González-Rocha
Paulina González-Muñoz
Alejandra Vera-Leiva
Blake Hanson
Cesar A Arias
Type
Resource Types::text::journal::journal article
DOI
URL
Abstract
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Carbapenem-resistant Klebsiella pneumoniae (CRKp) have become an increasing public health problem worldwide. While most CRKp around the world harbour a carbapenemase enzyme, the clinical relevance of non-carbapenemase-producing CRKp (non-CP-CRKp) is increasingly recognized. Selective digestive decontamination (SDD) has been proven successful as a decolonization strategy for patients colonized with Gram-negatives in the ICU. However, it is not regularly used to treat invasive infections.</jats:p> </jats:sec> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>To report the use of SDD as a useful strategy for managing recalcitrant CRKp bloodstream infections.</jats:p> </jats:sec> <jats:sec> <jats:title>Patients and methods</jats:title> <jats:p>We present a neutropenic patient with a recalcitrant bloodstream infection with non-CP-CRKp treated with SDD. Besides, genomic analyses of five isolates of non-CP-CRKp was performed.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>After 11 days of SDD treatment with oral colistin and gentamicin, bacteraemia was successfully eradicated. Genomic analysis indicates a fully carbapenem-resistant phenotype evolved in vivo and suggests that the mechanism of carbapenem resistance in our strains relates to gene amplification of narrow-spectrum β-lactamases.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Our report highlights that SDD might be a useful strategy to manage CRKp bloodstream infections, when intestinal translocation is the likely source of the bacteraemia. In addition, the development of a resistant phenotype during therapy is worrisome as therapies directed against these organisms are likely to favour the amplification process.</jats:p> </jats:sec>