Abnormal nodal and global network organization in resting state functional MRI from subjects with the 22q11 deletion syndrome
Journal
Scientific Reports
ISSN
2045-2322
Date Issued
2021
Author(s)
Teuntje A. D. Pelgrim
Matthijs G. Bossong
Analía Cuiza
Luz María Alliende
Carlos Mena
Angeles Tepper
Juan Pablo Ramirez-Mahaluf
Barbara Iruretagoyena
Claudia Ornstein
Rosemarie Fritsch
Juan Pablo Cruz
Cristian Tejos
Nicolas Crossley
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:title>Abstract</jats:title><jats:p>The 22q11 deletion syndrome is a genetic disorder associated with a high risk of developing psychosis, and is therefore considered a neurodevelopmental model for studying the pathogenesis of schizophrenia. Studies have shown that localized abnormal functional brain connectivity is present in 22q11 deletion syndrome like in schizophrenia. However, it is less clear whether these abnormal cortical interactions lead to global or regional network disorganization as seen in schizophrenia. We analyzed from a graph-theory perspective fMRI data from 40 22q11 deletion syndrome patients and 67 healthy controls, and reconstructed functional networks from 105 brain regions. Between-group differences were examined by evaluating edge-wise strength and graph theoretical metrics of local (weighted degree, nodal efficiency, nodal local efficiency) and global topological properties (modularity, local and global efficiency). Connectivity strength was globally reduced in patients, driven by a large network comprising 147 reduced connections. The 22q11 deletion syndrome network presented with abnormal local topological properties, with decreased local efficiency and reductions in weighted degree particularly in hub nodes. We found evidence for abnormal integration but intact segregation of the 22q11 deletion syndrome network. Results suggest that 22q11 deletion syndrome patients present with similar aberrant local network organization as seen in schizophrenia, and this network configuration might represent a vulnerability factor to psychosis.</jats:p>
Cite this document
Pelgrim, T. A. D., Bossong, M. G., Cuiza, A., Alliende, L. M., Mena, C., Tepper, A., Ramirez-Mahaluf, J. P., Iruretagoyena, B., Ornstein, C., Fritsch, R., Cruz, J. P., Tejos, C., Repetto, G., & Crossley, N. (2021). Abnormal nodal and global network organization in resting state functional MRI from subjects with the 22q11 deletion syndrome. Scientific Reports, 11(1), 21623. https://doi.org/10.1038/s41598-021-00873-8
Dataset(s)
Dataset - Data for Pelgrim et al. (2021) Scientific Reports
Subjects
brain
;
connectivity
;
schizophrenia
;
dysconnectivity
;
connectome
;
architecture
;
dysfunction
;
modularity
;
disorders
;
childhood
;
22q11 deletion syndrome
;
adult
;
case-control studies
;
connectome
;
female
;
humans
;
image processing, computer-assisted
;
magnetic resonance imaging
;
male
;
nerve net
;
neural pathways
;
rest
;
young adult
;
adult
;
case control study
;
chromosome deletion 22q11
;
connectome
;
female
;
genetics
;
human
;
image processing
;
male
;
nerve cell network
;
nerve tract
;
nuclear magnetic resonance imaging
;
pathology
;
pathophysiology
;
physiology
;
procedures
;
rest
;
young adult