Norovirus: Facts and Reflections from Past, Present, and Future
Journal
Viruses
ISSN
1999-4915
Date Issued
2021
Author(s)
David O. Matson
Shai Ashkenazi
Sergio George
Miguel O’Ryan
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Human Norovirus is currently the main viral cause of acute gastroenteritis (AGEs) in most countries worldwide. Nearly 50 years after the discovery of the “Norwalk virus” by Kapikian and colleagues, the scientific and medical community continue to generate new knowledge on the full biological and disease spectrum of Norovirus infection. Nevertheless, several areas remain incompletely understood due to the serious constraints to effectively replicate and propagate the virus. Here, we present a narrated historic perspective and summarize our current knowledge, including insights and reflections on current points of interest for a broad medical community, including clinical and molecular epidemiology, viral–host–microbiota interactions, antivirals, and vaccine prototypes. We also include a reflection on the present and future impacts of the COVID-19 pandemic on Norovirus infection and disease.</jats:p>
Subjects
norovirus
;
epidemiology
;
prevention
;
vaccine
;
antiviral agents
;
caliciviridae infections
;
covid-19
;
gastroenteritis
;
gastrointestinal microbiome
;
host-pathogen interactions
;
humans
;
norovirus
;
sars-cov-2
;
viral vaccines
;
antivirus agent
;
immunoglobulin a
;
vaccine
;
virus vaccine
;
abdominal pain
;
acute gastroenteritis
;
bacteroidetes
;
cd8+ t lymphocyte
;
clostridia
;
coronavirus disease 2019
;
day care
;
diarrhea
;
enteropathogenic escherichia coli
;
enzyme linked immunosorbent assay
;
escherichia coli
;
faecalibacterium
;
feces analysis
;
genetic variability
;
genotype
;
headache
;
heat stress
;
hospitalization
;
host microbe interaction
;
immune response
;
inflammatory bowel disease
;
innate immunity
;
intestine flora
;
lactobacillus
;
malaise
;
norovirus
;
pandemic
;
proteobacteria
;
review
;
rotavirus
;
ruminococcus
;
seroconversion
;
vaccination
;
virus detection
;
virus replication
;
virus shedding
;
vomiting
;
zika virus
;
calicivirus infection
;
gastroenteritis
;
genetics
;
host pathogen interaction
;
human
;
immunology
;
microbiology
;
norovirus
;
physiology
;
prevention and control
;
virology