Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease
Journal
Frontiers in Aging Neuroscience
ISSN
1663-4365
Date Issued
2022
Author(s)
Michael J. Hurley
Claudio Urra
B. Maximiliano Garduno
Agostino Bruno
Allison Kimbell
Brent Wilkinson
Cristina Marino-Buslje
Pedro F. Aburto
Elie Poulin
Rodrigo A. Vasquez
Robert Deacon
Ariel Avila
Francisco Altimiras
Peter Whitney Vanderklish
Guido Zampieri
Claudio Angione
Gabriele Constantino
Todd C. Holmes
Marcelo P. Coba
Xiangmin Xu
Patricia Cogram
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>The degu (<jats:italic>Octodon degus</jats:italic>) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer's disease including neuroinflammation, hyperphosphorylated tau and amyloid plaques, together with other co-morbidities associated with aging such as macular degeneration, cataracts, alterations in circadian rhythm, diabetes and atherosclerosis. Here we report the whole-genome sequencing and analysis of the degu genome, which revealed unique features and molecular adaptations consistent with aging and Alzheimer's disease. We identified single nucleotide polymorphisms in genes associated with Alzheimer's disease including a novel apolipoprotein E (<jats:italic>Apoe</jats:italic>) gene variant that correlated with an increase in amyloid plaques in brain and modified the <jats:italic>in silico</jats:italic> predicted degu APOE protein structure and functionality. The reported genome of an unconventional long-lived animal model of aging and Alzheimer's disease offers the opportunity for understanding molecular pathways involved in aging and should help advance biomedical research into treatments for Alzheimer's disease.</jats:p>
Cite this document
Hurley, M. J., Urra, C., Garduno, B. M., Bruno, A., Kimbell, A., Wilkinson, B., Marino-Buslje, C., Ezquer, M., Ezquer, F., Aburto, P. F., Poulin, E., Vasquez, R. A., Deacon, R., Avila, A., Altimiras, F., Whitney Vanderklish, P., Zampieri, G., Angione, C., Constantino, G., … Cogram, P. (2022). Genome sequencing variations in the octodon degus, an unconventional natural model of aging and alzheimer’s disease. Frontiers in Aging Neuroscience, 14, 894994. https://doi.org/10.3389/fnagi.2022.894994
Dataset(s)
Material Suplementario - Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease
Subjects
growth-factor-i
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pathology
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insulin
;
metabolism
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neurons
;
dysregulation
;
recognition
;
variants
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dementia
;
genetics
;
apolipoprotein e
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fat droplet
;
somatomedin c
;
x box binding protein 1
;
aging
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alzheimer disease
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animal experiment
;
animal model
;
animal tissue
;
article
;
controlled study
;
down regulation
;
embryo
;
gene mapping
;
gene mutation
;
genetic association
;
genetic variation
;
human
;
human cell
;
indel mutation
;
male
;
molecular model
;
mouse
;
nerve cell differentiation
;
nonhuman
;
single nucleotide polymorphism
;
upregulation
;
whole genome sequencing