Multimodal neurocognitive markers of naturalistic discourse typify diverse neurodegenerative diseases
Journal
Cerebral Cortex
ISSN
1047-3211
1460-2199
Date Issued
2021
Author(s)
Agustina Birba
Sol Fittipaldi
Judith C Cediel Escobar
Cecilia Gonzalez Campo
Agustina Legaz
Agostina Galiani
Mariano N Díaz Rivera
Miquel Martorell Caro
Florencia Alifano
Stefanie D Piña-Escudero
Juan Felipe Cardona
Alejandra Neely
Gonzalo Forno
Mariela Carpinella
Cecilia Serrano
Lucas Sedeño
Agustín Ibáñez
Adolfo M García
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:title>Abstract</jats:title>
<jats:p>Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four naturalistic stories, highlighting action, nonaction, social, and nonsocial events, in Parkinson’s disease (PD) and behavioral variant frontotemporal dementia (bvFTD) relative to Alzheimer’s disease patients and healthy controls. Text-specific correlates were evaluated via voxel-based morphometry, spatial (fMRI), and temporal (hd-EEG) functional connectivity. PD patients presented action–text deficits related to the volume of action–observation regions, connectivity across motor-related and multimodal-semantic hubs, and frontal hd-EEG hypoconnectivity. BvFTD patients exhibited social–text deficits, associated with atrophy and spatial connectivity patterns along social-network hubs, alongside right frontotemporal hd-EEG hypoconnectivity. Alzheimer’s disease patients showed impairments in all stories, widespread atrophy and spatial connectivity patterns, and heightened occipitotemporal hd-EEG connectivity. Our framework revealed disease-specific signatures across behavioral, neuroanatomical, and neurofunctional dimensions, highlighting the sensitivity and specificity of a single naturalistic task. This investigation opens a translational agenda combining ecological approaches and multimodal cognitive neuroscience for the study of neurodegeneration.</jats:p>
<jats:p>Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four naturalistic stories, highlighting action, nonaction, social, and nonsocial events, in Parkinson’s disease (PD) and behavioral variant frontotemporal dementia (bvFTD) relative to Alzheimer’s disease patients and healthy controls. Text-specific correlates were evaluated via voxel-based morphometry, spatial (fMRI), and temporal (hd-EEG) functional connectivity. PD patients presented action–text deficits related to the volume of action–observation regions, connectivity across motor-related and multimodal-semantic hubs, and frontal hd-EEG hypoconnectivity. BvFTD patients exhibited social–text deficits, associated with atrophy and spatial connectivity patterns along social-network hubs, alongside right frontotemporal hd-EEG hypoconnectivity. Alzheimer’s disease patients showed impairments in all stories, widespread atrophy and spatial connectivity patterns, and heightened occipitotemporal hd-EEG connectivity. Our framework revealed disease-specific signatures across behavioral, neuroanatomical, and neurofunctional dimensions, highlighting the sensitivity and specificity of a single naturalistic task. This investigation opens a translational agenda combining ecological approaches and multimodal cognitive neuroscience for the study of neurodegeneration.</jats:p>
Subjects
embodied cognition
;
fmri/hd-eeg functional connectivity
;
naturalistic texts
;
neurodegeneration
;
voxel-based morphometry
;
alzheimer disease
;
atrophy
;
biomarkers
;
brain
;
frontotemporal dementia
;
humans
;
magnetic resonance imaging
;
neurodegenerative diseases
;
neuropsychological tests
;
biological marker
;
action observation network
;
alzheimer disease
;
article
;
brain atrophy
;
cognitive neuroscience
;
comprehension
;
degenerative disease
;
electroencephalogram
;
frontal variant frontotemporal dementia
;
functional connectivity
;
functional magnetic resonance imaging
;
human
;
nerve degeneration
;
neuropsychological assessment
;
parkinson disease
;
sensitivity and specificity
;
social network
;
voxel based morphometry
;
atrophy
;
brain
;
degenerative disease
;
diagnostic imaging
;
frontotemporal dementia
;
neuropsychological test
;
nuclear magnetic resonance imaging
;
pathology