Project Title
Unraveling the differences between mild and severe hantavirus infected patients: delineating mechanisms to propose novel therapies
Partner Organisations
Internal ID
1201240
Principal Investigator
Start Date
2020
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Item type:Publication, NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2<jats:sec> <jats:title /> <jats:p>The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1, MERS-CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic variants in NPC1, which encodes for the endo-lysosomal Niemann-Pick type C1 protein, restricts the host-range of viruses in bats and susceptibility to infections in humans. Lack of NPC1 and its pharmacological suppression inhibits many viral infections including SARS-CoV-1 and Type I Feline Coronavirus Infection. Antiviral effects of NPC1-inhibiting drugs for COVID-19 treatment should be explored.</jats:p> </jats:sec>2Scopus© Citations 11 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, An international, interlaboratory ring trial confirms the feasibility of an extraction-less “direct” RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples(2022)3Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Viral shedding and viraemia of Andes virus during acute hantavirus infection: a prospective study(2024)10Scopus© Citations 45 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Hantavirus in humans: a review of clinical aspects and management(2023); 79Scopus© Citations 195 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparison of VSV Pseudovirus and Focus Reduction Neutralization Assays for Measurement of Anti-Andes orthohantavirus Neutralizing Antibodies in Patient Samples(2020); 4Scopus© Citations 10 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Targeted high volume hemofiltration could avoid extracorporeal membrane oxygenation in some patients with severe Hantavirus cardiopulmonary syndrome(2021); 1Scopus© Citations 15 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of the Immune Response Induced by CoronaVac 28-Day Schedule Vaccination in a Healthy Population Group(2022)23Scopus© Citations 19 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19(2022)Scopus© Citations 204 11 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Proteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortality(2021); ; 27Scopus© Citations 9 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker(2023); ; ; Hantavirus cardiopulmonary syndrome (HCPS) is a severe respiratory illness primarily associated with microvascular endothelial changes, particularly in the lungs. However, the role of the pulmonary epithelium in HCPS pathogenesis remains unclear. This study explores the potential of soluble Receptors for Advanced Glycation End-products (sRAGE) as a biomarker for assessing pulmonary epithelial damage in severe HCPS, challenging the prevailing view that endothelial dysfunction is the sole driver of this syndrome. We conducted a cross-sectional study on critically ill HCPS patients, categorizing them into mild HCPS, severe HCPS, and negative control groups. Plasma sRAGE levels were measured, revealing significant differences between the severe HCPS group and controls. Our findings suggest that sRAGE holds promise as an indicator of pulmonary epithelial injury in HCPS and may aid in tracking disease progression and guiding therapeutic strategies. This study brings clarity on the importance of investigating the pulmonary epithelium’s role in HCPS pathogenesis, offering potential avenues for enhanced diagnostic precision and support in this critical public health concern.1Scopus© Citations 6