NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2

Journal
Current Molecular Medicine
ISSN
1566-5240
Date Issued
2021
Author(s)
Type
Resource Types::text::journal::journal article
Scopus ID
2-s2.0-85103608252
WoS ID
WOS:000647674200002
DOI
URL
URL Institutional Repository
Abstract
<jats:sec>
<jats:title />
<jats:p>The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1,
MERS-CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic
variants in NPC1, which encodes for the endo-lysosomal Niemann-Pick type C1 protein, restricts
the host-range of viruses in bats and susceptibility to infections in humans. Lack of NPC1 and its
pharmacological suppression inhibits many viral infections including SARS-CoV-1 and Type I Feline
Coronavirus Infection. Antiviral effects of NPC1-inhibiting drugs for COVID-19 treatment should be
explored.</jats:p>
</jats:sec>
Project(s)
Subjects
covid-19

; 

sars-cov-2

; 

niemann-pick c1

; 

modifier gene

; 

drug repurposing

; 

virus

; 

infection

; 

antiviral agents

; 

covid-19

; 

drug repositioning

; 

humans

; 

intracellular signaling peptides and proteins

; 

sars-cov-2

; 

severity of illness index

; 

virus internalization

; 

1 benzylpiperazine derivative

; 

amphophile

; 

angiotensin converting enzyme 2

; 

antisense oligonucleotide

; 

clomifene

; 

diamide

; 

hydroxychloroquine

; 

npc intracellular cholesterol transporter 1

; 

terconazole

; 

antivirus agent

; 

npc1 protein, human

; 

signal peptide

; 

antiviral activity

; 

article

; 

chikungunya virus

; 

cholesterol metabolism

; 

coronavirus disease 2019

; 

dengue virus

; 

disease severity

; 

drug repositioning

; 

ebolavirus

; 

endocytosis

; 

feline coronavirus

; 

filovirus

; 

gene silencing

; 

genetic susceptibility

; 

hepatitis c

; 

host range

; 

human

; 

human immunodeficiency virus

; 

lysosome

; 

lysosome storage disease

; 

middle east respiratory syndrome coronavirus

; 

modifier gene

; 

multiple sclerosis

; 

niemann pick disease

; 

nonhuman

; 

plague

; 

protein function

; 

severe acute respiratory syndrome coronavirus 2

; 

single nucleotide polymorphism

; 

virus entry

; 

virus infection

; 

west nile virus

; 

zika fever

; 

zika virus

; 

drug therapy

; 

pathophysiology

; 

physiology

; 

severity of illness index

; 

virology

; 

virus entry