Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis
Journal
Biomolecules
ISSN
2218-273X
Date Issued
2019
Author(s)
America Campos
Renato Burgos-Ravanal
Maria Fernanda Gonzalez
Ricardo Huilcaman
Andrew Quest
Type
Resource Types::text::journal::journal article
Abstract
<jats:p>Caveolin-1 (CAV1) is a scaffolding protein with a controversial role in cancer. This review will initially discuss earlier studies focused on the role as a tumor suppressor before elaborating subsequently on those relating to function of the protein as a promoter of metastasis. Different mechanisms are summarized illustrating how CAV1 promotes such traits upon expression in cancer cells (intrinsic mechanisms). More recently, it has become apparent that CAV1 is also a secreted protein that can be included into exosomes where it plays a significant role in determining cargo composition. Thus, we will also discuss how CAV1 containing exosomes from metastatic cells promote malignant traits in more benign recipient cells (extrinsic mechanisms). This ability appears, at least in part, attributable to the transfer of specific cargos present due to CAV1 rather than the transfer of CAV1 itself. The evolution of how our perception of CAV1 function has changed since its discovery is summarized graphically in a time line figure.</jats:p>
Cite this document
Campos, A., Burgos-Ravanal, R., González, M., Huilcaman, R., Lobos González, L., & Quest, A. (2019). Cell intrinsic and extrinsic mechanisms of caveolin-1-enhanced metastasis. Biomolecules, 9(8), 314. https://doi.org/10.3390/biom9080314
Subjects
caveolae
;
cholesterol transport
;
tumor suppressor
;
metastasis promoter
;
exosomes
;
caveolin 1
;
exosomes
;
gene expression regulation, neoplastic
;
humans
;
neoplasm metastasis
;
signal transduction
;
b raf kinase
;
beta catenin
;
beta1 integrin
;
caspase 8
;
caveolin 1
;
caveolin 1 alpha
;
caveolin 1 beta
;
cholesterol
;
cyclin d1
;
cyclooxygenase 2
;
endothelial nitric oxide synthase
;
epidermal growth factor receptor
;
fibronectin
;
focal adhesion kinase
;
gelatinase a
;
gelatinase b
;
high mobility group b1 protein
;
immunoglobulin enhancer binding protein
;
interstitial collagenase
;
mammalian target of rapamycin
;
matrix metalloproteinase
;
protein c fos
;
protein kinase c
;
protein tyrosine kinase
;
rho kinase
;
transcription factor snail
;
transcription factor twist
;
unclassified drug
;
unindexed drug
;
uvomorulin
;
vimentin
;
cav1 protein, human
;
caveolin 1
;
angiogenesis assay
;
cell membrane
;
cell transformation
;
cholesterol transport
;
colorectal cancer
;
downstream processing
;
endocytosis
;
epithelial mesenchymal transition
;
exosome
;
extracellular matrix
;
fibroblast
;
gene mutation
;
gene overexpression
;
genotype phenotype correlation
;
glioblastoma
;
human
;
immune response
;
intrinsic activity
;
liver cell carcinoma
;
mass spectrometry
;
metastasis
;
nonhuman
;
overall survival
;
prostate cancer
;
protein expression
;
protein phosphorylation
;
review
;
signal transduction
;
tumor suppressor gene
;
gene expression regulation
;
genetics
;
metabolism
;
metastasis
;
pathology