Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab
Journal
Pediatric Reports
ISSN
2036-7503
Date Issued
2020
Author(s)
Carmen Niño-Taravilla
Yazmín P. Espinosa-Vielma
Lorena I. Tapia
Paula Ortiz-Fritz
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal involvement characterized by inflammation of the wall of the bowel and pancreatitis. After treatment with Tocilizumab and corticoid therapy, he presented clinical improvement and normalization of inflammatory markers. PIMS-TS is a new disease developed in a small percentage of patients, so a high degree of suspicion is necessary to establish the diagnosis. Supportive care is of paramount importance. The use of Tocilizumab to control the inflammatory response is likely to be beneficial, but the best immunotherapeutic agent has not yet been established. Randomized clinical studies should be run to determine the best treatment.</jats:p>
Subjects
mis-c
;
pims-ts
;
sars-cov-2
;
tocilizumab
;
cefotaxime
;
creatine kinase
;
creatinine
;
enoxaparin
;
ferritin
;
lactic acid
;
methylprednisolone
;
pancreas enzyme
;
prednisone
;
sodium chloride
;
tocilizumab
;
troponin t
;
vasoactive agent
;
abdominal pain
;
acute kidney failure
;
antibiotic therapy
;
article
;
cardiogenic shock
;
case report
;
child
;
clinical article
;
colitis
;
corticosteroid therapy
;
diarrhea
;
echography
;
fever
;
fluid resuscitation
;
follow up
;
human
;
hypoalbuminemia
;
hyponatremia
;
hypotension
;
invasive ventilation
;
left ventricular systolic dysfunction
;
male
;
metabolic acidosis
;
multiple organ failure
;
myocarditis
;
nasopharyngeal swab
;
pancreatitis
;
pediatric intensive care unit
;
pediatric multisystem inflammatory syndrome
;
pneumonia
;
polymerase chain reaction
;
school child
;
severe acute respiratory syndrome coronavirus 2
;
single drug dose
;
tachycardia
;
thrombosis
;
thrombosis prevention
;
vomiting