Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior

Journal
The Journal of Neuroscience
ISSN
0270-6474
1529-2401
Date Issued
2019
Author(s)
Avanti Gokhale
Cortnie Hartwig
Amanda A. H. Freeman
Julia L. Bassell
Stephanie A. Zlatic
Christie Sapp Savas
Trishna Vadlamudi
Farida Abudulai
Tyler T. Pham
Amanda Crocker
Erica Werner
Zhexing Wen
Joseph A. Gogos
Steven M. Claypool
Jennifer K. Forsyth
Carrie E. Bearden
Jill Glausier
David A. Lewis
Nicholas T. Seyfried
Jennifer Q. Kwong
Victor Faundez
Type
Resource Types::text::journal::journal article
Scopus ID
2-s2.0-85065511821
WoS ID
WOS:000466352100014
DOI
URL
URL Institutional Repository
Cite this document
Gokhale, A., Hartwig, C., Freeman, A. A. H., Bassell, J. L., Zlatic, S. A., Sapp Savas, C., Vadlamudi, T., Abudulai, F., Pham, T. T., Crocker, A., Werner, E., Wen, Z., Repetto, G. M., Gogos, J. A., Claypool, S. M., Forsyth, J. K., Bearden, C. E., Glausier, J., Lewis, D. A., … Faundez, V. (2019). Systems analysis of the 22q11. 2 microdeletion syndrome converges on a mitochondrial interactome necessary for synapse function and behavior. The Journal of Neuroscience, 1983-18. https://doi.org/10.1523/JNEUROSCI.1983-18.2019
Project(s)
Subjects
22q11.2 microdeletion

; 

mitochondria

; 

schizophrenia

; 

slc25a1

; 

slc25a4

; 

synapse

; 

22q11 deletion syndrome

; 

adenine nucleotide translocator 1

; 

animals

; 

behavior, animal

; 

brain

; 

cell line

; 

chromosome deletion

; 

chromosomes, human, pair 22

; 

drosophila

; 

female

; 

fibroblasts

; 

humans

; 

male

; 

mitochondria

; 

mitochondrial proteins

; 

neurons

; 

organic anion transporters

; 

proteome

; 

schizophrenia

; 

synapses

; 

proteome

; 

adenine nucleotide translocase

; 

mitochondrial protein

; 

organic anion transporter

; 

proteome

; 

slc25a1 protein, human

; 

slc25a4 protein, human

; 

animal husbandry

; 

animal tissue

; 

article

; 

chromosome analysis

; 

chromosome deletion 22q11

; 

controlled study

; 

female

; 

genotype

; 

human

; 

human cell

; 

immunoblotting

; 

immunoprecipitation

; 

immunoreactivity

; 

kolmogorov smirnov test

; 

male

; 

mass spectrometry

; 

mitochondrial membrane

; 

morphology

; 

mouse

; 

nerve cell plasticity

; 

neuromuscular function

; 

neurotransmission

; 

nonhuman

; 

phenotype

; 

priority journal

; 

protein analysis

; 

protein depletion

; 

protein function

; 

proteomics

; 

reproducibility

; 

schizophrenia

; 

synapse

; 

synaptic transmission

; 

animal

; 

animal behavior

; 

brain

; 

cell line

; 

chromosome 22

; 

chromosome deletion

; 

chromosome deletion 22q11

; 

drosophila

; 

fibroblast

; 

metabolism

; 

mitochondrion

; 

nerve cell

; 

schizophrenia