YUBERO GONCALVEZ, MARIA JOAO

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End Stage Renal Disease in a Child with Epidermolysis Bullosa
(2016)
CARLOS FELIPE GONZALO CAVAGNARO SANTA MARIA
;
María Joao Yubero
;
Marcela Valenzuela
;
Francis Palisson
22
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Cells from discarded dressings differentiate chronic from acute wounds in patients with Epidermolysis Bullosa
(2020)
FUENTES BUSTOS, MARIA IGNACIA
;
Christina Guttmann-Gruber
;
Birgit Tockner
;
Anja Diem
;
Alfred Klausegger
<jats:title>Abstract</jats:title><jats:p>Impaired wound healing complicates a wide range of diseases and represents a major cost to healthcare systems. Here we describe the use of discarded wound dressings as a novel, cost effective, accessible, and non-invasive method of isolating viable human cells present at the site of skin wounds. By analyzing 133 discarded wound dressings from 51 patients with the inherited skin-blistering disease epidermolysis bullosa (EB), we show that large numbers of cells, often in excess of 100 million per day, continually infiltrate wound dressings. We show, that the method is able to differentiate chronic from acute wounds, identifying significant increases in granulocytes in chronic wounds, and we show that patients with the junctional form of EB have significantly more cells infiltrating their wounds compared with patients with recessive dystrophic EB. Finally, we identify subsets of granulocytes and T lymphocytes present in all wounds paving the way for single cell profiling of innate and adaptive immune cells with relevance to wound pathologies. In summary, our study delineates findings in EB that have potential relevance for all chronic wounds, and presents a method of cellular isolation that has wide reaching clinical application.</jats:p>
22Scopus© Citations 19
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Patients suffering from dystrophic epidermolysis bullosa are prone to developing autoantibodies against skin proteins: A longitudinal confirmational study
(2024)
J. Bremer
;
H. H. Pas
;
G. F. H. Diercks
;
H. J. Meijer
;
S. M. van der Molen
<jats:title>Abstract</jats:title><jats:p>Epidermolysis bullosa (EB) is a heritable skin blistering disease caused by variants in genes coding for proteins that secure cell–cell adhesion and attachment of the epidermis to the dermis. Interestingly, several proteins involved in inherited EB are also associated with autoimmune blistering diseases (AIBD). In this study, we present a long‐term follow‐up of 15 patients suffering from recessive dystrophic or junctional EB. From these patients, 62 sera were analysed for the presence of autoantibodies associated with AIBD. We show that patients suffering from recessive dystrophic EB (RDEB) are more susceptible to developing autoantibodies against skin proteins than patients suffering from junctional EB (70% vs. 20%, respectively). Interestingly, no correlation with age was observed. Most patients showed reactivity to Type XVII collagen/linear IgA bullous dermatosis autoantigen (<jats:italic>n</jats:italic> = 5; 33%), followed by BP230 (<jats:italic>n</jats:italic> = 4; 27%), Type VII collagen (<jats:italic>n</jats:italic> = 4; 27%) and laminin‐332 (<jats:italic>n</jats:italic> = 1; 7%). The pathogenicity of these autoantibodies remains a subject for future experiments.</jats:p>
Scopus© Citations 3 1
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IMMUNE CELL PROFILING OF WOUNDS FROM EPIDERMOLYSIS BULLOSA PATIENTS
(2020)
YUBERO GONCALVEZ, MARIA JOAO
;
FUENTES BUSTOS, MARIA IGNACIA
;
PALISSON ETCHARREN, FRANCIS
;
REBOLLEDO JARAMILLO, BORIS EDUARDO
;
Guttmann-Gruber, Christina
1
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Novel and recurrent COL7A1 mutations in Chilean patients with dystrophic epidermolysis bullosa
(2012)
Fernando A. Rodríguez
;
María José Gana
;
YUBERO GONCALVEZ, MARIA JOAO
;
Gisela Zillmann
;
Susanne M. Krämer
Scopus© Citations 14 1
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Longitudinal study of wound healing status and bacterial colonisation of
<i>Staphylococcus aureus</i>
and
<i>Corynebacterium diphtheriae</i>
in epidermolysis bullosa patients
(2022)
FUENTES BUSTOS, MARIA IGNACIA
;
YUBERO GONCALVEZ, MARIA JOAO
;
Pilar Morandé
;
Carmen Varela
;
Karen Oróstica
Scopus© Citations 11 2
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Outcomes and Predictors for Re-stenosis of Esophageal Stricture in Epidermolysis Bullosa: A Multicenter Cohort Study
(2020)
Elena Pope
;
Mark Mansour
;
Maria Berseneva
;
Carmen Liy-Wong
;
Julio Salas
16Scopus© Citations 14
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Epidemiology of epidermolysis bullosa in Chile
(2024)
PALISSON ETCHARREN, FRANCIS
;
YUBERO GONCALVEZ, MARIA JOAO
;
Cristóbal Lecaros
;
Susanne Krämer
;
Constanza Fuentes
<jats:p>In this manuscript we are presenting the first National Epidermolysis Bullosa Epidemiology study done in South America. Our manuscript describes not only population-level estimates, such as incidence, prevalence and mortality of EB, but also genetic data that are unique to this underrepresented population. We report new data about this rare disease showing comparable life expectancy to wealthier nations, demonstrating the value of specialized EB care centres.</jats:p>
Scopus© Citations 3 13
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Absence of tongue papillae as a clinical criterion for the diagnosis of generalized recessive dystrophic epidermolysis bullosa types
(2020)
Susanne Krämer
;
FUENTES BUSTOS, MARIA IGNACIA
;
YUBERO GONCALVEZ, MARIA JOAO
;
Carolina Encina
;
José Farfán
1Scopus© Citations 9 2
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Evaluation of three laboratory methods diagnostic sensitivity in influenza A infection: RIDT, DFA and DFA with cytocentrifugation versus RT-PCR
(2014)
Jan Wilhelm
;
YUBERO GONCALVEZ, MARIA JOAO
;
Constanza Fuentes
;
Paulina Ríos
;
Oscar Leyton
12Scopus© Citations 2

YUBERO GONCALVEZ, MARIA JOAO

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