MUNITA SEPULVEDA, JOSE MANUEL

Preferred name

Main Affiliation

Facultad de Medicina Clínica Alemana Universidad del Desarrollo

josemunita@udd.cl

ORCID

0000-0002-7870-1056

Scopus Author ID

24825037700

Goggle Scholar

https://scholar.google.com/citations?user=y3s1KhIAAAAJ&hl=es&oi=ao

Now showing 1 - 10 of 139

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Dataset - Geographic divergence of methicillin-resistant Staphylococcus aureus ST5-SCCmecI in the aftermath of a major earthquake and tsunami: impact of a plasmid harboring heavy metal resistance genes
(United States National Library of Medicine, 2025)
MARTINEZ SOLIS, JOSE RODRIGO WALDEMAR
;
DIAZ ORTIZ, SANDRA LORENA
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QUESILLE VILLALOBOS, ANA MARIA
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ROBERTO ANDRES RIQUELME NEIRA
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RIVAS JIMENEZ, LINA MARIA
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<i>In Vivo</i> Resistance to Ceftolozane/Tazobactam in <i>Pseudomonas aeruginosa</i> Arising by AmpC- and Non-AmpC-Mediated Pathways
(2018)
Erik Skoglund
;
Henrietta Abodakpi
;
Rafael Rios
;
Lorena Diaz
;
Elsa De La Cadena
<jats:p>Two pairs of ceftolozane/tazobactam susceptible/resistant <jats:italic>P. aeruginosa</jats:italic> were isolated from 2 patients after exposure to <jats:italic>β</jats:italic>-lactams. The genetic basis of ceftolozane/tazobactam resistance was evaluated, and <jats:italic>β</jats:italic>-lactam-resistant mechanisms were assessed by phenotypic assays. Whole genome sequencing identified mutations in AmpC including the mutation (V213A) and a deletion of 7 amino acids (P210–G216) in the Ω-loop. Phenotypic assays showed that ceftolozane/tazobactam resistance in the strain with AmpC<jats:sub>V213A</jats:sub> variant was associated with increased <jats:italic>β</jats:italic>-lactamase hydrolysis activity. On the other hand, the deletion of 7 amino acids in the Ω-loop of AmpC did not display enhanced <jats:italic>β</jats:italic>-lactamase activity. Resistance to ceftolozane/tazobactam in <jats:italic>P. aeruginosa</jats:italic> is associated with changes in AmpC; however, the apparent loss of <jats:italic>β</jats:italic>-lactamase activity in AmpC∆7 suggests that non-AmpC mechanisms could play an important role in resistance to <jats:italic>β</jats:italic>-lactam/<jats:italic>β</jats:italic>-lactamase inhibitor combinations.</jats:p>
4
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Dataset - Molecular mechanisms leading to ceftolozane/tazobactam resistance in clinical isolates of Pseudomonas aeruginosa from five Latin American countries
(National Library of Medicine, 2022)
MUNITA SEPULVEDA, JOSE MANUEL
;
JOSE RODRIGO WALDEMAR MARTINEZ SOLIS
9
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Cost-effectiveness of screening, decolonisation and isolation strategies for carbapenem-resistant Enterobacterales and methicillin-resistant Staphylococcus aureus infections in hospitals: a sex-stratified mathematical modelling study
(Elsevier BV, 2025-03)
Kasim Allel
;
Patricia Garcia
;
Anne Peters
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MUNITA SEPULVEDA, JOSE MANUEL
;
Eduardo A. Undurraga
2
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Dataset - Dynamics of the MRSA Population in a Chilean Hospital: a Phylogenomic Analysis (2000-2016)
(2023)
MARTINEZ SOLIS, JOSE RODRIGO WALDEMAR
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SPENCER SANDINO, MARÍA DE LOS ÁNGELES
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RIVAS JIMENEZ, LINA MARIA
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DIAZ ORTIZ, SANDRA
;
QUESILLE VILLALOBOS, ANA MARIA
5
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Dataset - Multispecies emergence of dual blaKPC/NDM carbapenemase-producing Enterobacterales recovered from invasive infections in Chile
(NIH, 2025)
QUESILLE VILLALOBOS, ANA MARIA
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SOLAR, CAMILA
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MARTINEZ SOLIS, JOSE RODRIGO WALDEMAR
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RIVAS JIMENEZ, LINA MARIA
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QUIROZ PALMA, VALERIA CONSTANZA MARIA
11
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DO INTERNATIONAL MIGRANTS FACE HIGHER BACTERIAL DRUG RESISTANCE COMPARED TO NATIVES? A SYSTEMATIC REVIEW
(2019)
CABIESES VALDES, BALTICA BEATRIZ
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MUNITA SEPULVEDA, JOSE MANUEL
;
Anne Peters
;
Acuna, M. P
;
Norman Uphoff
7
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Dataset - Cost-effectiveness of screening, decolonisation and isolation strategies for carbapenem-resistant Enterobacterales and methicillin-resistant Staphylococcus aureus infections in hospitals: a sex-stratified mathematical modelling study
(GITHub, 2025)
PETERS, ANNE SOPHIE
;
MUNITA SEPULVEDA, JOSE MANUEL
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Dataset - NCBI
(National Library of Medicine, 2022)
MUNITA SEPULVEDA, JOSE MANUEL
;
ALCALDE RICO, MANUEL
;
JOSE RODRIGO WALDEMAR MARTINEZ SOLIS
15
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Contemporary Clinical and Molecular Epidemiology of Vancomycin-Resistant Enterococcal Bacteremia: A Prospective Multicenter Cohort Study (VENOUS I)
(2021)
German A Contreras
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MUNITA SEPULVEDA, JOSE MANUEL
;
Shelby Simar
;
Courtney Luterbach
;
An Q Dinh
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Vancomycin-resistant enterococci (VRE) are major therapeutic challenges. Prospective contemporary data characterizing the clinical and molecular epidemiology of VRE bloodstream infections (BSIs) are lacking.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>The Vancomycin-Resistant Enterococcal BSI Outcomes Study (VENOUS I) is a prospective observational cohort of adult patients with enterococcal BSI in 11 US hospitals. We included patients with Enterococcus faecalis or Enterococcus faecium BSI with ≥1 follow-up blood culture(s) within 7 days and availability of isolate(s) for further characterization. The primary study outcome was in-hospital mortality. Secondary outcomes were mortality at days 4, 7, 10, 12, and 15 after index blood culture. A desirability of outcome ranking was constructed to assess the association of vancomycin resistance with outcomes. All index isolates were subjected to whole genome sequencing.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Forty-two of 232 (18%) patients died in hospital and 39 (17%) exhibited microbiological failure (lack of clearance in the first 4 days). Neutropenia (hazard ratio [HR], 3.13), microbiological failure (HR, 2.4), VRE BSI (HR, 2.13), use of urinary catheter (HR, 1.85), and Pitt BSI score ≥2 (HR, 1.83) were significant predictors of in-hospital mortality. Microbiological failure was the strongest predictor of in-hospital mortality in patients with E faecium bacteremia (HR, 5.03). The impact of vancomycin resistance on mortality in our cohort changed throughout the course of hospitalization. Enterococcus faecalis sequence type 6 was a predominant multidrug-resistant lineage, whereas a heterogeneous genomic population of E faecium was identified.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Failure of early eradication of VRE from the bloodstream is a major factor associated with poor outcomes.</jats:p> </jats:sec>
5Scopus© Citations 42

MUNITA SEPULVEDA, JOSE MANUEL

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