Transmission of gram-negative antibiotic-resistant bacteria following differing exposure to antibiotic-resistance reservoirs in a rural community: a modelling study for bloodstream infections
Journal
Scientific Reports
ISSN
2045-2322
Date Issued
2022
Author(s)
Kasim Allel
Lara Goscé
Daniel Toro
Catterina Ferreccio
Eduardo A. Undurraga
Jasmina Panovska-Griffiths
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:title>Abstract</jats:title><jats:p>Exposure to community reservoirs of gram-negative antibiotic-resistant bacteria (GN-ARB) genes poses substantial health risks to individuals, complicating potential infections. Transmission networks and population dynamics remain unclear, particularly in resource-poor communities. We use a dynamic compartment model to assess GN-ARB transmission quantitatively, including the susceptible, colonised, infected, and removed populations at the community-hospital interface. We used two side streams to distinguish between individuals at high- and low-risk exposure to community ARB reservoirs. The model was calibrated using data from a cross-sectional cohort study (N = 357) in Chile and supplemented by existing literature. Most individuals acquired ARB from the community reservoirs (98%) rather than the hospital. High exposure to GN-ARB reservoirs was associated with 17% and 16% greater prevalence for GN-ARB carriage in the hospital and community settings, respectively. The higher exposure has led to 16% more infections and attributed mortality. Our results highlight the need for early-stage identification and testing capability of bloodstream infections caused by GN-ARB through a faster response at the community level, where most GN-ARB are likely to be acquired. Increasing treatment rates for individuals colonised or infected by GN-ARB and controlling the exposure to antibiotic consumption and GN-ARB reservoirs, is crucial to curve GN-ABR transmission.</jats:p>
Cite this document
Allel, K., Goscé, L., Araos, R., Toro, D., Ferreccio, C., Munita, J. M., Undurraga, E. A., & Panovska-Griffiths, J. (2022). Transmission of gram-negative antibiotic-resistant bacteria following differing exposure to antibiotic-resistance reservoirs in a rural community: A modelling study for bloodstream infections. Scientific Reports, 12(1), 13488. https://doi.org/10.1038/s41598-022-17598-x
Dataset(s)
Dataset - Transmission of gram-negative antibiotic-resistant bacteria following differing exposure to antibiotic-resistance reservoirs in a rural community: a modelling study for bloodstream infections
Subjects
angiotensin receptor antagonists
;
angiotensin-converting enzyme inhibitors
;
anti-bacterial agents
;
cross-sectional studies
;
drug resistance, bacterial
;
gram-negative bacteria
;
humans
;
rural population
;
sepsis
;
angiotensin receptor antagonist
;
antiinfective agent
;
dipeptidyl carboxypeptidase inhibitor
;
antibiotic resistance
;
cross-sectional study
;
gram negative bacterium
;
human
;
rural population
;
sepsis