Perspective on Clinically-Relevant Antimicrobial Resistant Enterobacterales in Food: Closing the Gaps Using Genomics
Journal
Frontiers in Sustainable Food Systems
ISSN
2571-581X
Date Issued
2021
Author(s)
Constanza Díaz-Gavidia
Francisca P. Álvarez
Sandra Cortés
Andrea I. Moreno-Switt
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Antimicrobial resistance is one of the most important public health concerns—it causes 700,000 deaths annually according to the World Health Organization (WHO). Enterobacterales such as <jats:italic>E. coli</jats:italic> and <jats:italic>Klebsiella pneumoniae</jats:italic>, have become resistant to many relevant antimicrobials including carbapenems and extended spectrum cephalosporins. These clinically relevant resistant Enterobacterales (CRRE) members are now globally distributed in the environment including different food types (meats, produce, dairy). Unlike known foodborne pathogens, CRRE are not usually part of most food surveillance systems. However, numerous reports of CRRE highlight the importance of these bacteria in food and have been shown to contribute to the overall crisis of antimicrobial resistance. This is especially important in the context of carriage of these pathogens by immuno-compromised individuals. CRRE infections upon consumption of contaminated food could colonize the human gastrointestinal tract and eventually be a source of systemic infections such as urinary tract infections or septicemia. While different aspects need to be considered to elucidate this, whole genome sequencing along with metadata could be used to understand genomic relationships of CRRE obtained from foods and humans, including isolates from clinical infections. Once robust scientific data is available on the role of CRRE in food, countries could move forward to better survey and control CRRE in food.</jats:p>
Cite this document
Díaz-Gavidia, C., Álvarez, F. P., Munita, J. M., Cortés, S., & Moreno-Switt, A. I. (2021). Perspective on clinically-relevant antimicrobial resistant enterobacterales in food: Closing the gaps using genomics. Frontiers in Sustainable Food Systems, 5, 667504. https://doi.org/10.3389/fsufs.2021.667504
Subjects
antimicrobial resistance
;
genomics
;
clinically relevant bacteria
;
escherichia coli
;
klebsiella pneumoniae
;
food safety
;
resistant bacteria in food