Sex differences in treatment, radiological features and outcome after intracerebral haemorrhage: Pooled analysis of Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage trials 1 and 2
Journal
European Stroke Journal
ISSN
2396-9873
2396-9881
Date Issued
2020
Author(s)
Else Charlotte Sandset
Xia Wang
Cheryl Carcel
Shoichiro Sato
Candice Delcourt
Hisatomi Arima
Christian Stapf
Thompson Robinson
John Chalmers
Mark Woodward
Craig S Anderson
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:sec><jats:title>Introduction</jats:title><jats:p> Reports vary on how sex influences the management and outcome from acute intracerebral haemorrhage. We aimed to quantify sex disparities in clinical characteristics, management, including response to blood pressure lowering treatment, and outcomes in patients with acute intracerebral haemorrhage, through interrogation of two large clinical trial databases. </jats:p></jats:sec><jats:sec><jats:title>Patients and Methods</jats:title><jats:p> Post-hoc pooled analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage trials 1 and 2, where patients with a hypertensive response (systolic, 150–220 mmHg) after spontaneous intracerebral haemorrhage (<6 h) were randomised to intensive (target <140 mmHg <1 h) or guideline-recommended (<180 mmHg) blood pressure lowering treatment. The interaction of sex on early haematoma growth (24 h), death or major disability (modified Rankin scale scores 3–6 at 90 days), and effect of randomised treatment were determined in multivariable logistic regression models adjusted for baseline confounding variables. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> In 3233 participants, 1191 (37%) were women who were significantly older, had higher baseline National Institutes of Health Stroke Scale scores and smaller haematoma volumes compared to men. Men had higher three-month mortality (odds ratio 1.48, 95% confidence interval 1.10–2.00); however, there was no difference between women and men in the combined endpoint of death or major disability. There were no significant sex differences on mean haematoma growth or effect of randomised blood pressure lowering treatment. </jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p> Men included in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage trials had more comorbidities, larger baseline haematoma volumes and higher mortality after adjustment for age, as compared with women. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Men included in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage trials had a greater odds of dying after intracerebral haemorrhage than women, which could not be readily explained by differing casemix or patterns of blood pressure management. </jats:p></jats:sec><jats:sec><jats:title>Clinical trial registration</jats:title><jats:p> The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage trials studies are registered with ClinicalTrials.gov (NCT00226096 and NCT00716079). </jats:p></jats:sec>
Cite this document
Sandset, E. C., Wang, X., Carcel, C., Sato, S., Delcourt, C., Arima, H., Stapf, C., Robinson, T., Lavados, P., Chalmers, J., Woodward, M., & Anderson, C. S. (2020). Sex differences in treatment, radiological features and outcome after intracerebral haemorrhage: Pooled analysis of Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage trials 1 and 2. European Stroke Journal, 5(4), 345-350. https://doi.org/10.1177/2396987320957513
Subjects
blood pressure
;
haematoma growth
;
intracerebral haemorrhage
;
perihaematomal oedema
;
sex differences
;
anticoagulant agent
;
antilipemic agent
;
hemostatic agent
;
mannitol
;
adult
;
antihypertensive therapy
;
article
;
bleeding
;
blood pressure
;
brain hemorrhage
;
brain ischemia
;
clinical outcome
;
computer assisted tomography
;
diabetes mellitus
;
disability
;
edema
;
female
;
glasgow coma scale
;
haematoma growth
;
haematoma location
;
haematoma volume
;
hematoma
;
human
;
hyperglycemia
;
hypertension
;
intensive care unit
;
intraventricular extension
;
intubation
;
major clinical study
;
male
;
middle aged
;
mortality
;
national institutes of health stroke scale
;
neurologic examination
;
outcome assessment
;
perihaematomal growth
;
phase 1 clinical trial (topic)
;
phase 2 clinical trial (topic)
;
priority journal
;
prognosis
;
radiography
;
randomized controlled trial (topic)
;
rankin scale
;
sex difference
;
systolic blood pressure
;
venous thromboembolism