Ceftaroline-Resistant, DaptomycinTolerant, and Heterogeneous Vancomycin-Intermediate MethicillinResistant Staphylococcus aureus Causing Infective Endocarditis
Journal
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804
1098-6596
Date Issued
2017
Author(s)
Masayuki Nigo
Lorena Diaz
Lina P. Carvajal
Truc T. Tran
Rafael Rios
Diana Panesso
Juan D. Garavito
William R. Miller
Audrey Wanger
George Weinstock
Cesar A. Arias
Henry F. Chambers
Type
Resource Types::text::journal::journal article
DOI
URL
Abstract
<jats:title>ABSTRACT</jats:title> <jats:p> We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant <jats:named-content content-type="genus-species">S. aureus</jats:named-content> (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype. </jats:p>