Acquisition of resistance to ceftazidime-avibactam during infection treatment in Pseudomonas aeruginosa through D179Y mutation in one of two blaKPC-2 gene copies without losing carbapenem resistance

Journal
Frontiers in Cellular and Infection Microbiology
ISSN
22352988
Date Issued
2022-09
Author(s)
García, Patricia
Brito, Bárbara
Martínez, José R.W.
Olivares-Pacheco, Jorge
Quiroz, Valeria
Wozniak, Aniela
Type
Resource Types::text::journal::journal article
Scopus ID
2-s2.0-85138170966
WoS ID
WOS:000872922700001
DOI
URL
URL Institutional Repository
Cite this document
García, P., Brito, B., Alcalde-Rico, M., Munita, J. M., Martínez, J. R. W., Olivares-Pacheco, J., Quiroz, V., & Wozniak, A. (2022). Acquisition of resistance to ceftazidime-avibactam during infection treatment in Pseudomonas aeruginosa through D179Y mutation in one of two blaKPC-2 gene copies without losing carbapenem resistance. Frontiers in Cellular and Infection Microbiology, 12, 981792. https://doi.org/10.3389/fcimb.2022.981792
Project(s)
Dataset(s)
Subjects
bla<sub>kpc-2</sub> gene

; 

ceftazidime/avibactam resistance

; 

d179y substitution

; 

pseudomonas aeruginosa

; 

tn4401b transposon

; 

anti-bacterial agents

; 

azabicyclo compounds

; 

beta-lactamases

; 

carbapenems

; 

ceftazidime

; 

drug combinations

; 

humans

; 

microbial sensitivity tests

; 

mutation

; 

porins

; 

pseudomonas aeruginosa

; 

avibactam plus ceftazidime

; 

beta lactamase ampc

; 

carbapenemase

; 

colistin

; 

outer membrane protein

; 

antiinfective agent

; 

avibactam, ceftazidime drug combination

; 

azabicyclo derivative

; 

beta lactamase

; 

carbapenem derivative

; 

ceftazidime

; 

porin

; 

amino acid substitution

; 

antibiotic resistance

; 

antibiotic sensitivity

; 

article

; 

bacterial gene

; 

bacterium isolate

; 

blakpc-2 gene

; 

broth dilution

; 

carbapenem resistance

; 

controlled study

; 

ctpa gene

; 

dnak gene

; 

esrc gene

; 

ftsi gene

; 

gene

; 

gene dosage

; 

gene mutation

; 

immunoaffinity chromatography

; 

mexab-oprm gene

; 

mexd gene

; 

mexr gene

; 

mext gene

; 

mexz gene

; 

minimum inhibitory concentration

; 

nalc gene

; 

nald gene

; 

nfxb gene

; 

nonhuman

; 

oprd gene

; 

polyacrylamide gel electrophoresis

; 

polymerase chain reaction

; 

pseudomonas infection

; 

tn4401b transposon

; 

transposon

; 

whole genome sequencing

; 

drug combination

; 

genetics

; 

human

; 

metabolism

; 

microbial sensitivity test

; 

mutation

; 

pseudomonas aeruginosa