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Project Title
THE EFFECTS OF COLCHICINE ON CORONARY MICROVASCULAR REPERFUSION AND RESIDUAL INFLAMMATORY RISK IN PATIENTS WITH ACUTE CORONARY SYNDROME.
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Internal ID
1210655
Principal Investigator
Gonzalo Javier Martínez Rodríguez
Start Date
2020
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Publication

Cardiovascular events risk in patients with systemic autoimmune diseases: a prognostic systematic review and meta-analysis

2023 , Claudia Asenjo-Lobos , Leticia González , Juan Francisco Bulnes , Marta Roque , MUÑOZ VENTURELLI, PAULA ANDREA , Gonzalo Martínez Rodríguez

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The Role of Colchicine in Atherosclerosis: From Bench to Bedside

2022 , Leticia González , Juan Francisco Bulnes , María Paz Orellana , MUÑOZ VENTURELLI, PAULA ANDREA , Gonzalo Martínez Rodriguez

Inflammation is a key feature of atherosclerosis. The inflammatory process is involved in all stages of disease progression, from the early formation of plaque to its instability and disruption, leading to clinical events. This strongly suggests that the use of anti-inflammatory agents might improve both atherosclerosis progression and cardiovascular outcomes. Colchicine, an alkaloid derived from the flower Colchicum autumnale, has been used for years in the treatment of inflammatory pathologies, including Gout, Mediterranean Fever, and Pericarditis. Colchicine is known to act over microtubules, inducing depolymerization, and over the NLRP3 inflammasome, which might explain its known anti-inflammatory properties. Recent evidence has shown the therapeutic potential of colchicine in the management of atherosclerosis and its complications, with limited adverse effects. In this review, we summarize the current knowledge regarding colchicine mechanisms of action and pharmacokinetics, as well as the available evidence on the use of colchicine for the treatment of coronary artery disease, covering basic, translational, and clinical studies.

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