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Project Title
Mecanismo Inmunologicos Protectores y Biomarcadores de Respuesta Inmmune en Covid 19 Identificación de Dianas Terapeuticas Para la Recomendación de Terapias Inmunomoduladoras de Uso Precoz
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Internal ID
COVID0999
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Start Date
2020

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Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

2022 , Keith Sacco , Riccardo Castagnoli , Svetlana Vakkilainen , Can Liu , Ottavia M. Delmonte , Cihan Oguz , Ian M. Kaplan , Sara Alehashemi , Peter D. Burbelo , Farzana Bhuyan , Adriana A. de Jesus , Kerry Dobbs , Lindsey B. Rosen , Aristine Cheng , Elana Shaw , Mikko S. Vakkilainen , Francesca Pala , Justin Lack , Yu Zhang , Danielle L. Fink , Vasileios Oikonomou , Andrew L. Snow , Clifton L. Dalgard , Jinguo Chen , Brian A. Sellers , Gina A. Montealegre Sanchez , Karyl Barron , REY JURADO, EMMA , VIAL COX, MARIA CECILIA , POLI HARLOWE, MARIA CECILIA BERTA , Amelia Licari , Daniela Montagna , Gian Luigi Marseglia , Francesco Licciardi , Ugo Ramenghi , Valentina Discepolo , Andrea Lo Vecchio , Alfredo Guarino , Eli M. Eisenstein , Luisa Imberti , Alessandra Sottini , Andrea Biondi , Sayonara Mató , Dana Gerstbacher , Meng Truong , Michael A. Stack , Mary Magliocco , Marita Bosticardo , Tomoki Kawai , Jeffrey J. Danielson , Tyler Hulett , Manor Askenazi , Shaohui Hu , Jason Barnett , Xi Cheng , Krishnaveni Kaladi , Vasudev Kuram , Joseph Mackey , Neha M. Bansal , Andrew J. Martins , Boaz Palterer , Helen Matthews , Uma Mudunuri , Marshall Nambiar , Andrew J. Oler , Andre Rastegar , Smilee Samuel , Conrad Shyu , Varsha Waingankar , Sarah Weber , Sandhya Xirasagar , Yazmin Espinosa , Camila Astudillo , Cecilia Piñera , Ricardo González , Maria De Filippo , Martina Votto , Lorenza Montagna , Jeffrey I. Cohen , Helen C. Su , Douglas B. Kuhns , Michail S. Lionakis , Thomas M. Snyder , Steven M. Holland , Raphaela Goldbach-Mansky , John S. Tsang , Luigi D. Notarangelo

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Publication

Autoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-C

2022 , Peter D. Burbelo , Riccardo Castagnoli , Chisato Shimizu , Ottavia M. Delmonte , Kerry Dobbs , Valentina Discepolo , Andrea Lo Vecchio , Alfredo Guarino , Francesco Licciardi , Ugo Ramenghi , REY JURADO, EMMA , VIAL COX, MARIA CECILIA , Gian Luigi Marseglia , Amelia Licari , Daniela Montagna , Camillo Rossi , Gina A. Montealegre Sanchez , Karyl Barron , Blake M. Warner , John A. Chiorini , Yazmin Espinosa , Loreani Noguera , Lesia Dropulic , Meng Truong , Dana Gerstbacher , Sayonara Mató , John Kanegaye , Adriana H. Tremoulet , Eli M. Eisenstein , Helen C. Su , Luisa Imberti , POLI HARLOWE, MARIA CECILIA BERTA , Jane C. Burns , Luigi D. Notarangelo , Jeffrey I. Cohen

The antibody profile against autoantigens previously associated with autoimmune diseases and other human proteins in patients with COVID-19 or multisystem inflammatory syndrome in children (MIS-C) remains poorly defined. Here we show that 30% of adults with COVID-19 had autoantibodies against the lung antigen KCNRG, and 34% had antibodies to the SLE-associated Smith-D3 protein. Children with COVID-19 rarely had autoantibodies; one of 59 children had GAD65 autoantibodies associated with acute onset of insulin-dependent diabetes. While autoantibodies associated with SLE/Sjögren’s syndrome (Ro52, Ro60, and La) and/or autoimmune gastritis (gastric ATPase) were detected in 74% (40/54) of MIS-C patients, further analysis of these patients and of children with Kawasaki disease (KD), showed that the administration of intravenous immunoglobulin (IVIG) was largely responsible for detection of these autoantibodies in both groups of patients. Monitoring in vivo decay of the autoantibodies in MIS-C children showed that the IVIG-derived Ro52, Ro60, and La autoantibodies declined to undetectable levels by 45-60 days, but gastric ATPase autoantibodies declined more slowly requiring >100 days until undetectable. Further testing of IgG and/or IgA antibodies against a subset of potential targets identified by published autoantigen array studies of MIS-C failed to detect autoantibodies against most (16/18) of these proteins in patients with MIS-C who had not received IVIG. However, Troponin C2 and KLHL12 autoantibodies were detected in 2 of 20 and 1 of 20 patients with MIS-C, respectively. Overall, these results suggest that IVIG therapy may be a confounding factor in autoantibody measurements in MIS-C and that antibodies against antigens associated with autoimmune diseases or other human proteins are uncommon in MIS-C.

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Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19

2022 , Carmelo Carmona-Rivera , Yu Zhang , Kerry Dobbs , Tovah E. Markowitz , Clifton L. Dalgard , Andrew J. Oler , Dillon R. Claybaugh , Deborah Draper , Meng Truong , Ottavia M. Delmonte , Francesco Licciardi , Ugo Ramenghi , Nicoletta Crescenzio , Luisa Imberti , Alessandra Sottini , Virginia Quaresima , Chiara Fiorini , Valentina Discepolo , Andrea Lo Vecchio , Alfredo Guarino , Luca Pierri , Andrea Catzola , Andrea Biondi , Paolo Bonfanti , POLI HARLOWE, MARIA CECILIA BERTA , Yasmin Espinosa , Camila Astudillo , REY JURADO, EMMA , VIAL COX, MARIA CECILIA , Javiera de la Cruz , Ricardo Gonzalez , Cecilia Pinera , Jacqueline W. Mays , Ashley Ng , Andrew Platt , Beth Drolet , John Moon , Edward W. Cowen , Heather Kenney , Sarah E. Weber , Riccardo Castagnoli , Mary Magliocco , Michael A. Stack , Gina Montealegre , Karyl Barron , Danielle L. Fink , Douglas B. Kuhns , Stephen M. Hewitt , Lisa M. Arkin , Daniel S. Chertow , Helen C. Su , Luigi D. Notarangelo , Mariana J. Kaplan

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Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohort

2022 , REY JURADO, EMMA , Yazmin Espinosa , Camila Astudillo , CORTES SALINAS, LINA JIMENA , HORMAZABAL CASTILLO, JUAN PATRICIO , Fernanda Cofré , Cecilia Piñera , Loreani P. Noguera , Ricardo González , Alexander Bataszew , MUÑOZ VENTURELLI, PAULA ANDREA , Dona Benadof , Patricia Álvarez , Valeria Acevedo , VIAL CLARO, PABLO AGUSTIN , VIAL COX, MARIA CECILIA , POLI HARLOWE, MARIA CECILIA BERTA

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