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Project Title
Estudio de seroprevalencia seriada: seguimiento de la inmunidad a la infección por SARS-Cov-2 y monitoreo de cobertura efectiva de vacunación, en dos ciudades chilenas
Partner Organisations
Internal ID
SA21I0009
Principal Investigator
Muriel Millaray Ramirez Santana
Status
VIGENTE
End Date
2023

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Seroprevalence of Natural and Acquired Immunity against the SARS-CoV-2 Virus in a Population Cohort from Two Chilean Cities, 2020–2022

2023 , Loreto Núñez-Franz , Muriel Ramírez-Santana , RUBILAR RAMIREZ, PAOLA , Macarena Said , VIAL COX, MARIA CECILIA , Luis Canales , GONZALEZ WIEDMAIER, CLAUDIA MARTA , APABLAZA SALINAS, MAURICIO IVÁN , Gloria Icaza , HORMAZABAL CASTILLO, JUAN PATRICIO , Rubén Quezada-Gaete , VIAL CLARO, PABLO AGUSTIN , Kathya Olivares , CORTES SALINAS, LINA JIMENA , AGUILERA SANHUEZA, XIMENA PAZ

Background: Chile has achieved the highest coverage for vaccines against the SARS-CoV-2 virus worldwide. Objective: To assess the progression of immunity (natural and acquired by vaccine) in a cohort from two Chilean cities. Methods: Individuals (n = 386) who participated in three phases of population-based serial prevalence studies were included (2020–2021 and 2022). Presence of SARS-CoV-2 antibodies was measured in serum. Data including time of vaccination and type of vaccine received were analysed with descriptive statistics. Results: Seroprevalence was 3.6% in the first round and increased to 96.9% in the second and 98.7% in the third. In the third round, 75% of individuals who had received the basal full scheme were seropositive at 180 days or more since their last dose; 98% of individuals who received one booster dose were seropositive at 180 days or more, and 100% participants who received two boosters were seropositive, regardless of time since their last dose. Participants receiving mRNA vaccines had higher seroprevalence rates over time. Conclusions: The high vaccination coverage in Chile enabled the population to maintain high levels of antibodies. Vaccination boosters are essential to maintain immunity over time, which also depends on the type of vaccine administered.

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Factors influencing neutralizing antibody response to the original SARS-CoV-2 virus and the Omicron variant in a high vaccination coverage country, a population-based study

2023 , HORMAZABAL CASTILLO, JUAN PATRICIO , Loreto Nuñez-Franz , RUBILAR RAMIREZ, PAOLA ANDREA , APABLAZA SALINAS, MAURICIO IVÁN , VIAL COX, MARIA CECILIA , CORTES SALINAS, LINA JIMENA , Macarena Said , Kathya Olivares , VIAL CLARO, PABLO AGUSTIN , Muriel Ramírez-Santana , GONZALEZ WIEDMAIER, CLAUDIA MARTA , Natalia González , AGUILERA SANHUEZA, XIMENA PAZ

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