Project Title
Characterization of the intestinal phageome in individuals colonized and not colonized with antimicrobial-resistant bacteria
Partner Organisations
Internal ID
3201034
Principal Investigator
Start Date
2020

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    Item type:Publication,
    Multispecies emergence of dual blaKPC/NDM carbapenemase-producing Enterobacterales recovered from invasive infections in Chile
    (American Society for Microbiology, 2025-01-31)
    QUESILLE VILLALOBOS, ANA MARIA  
    ;
    Camila Solar
    ;
    Jose R. W. MartĂ­nez
    ;
    RIVAS JIMENEZ, LINA MARIA  
    ;
    Valeria Quiroz
    Carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) represent a significant global threat. The emergence of dual CP-CRE is particularly alarming, as they can potentially compromise the efficacy of newer antibiotics, further decreasing therapeutic alternatives. Herein, we report the emergence of multiple species of CP-CRE recovered from invasive infections in Chile that simultaneously harbor and provide an in-depth genomic characterization of these worrisome pathogens. We collected carbapenem-resistant Enterobacterales (CRE) isolates from invasive infections over a 4-year period, across 11 healthcare centers in Chile. Bacterial species and the presence of carbapenemase genes were confirmed using MALDI-TOF and PCR assays, respectively. Antimicrobial susceptibility testing was conducted through disk diffusion and broth microdilution methods. Dual CP-CRE isolates were subjected to short- and long-read whole genome sequencing to perform a detailed genomic characterization of the isolates and of the mobile genetic elements harboring the enzymes. From a total of 1,335 CRE isolates, we observed an increase in the prevalence of CP-CRE, from 11% in 2019 to 38% in 2022. A total of 11 dual CP-CRE isolates were recovered, all of them harboring
    Scopus© Citations 10  15