CABRERA MORAGA, RAUL ALEJANDRO
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CABRERA MORAGA, RAUL ALEJANDRO
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rcabrera@udd.cl
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Scopus Author ID
35897938700

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The Role of CXCL10 and IL-18 as Markers of Repigmentation Response in Nonsegmental Vitiligo Treated with Narrowband UVB Phototherapy: A Prospective Cohort Study

2021 , HOJMAN CANO, LIA PAULA , Claudio Karsulovic , CABRERA MORAGA, RAUL ALEJANDRO , Fabian Tempio , Claudio Perez , Mercedes López

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Dermoscopy in the diagnosis of tungiasis

2009 , CABRERA MORAGA, RAUL ALEJANDRO , Daza, Francisca

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Non-Canonical WNT/Wnt5a Pathway Activity in Circulating Monocytes of Untreated Psoriatic Patients: An Exploratory Study of Its Association with Inflammatory Cytokines and Cardiovascular Risk Marker-ADAMTS7

2023 , Claudio Karsulovic , Khanty Loyola , CABRERA MORAGA, RAUL ALEJANDRO , Claudio Perez , Lia Hojman

The leading cause of death in psoriasis is cardiovascular disease. The determinants that induce the increase in this risk are not known. The systemic inflammatory process is dependent on lymphocytes and monocytes, as has been proposed. However, adaptation modules such as mTOR have recently been mentioned as having a role. Other factors, such as WNT and its non-canonical WNT5a-inducing pathway, are relevant in inflammation, cell migration, and neoangiogenesis. Thus, we studied circulating monocytes from untreated severe psoriatic patients and characterized inflammatory cytokines, chemokines, mTOR activity, and the cardiovascular risk marker ADAMTS7. Peripheral blood from ten severely psoriatic patients (Psoriasis severity index greater than 10) was extracted and age- and sex-matched with healthy subjects. Surface and intracellular flow cytometry were performed for cytokine, chemokine receptors, and mTOR activity. ADAMTS7 was measured using ELISA. Psoriatic patients had a higher frequency of WNT5a+ cells in monocytes, which also had higher levels of IL-1β, IL-6, CXCR3, CCR2, and phosphorylated S6R protein. We found that M1 monocytes are dominant in the WNT5a+ cell group, and intracellular levels of WNT5a were also augmented. Levels of WNT5a were correlated with ADAMTS7, a blood marker related to the pathogenesis of atheromatosis. WNT5a could be relevant to the cardiovascular risk of psoriatic patients considering its association with higher levels of inflammatory cytokines, chemokine receptors and the pro-atherogenic profile of circulating monocytes.

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Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients

2018 , CABRERA MORAGA, RAUL ALEJANDRO , L Hojman , F Recule , R Sepulveda , I Delgado , DELGADO BECERRA, OROZIMBA IRIS

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Papular‐purpuric exanthem in a COVID‐19 patient: clinical and dermoscopic description

2020 , JORGE FELIPE LARRONDO GALVEZ , CABRERA MORAGA, RAUL ALEJANDRO , M. Gosch , F. Larrondo , AYLWIN RAMIREZ, MABEL CRISTINA , CASTRO MENDEZ, ALEX

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Cromhidrosis ecrina por hiperbilirrubinemia secundaria a terapia antirretroviral

2017 , Jaime Pérez W. , CABRERA MORAGA, RAUL ALEJANDRO , CASTRO MENDEZ, ALEX , Fernando Pérez , Agustina Romanello , Máximo Venegas , Viviana García

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Tinea faciei por Trichophyton violaceum: primer caso alóctono reportado en Chile

2022 , CABRERA MORAGA, RAUL ALEJANDRO , Sofía Guelfand , Macarena Stevenson , Marie-Chantal Caussade , Daniel Velázquez , Eduardo Álvarez

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Dermatoscopy of an Angiomatoid Spitz Nevus

2011 , CABRERA MORAGA, RAUL ALEJANDRO , Francisca Daza , Denis Tom , Victor G Prieto , CASTRO MENDEZ, ALEX

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Tungiasis: eggs seen with dermoscopy

2008 , CABRERA MORAGA, RAUL ALEJANDRO , Daza, Francisca

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Unusual Clinical Presentations of Malignant Melanoma: A Review of Clinical and Histologic Features with Special Emphasis on Dermatoscopic Findings

2018 , CABRERA MORAGA, RAUL ALEJANDRO , Francisca Recule

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