SOTO ICAZA, PATRICIA
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SOTO ICAZA, PATRICIA
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patriciasoto@udd.cl
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56951221700

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Theta and Alpha Oscillation Impairments in Autistic Spectrum Disorder Reflect Working Memory Deficit

2017 , Josefina Larrain-Valenzuela , ZAMORANO M, FRANCISCO JAVIER , SOTO ICAZA, PATRICIA , Ximena Carrasco , Claudia Herrera , Francisca Daiber , Francisco Aboitiz , BILLEKE BOBADILLA, PABLO ERNESTO

A dysfunction in the excitatory–inhibitory (E/I) coordination in neuronal assembly has been proposed as a possible neurobiological mechanism of Autistic Spectrum Disorder (ASD). However, the potential impact of this mechanism in cognitive performance is not fully explored. Since the main consequence of E/I dysfunction is an impairment in oscillatory activity and its underlying cognitive computations, we assessed the electroencephalographic activity of ASD and typically developing (TD) subjects during a working-memory task. We found that ASD subjects committed more errors than TD subjects. Moreover, TD subjects demonstrated a parametric modulation in the power of alpha and theta band while ASD subjects did not demonstrate significant modulations. The preceding leads to significant differences between the groups in both the alpha power placed on the occipital cortex and the theta power placed on the left premotor and the right prefrontal cortex. The impaired theta modulation correlated with autistic symptoms. The results indicated that ASD may present an alteration in the recruitment of the oscillatory activity during working-memory, and this alteration could be related to the physiopathology of the disorder.

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Development of social skills in children: neural and behavioral evidence for the elaboration of cognitive models

2015 , SOTO ICAZA, PATRICIA , Francisco Aboitiz , BILLEKE BOBADILLA, PABLO ERNESTO

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A multimodal interface for speech perception: the role of the left superior temporal sulcus in social cognition and autism

2024 , Leonie Kausel , Maëva Michon , SOTO ICAZA, PATRICIA , Francisco Aboitiz

Abstract Multimodal integration is crucial for human interaction, in particular for social communication, which relies on integrating information from various sensory modalities. Recently a third visual pathway specialized in social perception was proposed, which includes the right superior temporal sulcus (STS) playing a key role in processing socially relevant cues and high-level social perception. Importantly, it has also recently been proposed that the left STS contributes to audiovisual integration of speech processing. In this article, we propose that brain areas along the right STS that support multimodal integration for social perception and cognition can be considered homologs to those in the left, language-dominant hemisphere, sustaining multimodal integration of speech and semantic concepts fundamental for social communication. Emphasizing the significance of the left STS in multimodal integration and associated processes such as multimodal attention to socially relevant stimuli, we underscore its potential relevance in comprehending neurodevelopmental conditions characterized by challenges in social communication such as autism spectrum disorder (ASD). Further research into this left lateral processing stream holds the promise of enhancing our understanding of social communication in both typical development and ASD, which may lead to more effective interventions that could improve the quality of life for individuals with atypical neurodevelopment.

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Beta oscillations precede joint attention and correlate with mentalization in typical development and autism

2019 , SOTO ICAZA, PATRICIA , Lorena Vargas , Francisco Aboitiz , BILLEKE BOBADILLA, PABLO ERNESTO

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Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations

2024 , Leonie Kausel , Alejandra Figueroa-Vargas , José Zamorano-abramson , STECHER GUZMAN, XIMENA PATRICIA , Mauricio Aspé-Sánchez , Claudio Román , Patricio Carvajal-Paredes , Victor Márquez-Rodríguez , Patricio Soto-Fernández , Reinaldo Uribe-San-Martín , Gabriela Valdebenito-Oyarzo , Rodrigo Henríquez-Ch , Carla Manterola , SILVA FUENTE ALBA, CLAUDIO SERGIO , Francisco Aboitiz , María Paz Martínez-Molina , Rafael Polania , Pamela Guevara , MUÑOZ VENTURELLI, PAULA ANDREA , SOTO ICAZA, PATRICIA , BILLEKE BOBADILLA, PABLO ERNESTO

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Differences in cortical processing of facial emotions in broader autism phenotype

2022 , SOTO ICAZA, PATRICIA , Brice Beffara-Bret , Lorena Vargas , Francisco Aboitiz , BILLEKE BOBADILLA, PABLO ERNESTO , Cosimo Urgesi

Autism Spectrum Disorder (ASD) is a heterogeneous condition that affects face perception. Evidence shows that there are differences in face perception associated with the processing of low spatial frequency (LSF) and high spatial frequency (HSF) of visual stimuli between non-symptomatic relatives of individuals with autism (broader autism phenotype, BAP) and typically developing individuals. However, the neural mechanisms involved in these differences are not fully understood. Here we tested whether face-sensitive event related potentials could serve as neuronal markers of differential spatial frequency processing, and whether these potentials could differentiate non-symptomatic parents of children with autism (pASD) from parents of typically developing children (pTD). To this end, we performed electroencephalographic recordings of both groups of parents while they had to recognize emotions of face pictures composed of the same or different emotions (happiness or anger) presented in different spatial frequencies. We found no significant differences in the accuracy between groups but lower amplitude modulation in the Late Positive Potential activity in pASD. Source analysis showed a difference in the right posterior part of the superior temporal region that correlated with ASD symptomatology of the child. These results reveal differences in brain processing of recognition of facial emotion in BAP that could be a precursor of ASD.

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