LAVADOS GERMAIN, PABLO MANUEL
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LAVADOS GERMAIN, PABLO MANUEL
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p.lavados@udd.cl
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57188955599

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2024 2024 2023 2023 2022 2022 2021 2021 2020 2020 2019 2019 2018 2018 2017 2017 2016 2016 2015 2015 0 0 2 2 4 4 6 6 8 8 10 10 12 12 14 14 16 16 18 18
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Abstract P84: Covid-19 and Stroke in the Latin American Stroke Registry (LASE)

2021 , Virginia Pujol-Lereis , Alan F Flores , Antonio Arauz , Carlos Abanto , Pablo Amaya , Hernan Bayona , Pablo Bonardo , Luis Diaz-Escobar , Maia Gomez-Schneider , Fernando Góngora-Rivera , LAVADOS GERMAIN, PABLO MANUEL , Carolina León , Adriana Luraschi , Juan Manuel Márquez-Romero , Sheila CO Martins , Victor Hugo Navia , Angelica Ruiz-Franco , Miguel Angel Vences , Maria Zurru , Miguel A Barboza , Sebastian F Ameriso

Background: Ischemic stroke has been reported to occur in approximately 5% of COVID-19 patients, although some reports are contradictory. Proposed mechanisms of this association are hypercoagulable state, vasculitis and cardiomyopathy, together with traditional vascular risk factors. We analyzed the frequency and clinical characteristics of COVID-19 positive stroke cases during the first months of the pandemic in Latin America. Methods: A multinational study (7 countries, 18 centers) of patients admitted during the pandemic outbreak (March - June 2020). We assessed acute stroke cases associated to COVID-19 infection. Clinical characteristics, stroke etiology and severity, acute care and functional outcomes, were compared between non-COVID-19 and COVID-19 cases. Results: There were a total of 1037 stroke cases; sixty-two of them (6.0%) were diagnosed with COVID-19 infection. This group consisted of 38 men [61.3%], with a median age of 68 years [IQR 59-79 years]. From these cases, 80.6% were ischemic stroke, 16.1% hemorrhagic stroke, and 1.6% transient ischemic attack and cerebral venous thrombosis respectively. The most common etiology reported for ischemic cases was atherosclerotic large vessel occlusion (30.6% vs. 12.7% in non-COVID cases, p<0.001), and undetermined etiology for hemorrhagic stroke (55.6%). Median NIHSS for COVID-stroke patients was higher (7 IQR 2-16 vs. 5 IQR 2-11, p=0.05). Five (8.1%) patients received acute reperfusion therapy, with no differences in door-to-CT, door-to-needle and door-to-groin times, compared to non-COVID cases. Most characteristics did not differ from those of COVID-19 negative patients. Mortality was higher in COVID-stroke cases (20.9% vs. 9.6%, p<0.001). Conclusions: COVID-19 infection frequency in stroke patients in Latin America is similar to that reported in several series worldwide, with a higher frequency of atherosclerotic ischemic strokes and mortality compared to non COVID-19 strokes

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Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial

2012 , Sanne M Dorhout Mees , Ale Algra , W Peter Vandertop , Fop van Kooten , Hans AJM Kuijsten , Jelis Boiten , Robert J van Oostenbrugge , Rustam Al-Shahi Salman , LAVADOS GERMAIN, PABLO MANUEL , Gabriel JE Rinkel , Walter M van den Bergh

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Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage

2013 , Craig S. Anderson , Emma Heeley , Yining Huang , Jiguang Wang , Christian Stapf , Candice Delcourt , Richard Lindley , Thompson Robinson , LAVADOS GERMAIN, PABLO MANUEL , Bruce Neal , Jun Hata , Hisatomi Arima , Mark Parsons , Yuechun Li , Jinchao Wang , Stephane Heritier , Qiang Li , Mark Woodward , R. John Simes , Stephen M. Davis , John Chalmers

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Specificities of Ischemic Stroke Risk Factors in Arab-Speaking Countries

2017 , Halim Abboud , Leila Sissani , Julien Labreuche , Antonio Arauz , Marie-Germaine Bousser , Alain Bryer , Angel Chamorro , Marc Fisher , Ian Ford , Kim M. Fox , Michael G. Hennerici , LAVADOS GERMAIN, PABLO MANUEL , Ayrton Massaro , Heinrich P. Mattle , Mario Munoz Collazos , Peter M. Rothwell , Philippe Gabriel Steg , Eric Vicaut , Bassem Yamouth , Pierre Amarenco

<b><i>Background:</i></b> Stroke is largely preventable, and therefore, a better understanding of risk factors is an essential step in reducing the population stroke rate and resulting disease burden in Arab countries. <b><i>Summary:</i></b> We performed 2 separate analyses in 2 similar populations of patients with noncardioembolic ischemic stroke. This first involved 3,635 patients in the Outcomes in Patients with TIA and Cerebrovascular disease (OPTIC) registry (followed for 2 years), with baseline collection of the usual risk factors and 5 socioeconomic variables (unemployment status, residence in rural area, living in fully serviced accommodation, no health-insurance coverage, and low educational level). The second involved patients in the PERFORM trial (<i>n</i> = 19,100 followed up for 2 years), with baseline collection of the usual risk factors and 1 socioeconomic variable (low educational level). The primary outcome was a composite of nonfatal stroke, nonfatal myocardial infarction, or cardiovascular death. Stroke risk factors were more prevalent in patients in Arab countries. The incidence of major cardiovascular events (MACE; age- and gender-adjusted) was higher in Arab countries (OPTIC, 18.5 vs. 13.3%; PERFORM, 18.4 vs. 9.7%; both <i>p </i>≤ 0.0001). These results remained significant after adjustment on risk factors and were attenuated in OPTIC after further adjustment on socioeconomic variables (hazard ratio 1.24; 95% CI 0.98-1.55; <i>p </i>= 0.07). <b><i>Key Messages:</i></b> Patients with ischemic stroke living in Arab countries had a lower mean socioeconomic status, a much higher prevalence of diabetes mellitus, and a higher rate of MACE compared with patients from non-Arab countries. This finding is partly explained by a higher prevalence of risk factors and also by a high prevalence of poverty and low educational level.

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Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke

2017 , Craig S. Anderson , Hisatomi Arima , LAVADOS GERMAIN, PABLO MANUEL , Laurent Billot , Maree L. Hackett , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , MUÑOZ VENTURELLI, PAULA ANDREA , BRUNSER RABOVICH, ALEJANDRO MICHEL , Bin Peng , Liying Cui , Lily Song , Kris Rogers , Sandy Middleton , Joyce Y. Lim , Denise Forshaw , C. Elizabeth Lightbody , Mark Woodward , Octavio Pontes-Neto , H. Asita De Silva , Ruey-Tay Lin , Tsong-Hai Lee , Jeyaraj D. Pandian , Gillian E. Mead , Thompson Robinson , Caroline Watkins

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Incidence of aphasia in patients experiencing an ischemic stroke

2017 , Francisca González Mc , Pablo Lavados G , Verónica arría I

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Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

2016 , Nicholas J Kassebaum , Megha Arora , Ryan M Barber , Zulfiqar A Bhutta , Jonathan Brown , Austin Carter , Daniel C Casey , Fiona J Charlson , Matthew M Coates , Megan Coggeshall , Leslie Cornaby , Lalit Dandona , Daniel J Dicker , Holly E Erskine , Alize J Ferrari , Christina Fitzmaurice , Kyle Foreman , Mohammad H Forouzanfar , Nancy Fullman , Peter W Gething , Ellen M Goldberg , Nicholas Graetz , Juanita A Haagsma , Simon I Hay , Catherine O Johnson , Laura Kemmer , Ibrahim A Khalil , Yohannes Kinfu , Michael J Kutz , Hmwe H Kyu , Janni Leung , Xiaofeng Liang , Stephen S Lim , Rafael Lozano , George A Mensah , Joe Mikesell , Ali H Mokdad , Meghan D Mooney , Mohsen Naghavi , Grant Nguyen , Elaine Nsoesie , David M Pigott , Christine Pinho , Zane Rankin , Nikolas Reinig , Joshua A Salomon , Logan Sandar , Alison Smith , Reed J D Sorensen , Jeffrey Stanaway , Caitlyn Steiner , Stephanie Teeple , Chris Troeger , Thomas Truelsen , Amelia VanderZanden , Joseph A Wagner , Valentine Wanga , Harvey A Whiteford , Maigeng Zhou , Leo Zoeckler , Amanuel Alemu Abajobir , Kalkidan Hassen Abate , Cristiana Abbafati , Kaja M Abbas , Foad Abd-Allah , Biju Abraham , Ibrahim Abubakar , Laith J Abu-Raddad , Niveen M E Abu-Rmeileh , Tom Achoki , Ilana N Ackerman , Akindele Olupelumi Adebiyi , Isaac Akinkunmi Adedeji , José C Adsuar , Kossivi Agbelenko Afanvi , Ashkan Afshin , Emilie Elisabet Agardh , Arnav Agarwal , Sanjay Kumar Agarwal , Muktar Beshir Ahmed , Aliasghar Ahmad Kiadaliri , Hamid Ahmadieh , Nadia Akseer , Ziyad Al-Aly , Khurshid Alam , Noore K M Alam , Saleh Fahed Aldhahri , Miguel Angel Alegretti , Alicia V Aleman , Zewdie Aderaw Alemu , Lily T Alexander , Raghib Ali , Ala'a Alkerwi , François Alla , Peter Allebeck , Christine Allen , Ubai Alsharif , Khalid A Altirkawi , Elena Alvarez Martin , Nelson Alvis-Guzman , Azmeraw T Amare , Alemayehu Amberbir , Adeladza Kofi Amegah , Heresh Amini , Walid Ammar , Stephen Marc Amrock , Gregory M Anderson , Benjamin O Anderson , Carl Abelardo T Antonio , Palwasha Anwari , Johan Ärnlöv , Valentina S Arsic Arsenijevic , Al Artaman , Hamid Asayesh , Rana Jawad Asghar , Euripide Frinel G Arthur Avokpaho , Ashish Awasthi , Beatriz Paulina Ayala Quintanilla , Peter Azzopardi , Umar Bacha , Alaa Badawi , Kalpana Balakrishnan , Amitava Banerjee , Aleksandra Barac , Suzanne L Barker-Collo , Till Bärnighausen , Lars Barregard , Lope H Barrero , Sanjay Basu , Tigist Assefa Bayou , Justin Beardsley , Neeraj Bedi , Ettore Beghi , Brent Bell , Michelle L Bell , Corina Benjet , Derrick A Bennett , Isabela M Bensenor , Adugnaw Berhane , Eduardo Bernabé , Balem Demtsu Betsu , Addisu Shunu Beyene , Neeraj Bhala , Anil Bhansali , Samir Bhatt , Sibhatu Biadgilign , Kelly Bienhoff , Boris Bikbov , Aref A Bin Abdulhak , Stan Biryukov , Donal Bisanzio , Espen Bjertness , Jed D Blore , Rohan Borschmann , Soufiane Boufous , Rupert R A Bourne , Michael Brainin , Alexandra Brazinova , Nicholas J K Breitborde , Traolach S Brugha , Rachelle Buchbinder , Geoffrey Colin Buckle , Zahid A Butt , Bianca Calabria , Ismael Ricardo Campos-Nonato , Julio Cesar Campuzano , Hélène Carabin , Jonathan R Carapetis , Rosario Cárdenas , Juan Jesus Carrero , Carlos A Castañeda-Orjuela , Jacqueline Castillo Rivas , Ferrán Catalá-López , Fiorella Cavalleri , Jung-Chen Chang , Peggy Pei-Chia Chiang , Mirriam Chibalabala , Chioma Ezinne Chibueze , Vesper Hichilombwe Chisumpa , Jee-Young Jasmine Choi , Lincoln Choudhury , Hanne Christensen , Liliana G Ciobanu , Valentina Colistro , Mercedes Colomar , Samantha M Colquhoun , Monica Cortinovis , John A Crump , Albertino Damasceno , Rakhi Dandona , Paul I Dargan , José das Neves , Gail Davey , Adrian C Davis , Diego De Leo , Louisa Degenhardt , Liana C Del Gobbo , Sarah Derrett , Don C Des Jarlais , Gabrielle A deVeber , Samath D Dharmaratne , Preet K Dhillon , Eric L Ding , Kerrie E Doyle , Tim R Driscoll , Leilei Duan , Manisha Dubey , Bruce Bartholow Duncan , Hedyeh Ebrahimi , Richard G Ellenbogen , Iqbal Elyazar , Aman Yesuf Endries , Sergey Petrovich Ermakov , Babak Eshrati , Alireza Esteghamati , Kara Estep , Saman Fahimi , Talha A Farid , Carla Sofia e Sa Farinha , André Faro , Maryam S Farvid , Farshad Farzadfar , Valery L Feigin , Seyed-Mohammad Fereshtehnejad , Jefferson G Fernandes , Joao C Fernandes , Florian Fischer , Joseph R A Fitchett , Nataliya Foigt , F Gerry R Fowkes , Richard C Franklin , Joseph Friedman , Joseph Frostad , Thomas Fürst , Neal D Futran , Belinda Gabbe , Fortuné Gbètoho Gankpé , Alberto L Garcia-Basteiro , Tsegaye Tewelde Gebrehiwot , Amanuel Tesfay Gebremedhin , Johanna M Geleijnse , Katherine B Gibney , Richard F Gillum , Ibrahim Abdelmageem Mohamed Ginawi , Ababi Zergaw Giref , Maurice Giroud , Melkamu Dedefo Gishu , Giorgia Giussani , William W Godwin , Hector Gomez-Dantes , Philimon Gona , Amador Goodridge , Sameer Vali Gopalani , Carolyn C Gotay , Atsushi Goto , Hebe N Gouda , Harish Gugnani , Yuming Guo , Rahul Gupta , Rajeev Gupta , Vipin Gupta , Reyna A Gutiérrez , Nima Hafezi-Nejad , Demewoz Haile , Alemayehu Desalegne Hailu , Gessessew Bugssa Hailu , Yara A Halasa , Randah Ribhi Hamadeh , Samer Hamidi , Mouhanad Hammami , Alexis J Handal , Graeme J Hankey , Hilda L Harb , Sivadasanpillai Harikrishnan , Josep Maria Haro , Mohammad Sadegh Hassanvand , Tahir Ahmed Hassen , Rasmus Havmoeller , Roderick J Hay , Mohammad T Hedayati , Ileana Beatriz Heredia-Pi , Pouria Heydarpour , Hans W Hoek , Daniel J Hoffman , Masako Horino , Nobuyuki Horita , H Dean Hosgood , Damian G Hoy , Mohamed Hsairi , Hsiang Huang , John J Huang , Kim Moesgaard Iburg , Bulat T Idrisov , Kaire Innos , Manami Inoue , Kathryn H Jacobsen , Alejandra Jauregui , Achala Upendra Jayatilleke , Panniyammakal Jeemon , Vivekanand Jha , Guohong Jiang , Ying Jiang , Tariku Jibat , Aida Jimenez-Corona , Ye Jin , Jost B Jonas , Zubair Kabir , Dan K Kajungu , Yogeshwar Kalkonde , Ritul Kamal , Haidong Kan , Amit Kandel , André Karch , Corine Kakizi Karema , Chante Karimkhani , Amir Kasaeian , Marzieh Katibeh , Anil Kaul , Norito Kawakami , Dhruv S Kazi , Peter Njenga Keiyoro , Andrew Haddon Kemp , Andre Pascal Kengne , Andre Keren , Chandrasekharan Nair Kesavachandran , Yousef Saleh Khader , Abdur Rahman Khan , Ejaz Ahmad Khan , Young-Ho Khang , Tawfik Ahmed Muthafer Khoja , Jagdish Khubchandani , Christian Kieling , Cho-il Kim , Daniel Kim , Yun Jin Kim , Niranjan Kissoon , Miia Kivipelto , Luke D Knibbs , Ann Kristin Knudsen , Yoshihiro Kokubo , Dhaval Kolte , Jacek A Kopec , Parvaiz A Koul , Ai Koyanagi , Barthelemy Kuate Defo , Ricardo S Kuchenbecker , Burcu Kucuk Bicer , Ernst J Kuipers , G Anil Kumar , Gene F Kwan , Ratilal Lalloo , Tea Lallukka , Anders Larsson , Asma Abdul Latif , LAVADOS GERMAIN, PABLO MANUEL , Alicia Elena Beatriz Lawrynowicz , Janet L Leasher , James Leigh , Ricky Leung , Yichong Li , Yongmei Li , Steven E Lipshultz , Patrick Y Liu , Yang Liu , Belinda K Lloyd , Giancarlo Logroscino , Katharine J Looker , Paulo A Lotufo , Robyn M Lucas , Raimundas Lunevicius , Ronan A Lyons , Hassan Magdy Abd El Razek , Mahdi Mahdavi , Marek Majdan , Azeem Majeed , Reza Malekzadeh , Deborah Carvalho Malta , Wagner Marcenes , Jose Martinez-Raga , Felix Masiye , Amanda J Mason-Jones , Richard Matzopoulos , Bongani M Mayosi , John J McGrath , Martin McKee , Peter A Meaney , Alem Mehari , Yohannes Adama Melaku , Peter Memiah , Ziad A Memish , Walter Mendoza , Atte Meretoja , Tuomo J Meretoja , Yonatan Moges Mesfin , Francis Apolinary Mhimbira , Anoushka Millear , Ted R Miller , Edward J Mills , Mojde Mirarefin , Erkin M Mirrakhimov , Philip B Mitchell , Charles N Mock , Karzan Abdulmuhsin Mohammad , Alireza Mohammadi , Shafiu Mohammed , Lorenzo Monasta , Julio Cesar Montañez Hernandez , Marcella Montico , Maziar Moradi-Lakeh , Rintaro Mori , Ulrich O Mueller , John Everett Mumford , Michele E Murdoch , Gudlavalleti Venkata Satyanarayana Murthy , Jean B Nachega , Aliya Naheed , Luigi Naldi , Vinay Nangia , John N Newton , Marie Ng , Frida Namnyak Ngalesoni , Quyen Le Nguyen , Muhammad Imran Nisar , Patrick Martial Nkamedjie Pete , Joan M Nolla , Ole F Norheim , Rosana E Norman , Bo Norrving , Carla Makhlouf Obermeyer , Felix Akpojene Ogbo , In-Hwan Oh , Olanrewaju Oladimeji , Pedro R Olivares , Bolajoko Olubukunola Olusanya , Jacob Olusegun Olusanya , Eyal Oren , Alberto Ortiz , Erika Ota , Abayomi Samuel Oyekale , Mahesh PA , Eun-Kee Park , Mahboubeh Parsaeian , Scott B Patten , George C Patton , João Mário Pedro , David M Pereira , Norberto Perico , Konrad Pesudovs , Max Petzold , Michael Robert Phillips , Frédéric B Piel , Julian David Pillay , Farhad Pishgar , Dietrich Plass , Suzanne Polinder , Svetlana Popova , Richie G Poulton , Farshad Pourmalek , Noela M Prasad , Mostafa Qorbani , Rynaz H S Rabiee , Amir Radfar , Anwar Rafay , Kazem Rahimi , Vafa Rahimi-Movaghar , Mahfuzar Rahman , Mohammad Hifz Ur Rahman , Sajjad Ur Rahman , Dheeraj Rai , Rajesh Kumar Rai , Sasa Rajsic , Murugesan Raju , Usha Ram , Kavitha Ranganathan , Amany H Refaat , Marissa B Reitsma , Giuseppe Remuzzi , Serge Resnikoff , Alex Reynolds , Antonio L Ribeiro , Stefano Ricci , Hirbo Shore Roba , David Rojas-Rueda , Luca Ronfani , Gholamreza Roshandel , Gregory A Roth , Ambuj Roy , Ben Benasco Sackey , Rajesh Sagar , Juan R Sanabria , Maria Dolores Sanchez-Niño , Itamar S Santos , João Vasco Santos , Rodrigo Sarmiento-Suarez , Benn Sartorius , Maheswar Satpathy , Miloje Savic , Monika Sawhney , Maria Inês Schmidt , Ione J C Schneider , Aletta E Schutte , David C Schwebel , Soraya Seedat , Sadaf G Sepanlou , Edson E Servan-Mori , Saeid Shahraz , Masood Ali Shaikh , Rajesh Sharma , Jun She , Sara Sheikhbahaei , Jiabin Shen , Kevin N Sheth , Kenji Shibuya , Mika Shigematsu , Min-Jeong Shin , Rahman Shiri , Inga Dora Sigfusdottir , Diego Augusto Santos Silva , Jonathan I Silverberg , Edgar P Simard , Abhishek Singh , Jasvinder A Singh , Prashant Kumar Singh , Vegard Skirbekk , Jens Christoffer Skogen , Michael Soljak , Kjetil Søreide , Reed J D Sorensen , Chandrashekhar T Sreeramareddy , Vasiliki Stathopoulou , Nicholas Steel , Dan J Stein , Murray B Stein , Timothy J Steiner , Lars Jacob Stovner , Saverio Stranges , Konstantinos Stroumpoulis , Bruno F Sunguya , Patrick J Sur , Soumya Swaminathan , Bryan L Sykes , Cassandra E I Szoeke , Rafael Tabarés-Seisdedos , Nikhil Tandon , David Tanne , Mohammad Tavakkoli , Bineyam Taye , Hugh R Taylor , Braden J Te Ao , Teketo Kassaw Tegegne , Dejen Yemane Tekle , Abdullah Sulieman Terkawi , Gizachew Assefa Tessema , J S Thakur , Alan J Thomson , Andrew L Thorne-Lyman , Amanda G Thrift , George D Thurston , Ruoyan Tobe-Gai , Marcello Tonelli , Roman Topor-Madry , Fotis Topouzis , Bach Xuan Tran , Thomas Truelsen , Zacharie Tsala Dimbuene , Miltiadis Tsilimbaris , Abera Kenay Tura , Emin Murat Tuzcu , Stefanos Tyrovolas , Kingsley N Ukwaja , Eduardo A Undurraga , Chigozie Jesse Uneke , Olalekan A Uthman , Coen H van Gool , Jim van Os , Tommi Vasankari , Ana Maria Nogales Vasconcelos , Narayanaswamy Venketasubramanian , Francesco S Violante , Vasiliy Victorovich Vlassov , Stein Emil Vollset , Gregory R Wagner , Mitchell T Wallin , Linhong Wang , Scott Weichenthal , Elisabete Weiderpass , Robert G Weintraub , Andrea Werdecker , Ronny Westerman , Tissa Wijeratne , James D Wilkinson , Hywel C Williams , Charles Shey Wiysonge , Solomon Meseret Woldeyohannes , Charles D A Wolfe , Sungho Won , Gelin Xu , Ajit Kumar Yadav , Bereket Yakob , Lijing L Yan , Yuichiro Yano , Mehdi Yaseri , Pengpeng Ye , Paul Yip , Naohiro Yonemoto , Seok-Jun Yoon , Mustafa Z Younis , Chuanhua Yu , Zoubida Zaidi , Maysaa El Sayed Zaki , Hajo Zeeb , Sanjay Zodpey , David Zonies , Liesl Joanna Zuhlke , Theo Vos , Alan D Lopez , Christopher J L Murray

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Who is in the emergency room matters when we talk about door-to-needle time: a single-center experience

2023 , BRUNSER RABOVICH, ALEJANDRO MICHEL , Juan-Cristobal Nuñez , Eloy Mansilla , Gabriel Cavada , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , MUÑOZ VENTURELLI, PAULA ANDREA , LAVADOS GERMAIN, PABLO MANUEL

Abstract Background The efficacy of intravenous thrombolysis (IVT) is time-dependent. Objective To compare the door-to-needle (DTN) time of stroke neurologists (SNs) versus non-stroke neurologists (NSNs) and emergency room physicians (EPs). Additionally, we aimed to determine elements associated with DTN ≤ 20 minutes. Methods Prospective study of patients with IVT treated at Clínica Alemana between June 2016 and September 2021. Results A total of 301 patients underwent treatment for IVT. The mean DTN time was 43.3 ± 23.6 minutes. One hundred seventy-three (57.4%) patients were evaluated by SNs, 122 (40.5%) by NSNs, and 6 (2.1%) by EPs. The mean DTN times were 40.8 ± 23, 46 ± 24.7, and 58 ± 22.5 minutes, respectively. Door-to-needle time ≤ 20 minutes occurred more frequently when patients were treated by SNs compared to NSNs and EPs: 15%, 4%, and 0%, respectively (odds ratio [OR]: 4.3, 95% confidence interval [95%CI]: 1.66–11.5, p = 0.004). In univariate analysis DTN time ≤ 20 minutes was associated with treatment by a SN (p = 0.002), coronavirus disease 2019 pandemic period (p = 0.21), time to emergency room (ER) (p = 0.21), presence of diabetes (p = 0.142), hypercholesterolemia (p = 0.007), atrial fibrillation (p < 0.09), score on the National Institutes of Health Stroke Scale (NIHSS) (p = 0.001), lower systolic (p = 0.143) and diastolic (p = 0.21) blood pressures, the Alberta Stroke Program Early CT Score (ASPECTS; p = 0.09), vessel occlusion (p = 0.05), use of tenecteplase (p = 0.18), thrombectomy (p = 0.13), and years of experience of the physician (p < 0.001). After multivariate analysis, being treated by a SN (OR: 3.95; 95%CI: 1.44–10.8; p = 0.007), NIHSS (OR: 1.07; 95%CI: 1.02–1.12; p < 0.002) and lower systolic blood pressure (OR: 0.98; 95%CI: 0.96–0.99; p < 0.003) remained significant. Conclusion Treatment by a SN resulted in a higher probability of treating the patient in a DTN time within 20 minutes.

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Minimum intravenous thrombolysis utilization rates in acute ischemic stroke to achieve population effects on disability: A discrete-event simulation model

2016 , Lorena Hoffmeister , LAVADOS GERMAIN, PABLO MANUEL , Javier Mar , Merce Comas , Arantzazu Arrospide , Xavier Castells

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Stroke symptoms, risk factors awareness and personal decision making in Chile. A national survey

2022 , NAVIA GONZALEZ, VICTOR HUGO , MAZZON AGURTO, ENRICO , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , ALMEIDA TORO, JUAN MANUEL , BRUNSER, ALEJANDRO , LAVADOS GERMAIN, PABLO MANUEL , HOFFMEISTER ARCE, LORENA , MUÑOZ VENTURELLI, PAULA ANDREA

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