BILLEKE BOBADILLA, PABLO ERNESTO
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BILLEKE BOBADILLA, PABLO ERNESTO
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pbilleke@udd.cl
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8229414600

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Dataset - Differences in cortical processing of facial emotions in broader autism phenotype

2020 , BILLEKE BOBADILLA, PABLO ERNESTO , SOTO ICAZA, PATRICIA

Autism Spectrum Disorder (ASD) is a heterogeneous condition that affects face perception. Evidence shows that there are differences in face perception associated with the processing of low spatial frequency (LSF) and high spatial frequency (HSF) of visual stimuli between non-symptomatic relatives of individuals with autism (broader autism phenotype, BAP) and typically developing individuals. However, the neural mechanisms involved in these differences are not fully understood. Here we tested whether face-sensitive event related potentials could serve as neuronal markers of differential spatial frequency processing, and whether these potentials could differentiate non-symptomatic parents of children with autism (pASD) from parents of typically developing children (pTD). To this end, we performed electroencephalographic recordings of both groups of parents while they had to recognize emotions of face pictures composed of the same or different emotions (happiness or anger) presented in different spatial frequencies. We found no significant differences in the accuracy between groups but lower amplitude modulation in the Late Positive Potential activity in pASD. Source analysis showed a difference in the right posterior part of the superior temporal region that correlated with ASD symptomatology of the child. These results reveal differences in brain processing of recognition of facial emotion in BAP that could be a precursor of ASD.

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The More I Get to Know You, the More I Distrust You? Non-linear Relationship between Social Skills and Social Behavior

2016 , BILLEKE BOBADILLA, PABLO ERNESTO

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Neural Dynamics of Improved Bimodal Attention and Working Memory in Musically Trained Children

2020 , Leonie Kausel , Francisco Zamorano , BILLEKE BOBADILLA, PABLO ERNESTO , Mary E. Sutherland , Josefina Larrain-Valenzuela , Gottfried Schlaug , STECHER GUZMAN, XIMENA PATRICIA , Francisco Aboitiz

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Paradoxical Expectation: Oscillatory Brain Activity Reveals Social Interaction Impairment in Schizophrenia

2015 , BILLEKE BOBADILLA, PABLO ERNESTO , Alejandra Armijo , Daniel Castillo , Tamara López , ZAMORANO m, FRANCISCO JAVIER , Diego Cosmelli , Francisco Aboitiz

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Beta oscillations precede joint attention and correlate with mentalization in typical development and autism

2019 , SOTO ICAZA, PATRICIA , Lorena Vargas , Francisco Aboitiz , BILLEKE BOBADILLA, PABLO ERNESTO

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Gender gaps in the quality education measurement system (SIMCE) tests and in the university selection tests (PSU) outcomes in chilean school-age children: An eight-year follow-up study

2020 , Ivanovic, Daniza M. , Orellana, Yasna Z. , Leyton, Bárbara D. , Arancibia, Violeta C. , Almagià, Atilio F. , Valenzuela, Rodrigo B. , Barrera, Cynthia R. , BILLEKE BOBADILLA, PABLO ERNESTO , ZAMORANO MENDIETA, FRANCISCO JAVIER , Silva, Claudio F. A. , Larraín, Cristián G. , Carreño, John S.

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Brain structural parameters correlate with University Selection Test outcomes in Chilean high school graduates

2022 , Daniza Ivanovic , ZAMORANO M, FRANCISCO JAVIER , SOTO ICAZA, PATRICIA , Tatiana Rojas , Atilio Almagià , SILVA FUENTE ALBA, CLAUDIO SERGIO , Claudia Bustamante , Violeta Arancibia , Francisca Villagrán , Rodrigo Valenzuela , Cynthia Barrera , Cristián Larraín , BILLEKE BOBADILLA, PABLO ERNESTO

AbstractHow well students learn and perform in academic contexts is a focus of interest for the students, their families, and the entire educational system. Although evidence has shown that several neurobiological factors are involved in scholastic achievement (SA), specific brain measures associated with academic outcomes and whether such associations are independent of other factors remain unclear. This study attempts to identify the relationship between brain structural parameters, and the Chilean national University Selection Test (PSU) results in high school graduates within a multidimensional approach that considers socio-economic, intellectual, nutritional, and demographic variables. To this end, the brain morphology of a sample of 102 students who took the PSU test was estimated using Magnetic Resonance Imaging. Anthropometric parameters, intellectual ability (IA), and socioeconomic status (SES) were also measured. The results revealed that, independently of sex, IA, gray matter volume, right inferior frontal gyrus thickness, and SES were significantly associated with SA. These findings highlight the role of nutrition, health, and socioeconomic variables in academic success.

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Sub-visemic discrimination and the effect of visual resemblance on silent lip-reading

2024 , Maëva Michon , BILLEKE BOBADILLA, PABLO ERNESTO , Gabriela Galgani , Francisco Aboitiz

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The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial

2024 , Alejandra Figueroa-Vargas , Begoña Góngora , María Francisca Alonso , Alonso Ortega , Patricio Soto-Fernández , Lucía Z-Rivera , Sebastián Ramírez , Francisca González , MUÑOZ VENTURELLI, PAULA ANDREA , BILLEKE BOBADILLA, PABLO ERNESTO

Abstract Background The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia and mild cognitive impairment (MCI). The latter can be considered a prodromal phase of some dementias and a critical stage for interventions to postpone the impairment of functionality. Working memory (WM) is a pivotal cognitive function, representing the fundamental element of executive functions. This project proposes an intervention protocol to enhance WM in these users, combining cognitive training with transcranial electrical stimulation of alternating current (tACS). This technique has been suggested to enhance the neuronal plasticity needed for cognitive processes involving oscillatory patterns. WM stands to benefit significantly from this approach, given its well-defined electrophysiological oscillations. Therefore, tACS could potentially boost WM in patients with neurodegenerative diseases. Methods This study is a phase IIb randomised, double-blind clinical trial with a 3-month follow-up period. The study participants will be 62 participants diagnosed with MCI, aged over 60, from Valparaíso, Chile. Participants will receive an intervention combining twelve cognitive training sessions with tACS. Participants will receive either tACS or placebo stimulation in eight out of twelve training sessions. Sessions will occur twice weekly over 6 weeks. The primary outcomes will be electroencephalographic measurements through the prefrontal theta oscillatory activity, while the secondary effects will be cognitive assessments of WM. The participants will be evaluated before, immediately after, and 3 months after the end of the intervention. Discussion The outcomes of this trial will add empirical evidence about the benefits and feasibility of an intervention that combines cognitive training with non-invasive brain stimulation. The objective is to contribute tools for optimal cognitive treatment in patients with MCI. To enhance WM capacity, postpone the impairment of functionality, and obtain a better quality of life. Trial registration ClinicalTrials.gov NCT05291208. Registered on 28 February 2022. ISRCTN87597719 retrospectively registered on 15 September 2023.

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Perfil cognitivo en el Mareo Perceptual Postural Persistente: Implicancias sobre su fisiopatología como disfunción cognitiva viso-vestibular superior

2023 , Kevin Alarcón P. , Camilo Arévalo-Romero , Karen Villarroel , Claudio Lavín , Felipe Faúndez , Rosario Garrido , BILLEKE BOBADILLA, PABLO ERNESTO , Hayo Breinbauer K.

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