SILVA GONZALEZ, NATALY ROXANA
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SILVA GONZALEZ, NATALY ROXANA
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nrsilva@udd.cl
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Scopus Author ID
35176687400

Research Output

2024 2024 2023 2023 0.0 0.0 0.5 0.5 1.0 1.0 1.5 1.5 2.0 2.0 2.5 2.5 3.0 3.0

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Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

2024 , Sebastián Salazar Sandoval , Patricia Díaz-Saldívar , Ingrid Araya , Freddy Celis , Diego Cortés-Arriagada , Ana Riveros , Carlos Rojas-Romo , Carolina Jullian , SILVA GONZALEZ, NATALY ROXANA , Nicolás Yutronic , Marcelo J. Kogan , Paul Jara

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Review on Generation and Characterization of Copper Particles and Copper Composites Prepared by Mechanical Milling on a Lab-Scale

2023 , Sebastián Salazar Sandoval , SILVA GONZALEZ, NATALY ROXANA

This review aims to expose mechanical milling as an alternative method for generating copper-based particles (copper particles (CuP) and copper composites (CuC)); more specifically, via a top-down or bottom-up approach, on a lab-scale. This work will also highlight the different parameters that can affect the size distribution, the type, and the morphology of the obtained CuP or CuC, such as the type of mechanical mill, ball-to-powder ratios (BPR), the milling speed, milling time, and the milling environment, among others. This review analyzes various papers based on the Cu-based particle generation route, which begins with a pretreatment step, then mechanical milling, its approach (top-down or bottom-up), and the post-treatment. Finally, the characterization methods of the resulting CuP and CuC through mechanical milling are also discussed.

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β-Cyclodextrin Nanosponges Inclusion Compounds Associated with Silver Nanoparticles to Increase the Antimicrobial Activity of Quercetin

2023 , Sebastián Salazar Sandoval , Tamara Bruna , Francisca Maldonado-Bravo , Karen Bolaños , Sofía Adasme-Reyes , Ana Riveros , Nelson Caro , Nicolás Yutronic , SILVA GONZALEZ, NATALY ROXANA , Marcelo J. Kogan , Paul Jara

This work aimed to synthesize and characterize a nanocarrier that consisted of a ternary system, namely β-cyclodextrin-based nanosponge (NS) inclusion compounds (ICs) associated with silver nanoparticles (AgNPs) to increase the antimicrobial activity of quercetin (QRC). The nanosystem was developed to overcome the therapeutical limitations of QRC. The host–guest interaction between NSs and QRC was confirmed by field emission scanning electron microscopy (FE–SEM), X-ray powder diffraction (XRPD), thermogravimetric analysis (TGA), and proton nuclear magnetic resonance (1H–NMR). Moreover, the association of AgNPs with the NS–QRC was characterized using FE–SEM, energy-dispersive spectroscopy (EDS), transmission electron microscopy (TEM), dynamic light scattering (DLS), ζ-potential, and UV–Vis. Finally, the antimicrobial activity of the novel formulations was tested, which depicted that the complexation of QRC inside the supramolecular interstices of NSs increases the inhibitory effects against Escherichia coli ATCC25922, as compared to that observed in the free QRC. In addition, at the same concentrations used to generate an antibacterial effect, the NS–QRC system with AgNPs does not affect the metabolic activity of GES–1 cells. Therefore, these results suggest that the use of NSs associated with AgNPs resulted in an efficient strategy to improve the physicochemical features of QRC.

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Advances in the Sustainable Development of Biobased Materials Using Plant and Animal Waste as Raw Materials: A Review

2024 , Sebastián Salazar Sandoval , AMENÁBAR FIGUEROA, ALEJANDRA , TOLEDO ROMÁN, IGNACIO GALVARINO , SILVA GONZALEZ, NATALY ROXANA , CONTRERAS CORREA, PAULINA DEL PILAR

There is substantial concern about critical environmental problems related to waste in production sectors such as textile, construction, and packaging. The materials ascribed to the sector’s unsustainability are primarily fabrics, plastic, and hazardous solvents, making developing new biobased materials imperative. As such, various strategies have been investigated to convert and recycle waste and give them commercial value via the manufacture of biobased materials. This review discusses the various types of raw materials as sources to develop new biobased materials that could promote the transition toward sustainability. According to the literature, the functional qualities of biobased materials are comparable to those of synthetic materials. Raw material sources such as biomass, derived from plant and animal-based waste, are attractive due to their low cost, abundance, and biodegradability. The manufacture of biomaterials, as well as their characterization and performance, are also discussed. Further, this review will offer a comprehensive view of the potential applicability and current commercial applications of the developed biobased materials in relevant areas such as packaging, construction, textile, and wastewater remediation. This could be a potential field of research to address the environmental challenges posed by the continuous growth of the global population.

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Synthesis and Characterization of Magnetite/Gold Core Shell Nanoparticles Stabilized with a β-Cyclodextrin Nanosponge to Develop a Magneto-Plasmonic System

2023 , Sebastián Salazar Sandoval , Daniel Santibáñez , Ana Riveros , Fabián Araneda , Tamara Bruna , SILVA GONZALEZ, NATALY ROXANA , Nicolás Yutronic , Marcelo J. Kogan , Paul Jara

Magnetite/gold core-shell nanoparticles (magnetite/gold NPs) have important optical and magnetic properties that provide potential for applications, especially biomedical ones. However, their preparation is not exempt from difficulties that might lead to unexpected or undesired structures. This work reports the synthesis and characterization of magnetite/gold NPs using tetramethylammonium hydroxide (TMAH) to promote the formation of a continuous interface between the magnetite core and the thin gold shell. The synthesized magnetite/gold NPs were characterized using transmission electron microscopy (TEM), energy-dispersive spectroscopy (EDS), field emission scanning electron microscope (FE-SEM), ζ-potential, vibrating sample magnetometer (VSM), selected area electron diffraction (SAED), UV-Visible spectroscopy, and dynamic light scattering (DLS), confirming the core-shell structure of the NPs with narrow size distribution while evidencing its plasmonic and superparamagnetic properties as well. Further, the magnetite/gold NPs were associated and stabilized with a β-cyclodextrin nanosponge (β-CDNSs), obtaining a versatile magneto-plasmonic system for potential applications in the encapsulation and controlled release of drugs.

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