BEHRENS PELLEGRINO, MARIA ISABEL
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BEHRENS PELLEGRINO, MARIA ISABEL
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BEHRENS PELLEGRINO, MARIA ISABEL
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mbehrens@udd.cl
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7007110355

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Motor pathway excitability in ATP13A2 mutation carriers: A transcranial magnetic stimulation study

2012 , S. Zittel , J. Kroeger , J.P.M. van der Vegt , H.R. Siebner , N. Brüggemann , A. Ramirez , BEHRENS PELLEGRINO, MARIA ISABEL , C. Gerloff , T. Bäumer , C. Klein , A. Münchau

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Vitamin D Increases Aβ140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients

2018 , Carol D. SanMartín , Mauricio Henriquez , Carlos Chacon , Daniela P. Ponce , Felipe Salech , Nicole K. Rogers , BEHRENS PELLEGRINO, MARIA ISABEL

Background: Mild cognitive impairment (MCI) has an increased rate of progression to dementia. Alterations of some metabolic factors, such as deficiency of vitamin D, are a risk factor for cognitive deterioration. Vitamin D is involved in the clearance of β-amyloid (Aβ) from the brain. We have reported that lymphocytes from Alzheimer's disease (AD) patients have an increased susceptibility to oxidative death by H2O2 exposure, but currently it is unknown if this characteristic is modifiable in vivo. Objective: To determine if correction of low vitamin D levels protects lymphocytes from oxidative death and increases Aβ1-40 plasma levels in MCI and very early AD (VEAD) patients. Method: Sixteen MCI, 11 VEAD and 25 healthy control (HC) voluntaries were evaluated with the Clinical Dementia Rating (CDR), Montreal Cognitive assessment (MoCA), and Memory Index score (MIS). Lymphocyte death was measured by flow cytometry after 20h exposure to H2O2. In patients with low levels of vitamin D -11 MCI, 9 VEAD and 20 HC- lymphocyte H2O2-death, plasma Aβ1-40 levels and cognitive status were evaluated pre- and post-vitamin D supplementation for 6 months. Results: Lymphocytes from MCI and VEAD patients showed increased susceptibility to oxidative death at study entry. In MCI, but not VEAD patients, lymphocyte susceptibility to death and Aβ1-40 levels plasma levels improved after 6 months of vitamin D supplementation. In addition, cognitive status on follow-up (18 months) improved in MCI patients after vitamin D supplementation. Conclusion: Vitamin D supplementation may be beneficial in MCI. The lack of effect in VEAD may be due to a more advanced stage or different characteristics of the neurodegenerative process.

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PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients

2017 , Salech, Felipe , Ponce, Daniela , SanMartín, Carol , Nicole K. Rogers , Carlos Chacón , Mauricio Henríquez , BEHRENS PELLEGRINO, MARIA ISABEL

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Frequency and Determinants of Poststroke Cognitive Impairment at Three and Twelve Months in Chile

2010 , Carolina Delgado , Archibaldo Donoso , Patricia Orellana , Carolina Vásquez , DIAZ TAPIA, VIOLETA DEL CARMEN , BEHRENS PELLEGRINO, MARIA ISABEL

A higher risk of poststroke cognitive impairment (CI) has been reported in Hispanics in a US cohort but has not been systematically studied in Latin America. <i>Objectives:</i> Our purpose was to investigate the frequencies and determinants of poststroke CI in the hispano-mestizo population of Santiago, Chile. <i>Methods:</i> A prospective study of hospitalized patients aged >60 years admitted with an ischemic or hemorrhagic stroke was conducted. The cognitive status was determined at 3 and 12 months after the stroke by informant questionnaires, neuropsychological testing and clinical diagnosis. Cardiovascular risk factors, brain imaging and stroke features were analyzed using regression models to establish determinants for poststroke CI. <i>Results:</i> A total of 164 patients (mean age = 72 ± 7.5 years) were recruited. Out of 122 patients (74%) evaluated at 3 months, 81 (66%) had CI. Out of 101 patients (62%) evaluated at 12 months, 39 (39%) had CI no dementia, and 22 (22%) were demented. The new-onset dementia frequency at 1 year was 16%. Independent determinants for dementia were higher functional impairment at hospital egress (OR = 4.0), left-hemisphere large-vessel infarction (OR = 6.9) and a larger amount of white matter changes (OR = 1.3). <i>Conclusions:</i> In this first study on poststroke CI in Latin America, the frequencies and determinants of poststroke CI were similar to those in other cohorts of different ethnic origin.

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Cancer History Is Associated with Slower Speed of Cognitive Decline in Patients with Amnestic Cognitive Impairment

2022 , Rolando I. Castillo-Passi , Rodrigo C. Vergara , Nicole K. Rogers , Daniela P. Ponce , Magdalena Bennett , BEHRENS PELLEGRINO, MARIA ISABEL

Background: Several epidemiological studies report a negative association between Cancer and Alzheimer’s disease (AD). Objective: To characterize the trajectories of memory loss in individuals with early amnestic cognitive impairment with and without history of previous cancer. Methods: Cognitive deterioration was assessed using the Montreal Cognitive Assessment (MoCA) or MoCA-Memory Index Score (MoCA-MIS) biannually in subjects with early amnestic cognitive impairment followed-up retrospectively from 2007 to 2021. History of Cancer was obtained from clinical records. Simple linear regressions of MoCA-MIS scores were calculated for each subject and analyzed with K-means cluster analysis to identify subgroups with different cognitive decline trajectories. χ2 and t tests were used for descriptive categorical and continuous variables and mixed multiple linear regressions to determine cognitive decline covariates. Results: Analysis of the trajectory of cognitive decline in 141 subjects with early amnestic cognitive impairment identified two subgroups: Fast (n = 60) and Slow (n = 81) progressors. At baseline Fast progressors had better MoCA-MIS (p < 0.001) and functionality (CDR p = 0.02, AD8 p = 0.05), took less anti-dementia medications (p = 0.005), and had higher depression rates (p = 0.02). Interestingly, Fast progressors slowed their speed of memory decline (from 1.6 to 1.1 MoCA-MIS points/year) and global cognitive decline (from 2.0 to 1.4 total MoCA points/year) when Cancer history was present. Conclusion: Two trajectories of amnestic cognitive decline were identified, possibly derived from different neurophysiopathologies or clinical stages. This study suggests that a history of previous Cancer slows down amnestic cognitive decline, specifically in a subgroup of subjects with depression at baseline and accelerated deterioration at follow-up.

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The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science

2021 , Agustin Ibanez , Jennifer S. Yokoyama , Katherine L. Possin , Diana Matallana , Francisco Lopera , Ricardo Nitrini , Leonel T. Takada , Nilton Custodio , Ana Luisa Sosa Ortiz , José Alberto Avila-Funes , BEHRENS PELLEGRINO, MARIA ISABEL , Andrea Slachevsky , Richard M. Myers , J. Nicholas Cochran , Luis Ignacio Brusco , Martin A. Bruno , Sonia M. D. Brucki , Stefanie Danielle Pina-Escudero , Maira Okada de Oliveira , Patricio Donnelly Kehoe , Adolfo M. Garcia , Juan Felipe Cardona , Hernando Santamaria-Garcia , Sebastian Moguilner , Claudia Duran-Aniotz , Enzo Tagliazucchi , Marcelo Maito , Erika Mariana Longoria Ibarrola , Maritza Pintado-Caipa , Maria Eugenia Godoy , Vera Bakman , Shireen Javandel , Kenneth S. Kosik , Victor Valcour , Bruce L. Miller

Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.

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Memoria, fluidez y orientación: prueba de cribado de deterioro cognitivo en 5 minutos

2013 , C. Delgado Derio , S. Guerrero Bonnet , M. Troncoso Ponce , A. Araneda Yañez , SLACHEVSKY CHONCHOL, ANDREA MARÍA , BEHRENS PELLEGRINO, MARIA ISABEL

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Age-Dependent Increases in Apoptosis/Necrosis Ratios in Human Lymphocytes Exposed to Oxidative Stress

2011 , BEHRENS PELLEGRINO, MARIA ISABEL , Silva, Mónica , Schmied, Astrid , Salech, Felipe , Manzur, Hachi , Rolando Rebolledo , Ricardo Bull , Vicente Torres , Mauricio Henriquez , Andrew F. G. Quest

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Biomarkers for dementia in Latin American countries: Gaps and opportunities

2022 , Mario A. Parra , ORELLANA VILLENA, VIVIANA PAULINA , Tomas Leon , Cabello G. Victoria , Rodrigo Gomez , Fernando Henriquez , Constanza Avalos , Andres Damian , Agustin Ibañez , Henrik Zetterberg , SLACHEVSKY CHONCHOL, ANDREA MARÍA , Betty M. Tijms , Jennifer S. Yokoyama , Stefanie D. Piña‐Escudero , J. Nicholas Cochran , Diana L. Matallana , Daisy Acosta , Ricardo Allegri , Bianca P. Arias‐Suárez , Bernardo Barra , Sonia M. D. Brucki , Geraldo Busatto , Paulo Caramelli , Sheila Castro‐Suarez , BEHRENS PELLEGRINO, MARIA ISABEL , Valeria Contreras , Nilton Custodio , Sergio Dansilio , Myriam De la Cruz‐Puebla , Leonardo Cruz de Souza , Monica M. Diaz , Lissette Duque , Gonzalo A. Farías , Sergio T. Ferreira , Nahuel Magrath Guimet , Ana Kmaid , David Lira , Francisco Lopera , Beatriz Mar Meza , Eliane C. Miotto , Ricardo Nitrini , Alberto Nuñez , Santiago O'Neill , John Ochoa , Maritza Pintado‐Caipa , Elisa de Paula França Resende , Shannon Risacher , Luz Angela Rojas , Valentina Sabaj , Lucas Schilling , Allis F. Sellek , Ana Sosa , Leonel T. Takada , Antonio L. Teixeira , Martha Unaucho‐Pilalumbo , Claudia Duran‐Aniotz

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Inverse Relationship Between Alzheimer's Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases.

2019 , Nicole K. Rogers , Cesar Romero , Carol D. SanMartín , Daniela P. Ponce , Felipe Salech , Mercedes N. López , Alejandra Gleisner , Fabián Tempio , BEHRENS PELLEGRINO, MARIA ISABEL

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