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How to Do an Electrophysiological Study of Myoclonus

2022 , VIAL UNDURRAGA, FELIPE AGUSTIN , Shabbir Hussain I. Merchant , Patrick McGurrin , Mark Hallett

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Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome

2024 , Brian Walitt , Komudi Singh , Samuel R. LaMunion , Mark Hallett , Steve Jacobson , Kong Chen , Yoshimi Enose-Akahata , Richard Apps , Jennifer J. Barb , Patrick Bedard , Robert J. Brychta , Ashura Williams Buckley , Peter D. Burbelo , Brice Calco , Brianna Cathay , Li Chen , Snigdha Chigurupati , Jinguo Chen , Foo Cheung , Lisa M. K. Chin , Benjamin W. Coleman , Amber B. Courville , Madeleine S. Deming , Bart Drinkard , Li Rebekah Feng , Luigi Ferrucci , Scott A. Gabel , Angelique Gavin , David S. Goldstein , Shahin Hassanzadeh , Sean C. Horan , Silvina G. Horovitz , Kory R. Johnson , Anita Jones Govan , Kristine M. Knutson , Joy D. Kreskow , Mark Levin , Jonathan J. Lyons , Nicholas Madian , Nasir Malik , Andrew L. Mammen , John A. McCulloch , Patrick M. McGurrin , Joshua D. Milner , Ruin Moaddel , Geoffrey A. Mueller , Amrita Mukherjee , Sandra Muñoz-Braceras , Gina Norato , Katherine Pak , Iago Pinal-Fernandez , Traian Popa , Lauren B. Reoma , Michael N. Sack , Farinaz Safavi , Leorey N. Saligan , Brian A. Sellers , Stephen Sinclair , Bryan Smith , Joseph Snow , Stacey Solin , Barbara J. Stussman , Giorgio Trinchieri , Sara A. Turner , C. Stephenie Vetter , VIAL UNDURRAGA, FELIPE AGUSTIN , Carlotta Vizioli , Ashley Williams , Shanna B. Yang , Avindra Nath

AbstractPost-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning. Immune profiling suggested chronic antigenic stimulation with increase in naïve and decrease in switched memory B-cells. Alterations in gene expression profiles of peripheral blood mononuclear cells and metabolic pathways were consistent with cellular phenotypic studies and demonstrated differences according to sex. Together these clinical abnormalities and biomarker differences provide unique insight into the underlying pathophysiology of PI-ME/CFS, which may guide future intervention.

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Clinical features of 63 patients with ataxia

2018 , Paula Saffie Awad , VIAL UNDURRAGA, FELIPE AGUSTIN , Pedro Chaná-Cuevas

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BacAv, a new free online platform for clinical back-averaging

2020 , VIAL UNDURRAGA, FELIPE AGUSTIN , Sanaz Attaripour , Patrick McGurrin , Mark Hallett

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How to do an electrophysiological study of tremor

2019 , Felipe Vial , Panagiotis Kassavetis , Shabbir Merchant , Dietrich Haubenberger , Mark Hallett

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Physiology of Tremor Reduction by Putting the Hands Together in Essential Tremor

2021 , Patrick McGurrin , VIAL UNDURRAGA, FELIPE AGUSTIN , Thomas Osterholt , Gina Norato , Imran Khan , Dietrich Haubenberger , Debra Ehrlich , Mark Hallett

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Measuring conduction velocity distributions in peripheral nerves using neurophysiological techniques

2020 , Zhen Ni , VIAL UNDURRAGA, FELIPE AGUSTIN , Alexandru V. Avram , Giorgio Leodori , Sinisa Pajevic , Peter J. Basser , Mark Hallett

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Identifying transcranial magnetic stimulation induced EEG signatures of different neuronal elements in primary motor cortex

2022 , Zhen Ni , Sinisa Pajevic , Li Chen , Giorgio Leodori , VIAL UNDURRAGA, FELIPE AGUSTIN , Alexandru V. Avram , Yong Zhang , Patrick McGurrin , Leonardo G. Cohen , Peter J. Basser , Mark Hallett

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A novel exaggerated “spino-bulbo-spinal like” reflex of lower brainstem origin

2019 , Shabbir Hussain Merchant , VIAL UNDURRAGA, FELIPE AGUSTIN , Giorgio Leodori , Stanley Fahn , Seth L. Pullman , Mark Hallett

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Re‐emergent Tremor in Parkinson's Disease: The Role of the Motor Cortex

2020 , Giorgio Leodori , Daniele Belvisi , Maria I. De Bartolo , Andrea Fabbrini , Matteo Costanzo , VIAL UNDURRAGA, FELIPE AGUSTIN , Antonella Conte , Mark Hallett , Alfredo Berardelli