REYES ARAMBURU, EDISON PABLO
Thumbnail Image
Preferred name
REYES ARAMBURU, EDISON PABLO
Main Affiliation
Email
preyes@udd.cl
ORCID
Scopus Author ID
35870354700

Research Output

2024 2024 2023 2023 2022 2022 2021 2021 2020 2020 2019 2019 2018 2018 2017 2017 2016 2016 2015 2015 0.0 0.0 0.5 0.5 1.0 1.0 1.5 1.5 2.0 2.0 2.5 2.5 3.0 3.0 3.5 3.5 4.0 4.0

Filters

1
17
Reset filters

Settings
Now showing 1 - 10 of 17
No Thumbnail Available
Publication

Comparison of achievement in anamnesis skills in on-site and online formative Objective Structured Clinical Exam

2023 , Mariana Jadue , Pilar Munitiz , Luz-María Torres , Marcelo Blacutt , Soledad Armijo-Rivera , REYES ARAMBURU, EDISON PABLO

Introduction: anamnesis is an initial step of the clinical reasoning process, which is taught throughout interviews to real or simulated patients. Its evaluation through OSCEs is widely disseminated, and in the context of a pandemic, the OSCE was adapted to be administered online. Objective: to compare the levels of achievement in anamnesis skills of two cohorts of medical students in formative OSCEs of semiology in on-site and online modality. Methods: using a blueprint established in 2017 and implemented for three years, competencies were identified that could be trained and evaluated online in third-year medical students. Telesimulations were performed with role play for anamnesis ability. Guided by a tutor, each student participated in 10 telesimulated anamnesis with peer roleplay and one anamnesis with a simulated pacientent. All of it in groups of 6 students. A formative TeleOSCE was implemented, evaluating the same skills of the year 2019 in a face-to-face training instance. In 2019 and 2020, 92 and 91 students participated respectively. The students' performance was compared in three identical scenarios. Results: at the cough, acute diarrhea, and knee pain screening scenarios, students in the 2020 cohort performed better than those in the 2019 cohort (p<0,001). Conclusions: for the development of anamnesis skill in third-year medical students, telesimulation-based teaching allows students to demonstrate adequate performance on a practical assessment administered online via TeleOSCE.

View
No Thumbnail Available
Publication

Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A machine learning approach

2020 , M. Belen Bachli , Lucas Sedeño , Jeremi K. Ochab , Olivier Piguet , Fiona Kumfor , Pablo Reyes , Teresa Torralva , María Roca , Juan Felipe Cardona , Cecilia Gonzalez Campo , Eduar Herrera , Andrea Slachevsky , Diana Matallana , Facundo Manes , Adolfo M. García , Agustín Ibáñez , Dante R. Chialvo

View
No Thumbnail Available
Publication

Prevalence Distribution of Chronic Obstructive Pulmonary Disease (COPD) in the City of Osorno (Chile) in 2018, and Its Association with Fine Particulate Matter PM2.5 Air Pollution

2024 , Ricardo Fernández , Romina Peña , Jaime Bravo-Alvarado , Kevin R. Maisey , REYES ARAMBURU, EDISON PABLO , Daniel Ruiz-Plaza De Los Reyes , Rodrigo Márquez-Reyes

Outdoor air pollution and biomass smoke exposure are related to the prevalence of chronic obstructive pulmonary disease (COPD). Since Osorno, Chile, is saturated with fine particulate matter (PM2.5), the aim of this work is to determine the prevalence distribution of COPD patients in the Primary Health Care (PHC) system in the city of Osorno, and its relationship with PM2.5. A cross-sectional descriptive study was carried out on COPD patients enrolled in the six PHC centers (PHCCs) of the city to assess the adjusted prevalence (population over 40 years). Gender- and territory-associated odds ratios (ORs) were also determined. In addition, an urban analysis of the distribution of PM2.5 and an exploratory analysis of the spatial behavior of enrolled COPD patients through featured binning were carried out. In 2018, the city of Osorno had 809 enrolled COPD patients in the PHC system (55.1% female), with a 1.3% age-adjusted prevalence (inhabitants over 40 years old), which was 11.7% after underdiagnosis correction. The COPD patients were mainly between 70 and 79 years old (34.3%). The urban area under the administration of the PHCC Rahue Alto (PHCC-RA) had a higher OR (1.98 [1.73–2.26]) compared to the situation of the city. Also, air pollution (PM2.5) was the highest in the PHCC-RA area, which could account for the observed prevalence. The number of COPD patients in this area is the highest in the commune, which increases the risk of complications derived from the disease and air pollution. Thus, territories with the highest COPD prevalence have the largest OR, which could complicate patients’ condition due to the high levels of outdoor air pollution.

View
No Thumbnail Available
Publication

Mechanical and Antimicrobial Polyethylene Composites with CaO Nanoparticles

2020 , Cristián Silva , Felipe Bobillier , Daniel Canales , Francesca Antonella Sepúlveda , Alejandro Cament , Nicolás Amigo , Lina M. Rivas , María T. Ulloa , REYES ARAMBURU, EDISON PABLO , J. Andrés Ortiz , Tatiana Gómez , Carlos Loyo , Paula A. Zapata

Low-density polyethylene composites containing different sizes of calcium oxide (CaO) nanoparticles were obtained by melt mixing. The CaO nanoparticles were synthesized by either the sol-gel or sonication methods, obtaining two different sizes: ca. 55 nm and 25 nm. These nanoparticles were used either as-synthesized or were modified organically on the surface with oleic acid (Mod-CaO), at concentrations of 3, 5, and 10 wt% in the polymer. The Mod-CaO nanoparticles of 25 nm can act as nucleating agents, increasing the polymer’s crystallinity. The Young’s Modulus increased with the Mod-CaO nanoparticles, rendering higher reinforcement effects with an increase as high as 36%. The reduction in Escherichia coli bacteria in the nanocomposites increased with the amount of CaO nanoparticles, the size reduction, and the surface modification. The highest antimicrobial behavior was found in the composites with a Mod-CaO of 25 nm, presenting a reduction of 99.99%. This strong antimicrobial effect can be associated with the release of the Ca2+ from the composites, as studied for the composite with 10 wt% nanoparticles. The ion release was dependent on the size of the nanoparticles and their surface modification. These findings show that CaO nanoparticles are an excellent alternative as an antimicrobial filler in polymer nanocomposites to be applied for food packaging or medical devices.

View
No Thumbnail Available
Publication

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

2024 , Sebastian Moguilner , Sandra Baez , Hernan Hernandez , Joaquín Migeot , Agustina Legaz , Raul Gonzalez-Gomez , Francesca R. Farina , Pavel Prado , Jhosmary Cuadros , Enzo Tagliazucchi , Florencia Altschuler , Marcelo Adrián Maito , María E. Godoy , Josephine Cruzat , Pedro A. Valdes-Sosa , Francisco Lopera , John Fredy Ochoa-Gómez , Alfredis Gonzalez Hernandez , Jasmin Bonilla-Santos , Rodrigo A. Gonzalez-Montealegre , Renato Anghinah , Luís E. d’Almeida Manfrinati , Sol Fittipaldi , Vicente Medel , Daniela Olivares , Görsev G. Yener , Javier Escudero , Claudio Babiloni , Robert Whelan , Bahar Güntekin , Harun Yırıkoğulları , Hernando Santamaria-Garcia , Alberto Fernández Lucas , David Huepe , Gaetano Di Caterina , Marcio Soto-Añari , Agustina Birba , Agustin Sainz-Ballesteros , Carlos Coronel-Oliveros , Amanuel Yigezu , Eduar Herrera , Daniel Abasolo , Kerry Kilborn , Nicolás Rubido , Ruaridh A. Clark , Ruben Herzog , Deniz Yerlikaya , Kun Hu , Mario A. Parra , Pablo Reyes , Adolfo M. García , Diana L. Matallana , José Alberto Avila-Funes , Andrea Slachevsky , BEHRENS PELLEGRINO, MARIA ISABEL , Nilton Custodio , Juan F. Cardona , Pablo Barttfeld , Ignacio L. Brusco , Martín A. Bruno , Ana L. Sosa Ortiz , Stefanie D. Pina-Escudero , Leonel T. Takada , Elisa Resende , Katherine L. Possin , Maira Okada de Oliveira , Alejandro Lopez-Valdes , Brian Lawlor , Ian H. Robertson , Kenneth S. Kosik , Claudia Duran-Aniotz , Victor Valcour , Jennifer S. Yokoyama , Bruce Miller , Agustin Ibanez

AbstractBrain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex and neurodegeneration) on the brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American and Caribbean countries (LAC) and 8 non-LAC countries). Based on higher-order interactions, we developed a brain-age gap deep learning architecture for functional magnetic resonance imaging (2,953) and electroencephalography (2,353). The datasets comprised healthy controls and individuals with mild cognitive impairment, Alzheimer disease and behavioral variant frontotemporal dementia. LAC models evidenced older brain ages (functional magnetic resonance imaging: mean directional error = 5.60, root mean square error (r.m.s.e.) = 11.91; electroencephalography: mean directional error = 5.34, r.m.s.e. = 9.82) associated with frontoposterior networks compared with non-LAC models. Structural socioeconomic inequality, pollution and health disparities were influential predictors of increased brain-age gaps, especially in LAC (R² = 0.37, F² = 0.59, r.m.s.e. = 6.9). An ascending brain-age gap from healthy controls to mild cognitive impairment to Alzheimer disease was found. In LAC, we observed larger brain-age gaps in females in control and Alzheimer disease groups compared with the respective males. The results were not explained by variations in signal quality, demographics or acquisition methods. These findings provide a quantitative framework capturing the diversity of accelerated brain aging.

View
No Thumbnail Available
Publication

Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide

2015 , Gino Nardocci , Aldo Martin , Sebastián Abarzúa , Jorge Rodríguez , Felipe Simon , REYES ARAMBURU, EDISON PABLO , Claudio Acuña-Castillo , Cristina Navarro , Paula P. Cortes , Ricardo Fernández

View
No Thumbnail Available
Publication

Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer's Disease

2017 , SLACHEVSKY CHONCHOL, ANDREA MARÍA , Leonardo Guzmán-Martínez , Carolina Delgado , Pablo Reyes , Gonzalo A. Farías , Carlos Muñoz-Neira , Eduardo Bravo , Mauricio Farías , Patricia Flores , Cristian Garrido , James T. Becker , Oscar L. López , Ricardo B. Maccioni , Paulo Caramelli

View
No Thumbnail Available
Publication

LPS-Induced c-Fos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats Are Suppressed by Bilateral Carotid Chemodenervation

2012 , REYES ARAMBURU, EDISON PABLO , Sebastián Abarzúa , Aldo Martin , Jorge Rodríguez , Paula P. Cortés , Ricardo Fernández

View
No Thumbnail Available
Publication

Educational disparities in brain health and dementia across Latin America and the United States

2024 , Raul Gonzalez‐Gomez , Agustina Legaz , Sebastián Moguilner , Josephine Cruzat , Hernán Hernández , Sandra Baez , Rafael Cocchi , Carlos Coronel‐Olivero , Vicente Medel , Enzo Tagliazuchi , Joaquín Migeot , Carolina Ochoa‐Rosales , Marcelo Adrián Maito , Pablo Reyes , Hernando Santamaria Garcia , Maria E. Godoy , Shireen Javandel , Adolfo M. García , Diana L. Matallana , José Alberto Avila‐Funes , María I. Behrens , SLACHEVSKY CHONCHOL, ANDREA MARÍA , Nilton Custodio , Juan F. Cardona , Ignacio L. Brusco , Martín A. Bruno , Ana L. Sosa Ortiz , Stefanie D. Pina‐Escudero , Leonel T. Takada , Elisa de Paula França Resende , Victor Valcour , Katherine L. Possin , Maira Okada de Oliveira , Francisco Lopera , Brian Lawlor , Kun Hu , Bruce Miller , Jennifer S. Yokoyama , Cecilia Gonzalez Campo , Agustin Ibañez

AbstractBACKGROUNDEducation influences brain health and dementia. However, its impact across regions, specifically Latin America (LA) and the United States (US), is unknown.METHODSA total of 1412 participants comprising controls, patients with Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD) from LA and the US were included. We studied the association of education with brain volume and functional connectivity while controlling for imaging quality and variability, age, sex, total intracranial volume (TIV), and recording type.RESULTSEducation influenced brain measures, explaining 24%–98% of the geographical differences. The educational disparities between LA and the US were associated with gray matter volume and connectivity variations, especially in LA and AD patients. Education emerged as a critical factor in classifying aging and dementia across regions.DISCUSSIONThe results underscore the impact of education on brain structure and function in LA, highlighting the importance of incorporating educational factors into diagnosing, care, and prevention, and emphasizing the need for global diversity in research.Highlights Lower education was linked to reduced brain volume and connectivity in healthy controls (HCs), Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD). Latin American cohorts have lower educational levels compared to the those in the United States. Educational disparities majorly drive brain health differences between regions. Educational differences were significant in both conditions, but more in AD than FTLD. Education stands as a critical factor in classifying aging and dementia across regions.

View
No Thumbnail Available
Publication

Are there interactions between acetylcholine- and ATP-induced responses at the level of a visceral sensory ganglion?

2006-08-30 , REYES ARAMBURU, EDISON PABLO , Alcayaga, Julio , Zapata, Patricio

We investigate possible interactions between acetylcholine (ACh)- and adenosine 5′-triphosphate (ATP)-induced responses of petrosal ganglion, where the perikarya of most sensory neurons of the glossopharyngeal nerve are located. Experiments were performed on petrosal ganglia excised from pentobarbitone-anesthetized cats, desheathed and perfused in vitro. Separate applications of ACh and ATP to the exposed surface of the ganglion induced bursts of antidromic potentials recorded from the carotid (sinus) nerve branch of the glossopharyngeal nerve, which frequencies were dependent on the dose of the applied agonists. The simultaneous application of previously determined ED50s of ACh and ATP provoked responses corresponding closely to the simple addition of the responses elicited by the separate application of each agent. Responses usually subsided within 1 min of stimuli application but were followed by periods of refractoriness to subsequent application of the same agent. After determining the timing for recovering from desensitization to the ED50s of ACh and ATP applied separately, ACh was applied while the preparation had been desensitized to ATP and then ATP was applied during desensitization to ACh, but responses obtained were similar to control responses induced by each agent separately. In summary, ACh- and ATP-induced responses of petrosal ganglion neurons are simply additive, followed by a few minute lasting desensitization, but cross-desensitization was not observed. Thus, ACh and ATP seem to operate through independent receptors, activating separate ionic channels, whose coincident currents do not interfere each other. © 2006 Elsevier B.V. All rights reserved.

View