CARVAJAL HAUSDORF, DANIEL EDUARDO
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CARVAJAL HAUSDORF, DANIEL EDUARDO
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dcarvajal@udd.cl
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56274228900

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2023 2023 2022 2022 2021 2021 2020 2020 2019 2019 2018 2018 2017 2017 2016 2016 2015 2015 2014 2014 0.0 0.0 1.0 1.0 2.0 2.0 3.0 3.0 4.0 4.0 5.0 5.0

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Expresión y amplificación del gen HER2 en el cáncer gástrico avanzado

2013 , Iván Roa , Jeannie Slater , Daniel Carvajal , Kurt Schalper , Gonzalo de Toro , Raúl Ares , Anakaren Game , Jorge León , Xabier de Aretxabala

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Dataset - Identification of Circulating lncRNAs Associated with Gallbladder Cancer Risk by Tissue-Based Preselection, Cis-eQTL Validation, and Analysis of Association with Genotype-Based Expression

2021 , CARVAJAL HAUSDORF, DANIEL EDUARDO

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Macrodissection prior to closed system RT-qPCR is not necessary for estrogen receptor and HER2 concordance with IHC/FISH in breast cancer

2018 , Swati Gupta , Navin R. Mani , CARVAJAL HAUSDORF, DANIEL EDUARDO , Veerle Bossuyt , Kenneth Ho , Jodi Weidler , Wendy Wong , Brian Rhees , Michael Bates , David L. Rimm

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Dataset - BioStudies ArrayExpress - Functional Genomics Data

2021 , CARVAJAL HAUSDORF, DANIEL EDUARDO

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Objective measurement and clinical significance of IDO1 protein in hormone receptor-positive breast cancer

2017 , CARVAJAL HAUSDORF, DANIEL EDUARDO , Nikita Mani , Vamsidhar Velcheti , Kurt A. Schalper , David L. Rimm

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NTRK genomic alterations in Latin-American cancer patients.

2021 , CARVAJAL HAUSDORF, DANIEL EDUARDO , Claudio Salas , Katherine Marcelain , Francisco Perez , Evelin Feliu , Kurt Schalper , Solange Rivas , ARMISEN YAÑEZ, RICARDO AMADO

e15088 Background: The neurotrophic receptor tyrosine kinase genes NTRK1-3 encode the tropomyosin receptor kinase proteins TRKA, TRKB, and TRKC, respectively. TRK fusions lead to overexpression of the chimeric protein, resulting in constitutively active, ligand-independent downstream signaling. NTRKs act as oncogenes, they can be targeted, and it is estimated that they are present in up to 0.3% of tumors. The incidence of actionable alterations in these genes is currently unknown in Latin-American patients. We investigated the presence of NTRK1-3 mutations/rearrangements in 3 independent patient series from several tertiary hospitals from Chile, Brazil and Peru. Methods: 1795 FFPE tumor samples from multiple institutions divided in 3 series were analyzed using 2 NGS panels: Oncomine Focus Assay (OFA; 52 genes) and Oncomine Comprehensive Assay (OCA; 161 genes. Data on NTRK1-3 SNVs, indels, CNVs and fusions was obtained. Bioinformatic workflows were used to study the biologic significance of these alterations. Results: Using OCA (series 1-2), 31 somatic variants were found in gastric, CRC, gallbladder, lung and pancreatic cases out of 300 patients. From these, 13 were located in the tyrosine kinase domain. Using OFA, no NTRK alteration were detected (series 3, 1495 NSCLC cases). Conclusions: NTRK alterations are rare events in Latin-American cancer patients. In 3 series including 1,795 patients, 31 somatic variants were detected. No NTRK fusions or CNVs were identified. The presence of NTRK mutations in the tyrosine kinase domain warrants further research into their potential to benefit from FDA/EMA-approved targeted therapies. [Table: see text]

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Association of B7-H4, PD-L1, and tumor infiltrating lymphocytes with outcomes in breast cancer

2018 , Mehmet Altan , Kelley M. Kidwell , Vasiliki Pelekanou , CARVAJAL HAUSDORF, DANIEL EDUARDO , Kurt A. Schalper , Maria I. Toki , Dafydd G. Thomas , Michael S. Sabel , Daniel F. Hayes , David L. Rimm

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Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry

2019 , CARVAJAL HAUSDORF, DANIEL EDUARDO , Jonathan Patsenker , Kelly P. Stanton , Franz Villarroel-Espindola , Amanda Esch , Ruth R. Montgomery , Amanda Psyrri , Konstantine T. Kalogeras , Vassiliki Kotoula , George Foutzilas , Kurt A. Schalper , Yuval Kluger , David L. Rimm

Abstract Purpose: Imaging mass cytometry (IMC) uses metal-conjugated antibodies to provide multidimensional, objective measurement of protein targets. We used this high-throughput platform to perform an 18-plex assessment of HER2 ICD/ECD, cytotoxic T-cell infiltration and other structural and signaling proteins in a cohort of patients treated with trastuzumab to discover associations with trastuzumab benefit. Experimental Design: An antibody panel for detection of 18 targets (pan-cytokeratin, HER2 ICD, HER2 ECD, CD8, vimentin, cytokeratin 7, β-catenin, HER3, MET, EGFR, ERK 1–2, MEK 1–2, PTEN, PI3K p110 α, Akt, mTOR, Ki67, and Histone H3) was used with a selection of trastuzumab-treated patients from the Hellenic Cooperative Oncology Group 10/05 trial (n = 180), and identified a case–control series. Results: Patients that recurred after adjuvant treatment with trastuzumab trended toward a decreased fraction of HER2 ECD pixels over threshold compared with cases without recurrence (P = 0.057). After exclusion of the lowest HER2 expressers, 5-year recurrence events were associated with reduced total extracellular domain (ECD)/intracellular domain (ICD) ratio intensity in tumor (P = 0.044). These observations are consistent with our previous work using quantitative immunofluorescence, but represent the proof on identical cell content. We also describe the association of the ECD of HER2 with CD8 T-cell infiltration on the same slide. Conclusions: The proximity of CD8 cells as a function of the expression of the ECD of HER2 provides further evidence for the role of the immune system in the mechanism of action of trastuzumab.

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"Real world" and objective analysis of PD-L1 immunohistochemistry in transbronchial and EBUS-TBNA samples from NSCLC patients from a Chilean tertiary hospital

2019 , Yumay Pires , Viviana Ahumada , Marcela Schultz , Macarena Rodriguez Vial , CARVAJAL HAUSDORF, DANIEL EDUARDO

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1725P Metastasis-resident bacteria in advanced hormone receptor-positive breast cancer are related to primary tumor microbiota and show distinct composition

2022 , C. Araya , S. Contreras-Riquelme , B. Mino , F.J. Perez , A.J. Martin , CARVAJAL HAUSDORF, DANIEL EDUARDO

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