BRUNSER RABOVICH, ALEJANDRO MICHEL
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BRUNSER RABOVICH, ALEJANDRO MICHEL
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Email
abrunser@alemana.cl
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Scopus Author ID
26644722200

Research Output

2024 2024 2023 2023 2022 2022 2021 2021 2020 2020 2019 2019 2018 2018 2017 2017 2016 2016 2015 2015 0 0 2 2 4 4 6 6 8 8 10 10 12 12 14 14 16 16
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Validation of the transcranial Doppler rescue criteria for mechanical thrombectomy

2024 , Adnan Khan , Maher Saqqur , Ashfaq Shuaib , Khurshid Khan , Vijay K. Sharma , BRUNSER RABOVICH, ALEJANDRO MICHEL , Jürgen Eggers , Robert Mikulik , Aristeidis H. Katsanos , Theodore N. Sergentanis , Konstantinos Vadikolias , Marta Rubiera , Reza Bavarsad Shahripour , Huy Thang Nguyen , Patricia Martínez‐Sánchez , Apostolos Safouris , Ioannis Heliopoulos , Abdul Salam , Carol Derksen , Konstantinos Voumvourakis , Theodora Psaltopoulou , Anne W. Alexandrov , Andrei V. Alexandrov , Georgios Tsivgoulis

AbstractBackground and PurposeTranscranial Doppler (TCD) identifies acute stroke patients with arterial occlusion where treatment may not effectively open the blocked vessel. This study aimed to examine the clinical utility and prognostic value of TCD flow findings in patients enrolled in a multicenter prospective study (CLOTBUST‐PRO).MethodsPatients enrolled with intracranial occlusion on computed tomography angiography (CTA) who underwent urgent TCD evaluation before intravenous thrombolysis was included in this analysis. TCD findings were assessed using the mean flow velocity (MFV) ratio, comparing the reciprocal ratios of the middle cerebral artery (MCA) depths bilaterally (affected MCA‐to‐contralateral MCA MFV [aMCA/cMCA MFV ratio]).ResultsA total of 222 patients with intracranial occlusion on CTA were included in the study (mean age: 64 ± 14 years, 62% men). Eighty‐eight patients had M1 MCA occlusions; baseline mean National Institutes of Health Stroke Scale (NIHSS) score was 16, and a 24‐hour mean NIHSS score was 10 points. An aMCA/cMCA MFV ratio of <.6 had a sensitivity of 99%, specificity of 16%, positive predictive value (PV) of 60%, and negative PV of 94% for identifying large vessel occlusion (LVO) including M1 MCA, terminal internal carotid artery, or tandem ICA/MCA. Thrombolysis in Brain Ischemia scale, with (grade ≥1) compared to without flow (grade 0), showed a sensitivity of 17.1%, specificity of 86.9%, positive PV of 62%, and negative PV of 46% for identifying LVO.ConclusionsTCD is a valuable modality for evaluating arterial circulation in acute ischemic stroke patients, demonstrating significant potential as a screening tool for intravenous/intra‐arterial lysis protocols.

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Seasonal trend of cervical artery dissection in a Chilean cohort

2019 , RECULE GONZALEZ, FRANCISCA , MAZZON AGURTO, ENRICO , DIAZ TAPIA, VIOLETA DEL CARMEN , Rocha, Diego , BRUNSER RABOVICH, ALEJANDRO MICHEL , De La Barra, Camila , Zuniga, Paulo , Dominga Garcia, Maria , Gabriel Cavada , MUÑOZ VENTURELLI, PAULA ANDREA , Zeballos, Shirley , Charaf, Yusef

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EFFECT OF AGE ON ARTERIAL RECANALIZATION AND OUTCOME IN THROMBOLYSED ACUTE ISCHEMIC STROKE PATIENTS

2020 , BRUNSER RABOVICH, ALEJANDRO MICHEL , Sharma, A. , Tsivgoulis, G. , Eggers, J. , Mikulik, R. , Katsanos, A. H. , Vadikolias, K. , Rubiera, M. , Shahripour, R. , Thang-Nguyen, H. , Martinez-Sanchez, P. , Hatzitolios, A. , Shuaib, A. , Voumvourakis, K. , Derksen, C. , Psaltopoulou, T. , Alexandrov, A. W. , Alexandrov, A. , Saqqur, M

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Rectifying the misconceptions about current best management of asymptomatic carotid stenosis is not about revising history

2020 , Anne L. Abbott , BRUNSER, ALEJANDRO , Athanasios Giannoukas , Robert E. Harbaugh , Timothy Kleinig , Simona Lattanzi , Holger Poppert , Tatjana Rundek , Saeid Shahidi , Mauro Silvestrini , Raffi Topakian

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IMPACT OF ETHNICITY ON ARTERIAL RECANALIZATION IN ACUTE ISCHEMIC STROKE

2020 , BRUNSER RABOVICH, ALEJANDRO MICHEL , Sharma, A. , Saqqur, M. , Tsivgoulis, G. , Eggers, J. , Mikulik, R. , Katsanos, A. H. , Vadikolias, K. , Rubiera, M. , Shahripour, R. , Thang-Nguyen, H. , Martinez-Sanchez, P. , Hatzitolios, A. , Shuaib, A. , Derksen, C. , Voumvourakis, K. , Psaltopoulou, T. , Alexandrov, A. W. , Alexandrov, A. , Sharma, V.

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Cervical Artery Dissection in Postpartum Women after Cesarean and Vaginal Delivery

2022 , Francisca Urrutia , MAZZON AGURTO, ENRICO , BRUNSER, ALEJANDRO , DIAZ TAPIA, VIOLETA DEL CARMEN , CALDERON GIADROSIC, JUAN FRANCISCO , STECHER GUZMAN, XIMENA PATRICIA , Tomas Bernstein , Paulo Zuñiga , SCHILLING REDLICH, ANDREA INGRID , MUÑOZ VENTURELLI, PAULA

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In-Hospital Acute Ischemic Stroke is Associated with Worse Outcome: Experience of a Single Center in Santiago Chile

2021 , BRUNSER RABOVICH, ALEJANDRO MICHEL , Patricia Araneda , NAVIA GONZALEZ, VICTOR HUGO , MAZZON AGURTO, ENRICO , Gabriel Cavada , MUÑOZ VENTURELLI, PAULA ANDREA , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , LAVADOS GERMAIN, PABLO MANUEL

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Timing of Tissue-plasminogen-activator Induced Recanalization and Functional Recovery in Acute Ischemic Stroke.

2019 , BRUNSER RABOVICH, ALEJANDRO MICHEL , Georgios Tsivgoulis , Maher Saqqur , Vijay Sharma , Eggers, Jurgen , Robert Mikulik

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Statistical analysis plan of the head position in acute ischemic stroke trial pilot (HEADPOST pilot)

2017 , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , Hisatomi Arima , Craig S Anderson , BRUNSER, ALEJANDRO , MUÑOZ VENTURELLI, PAULA ANDREA , Laurent Billot , LAVADOS GERMAIN, PABLO MANUEL

Background The HEADPOST Pilot is a proof-of-concept, open, prospective, multicenter, international, cluster randomized, phase IIb controlled trial, with masked outcome assessment. The trial will test if lying flat head position initiated in patients within 12 h of onset of acute ischemic stroke involving the anterior circulation increases cerebral blood flow in the middle cerebral arteries, as measured by transcranial Doppler. The study will also assess the safety and feasibility of patients lying flat for ≥24 h. The trial was conducted in centers in three countries, with ability to perform early transcranial Doppler. A feature of this trial was that patients were randomized to a certain position according to the month of admission to hospital. Objective To outline in detail the predetermined statistical analysis plan for HEADPOST Pilot study. Methods All data collected by participating researchers will be reviewed and formally assessed. Information pertaining to the baseline characteristics of patients, their process of care, and the delivery of treatments will be classified, and for each item, appropriate descriptive statistical analyses are planned with comparisons made between randomized groups. For the outcomes, statistical comparisons to be made between groups are planned and described. Results This statistical analysis plan was developed for the analysis of the results of the HEADPOST Pilot study to be transparent, available, verifiable, and predetermined before data lock. Conclusions We have developed a statistical analysis plan for the HEADPOST Pilot study which is to be followed to avoid analysis bias arising from prior knowledge of the study findings. Trial registration The study is registered under HEADPOST-Pilot, ClinicalTrials.gov Identifier NCT01706094.

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Validity of the NIHSS in predicting arterial occlusion in cerebral infarction is time-dependent

2010 , V. V. Olavarria , DELGADO BECERRA, OROZIMBA IRIS , HOPPE WIEGERING, ARNOLD JOHANNES GOTTLIEB , BRUNSER, ALEJANDRO , D. Carcamo , DIAZ TAPIA, VIOLETA DEL CARMEN , LAVADOS GERMAIN, PABLO MANUEL

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