RADA GIACAMAN, GABRIEL ALEJANDRO

Preferred name

Main Affiliation

Facultad de Medicina Clínica Alemana Universidad del Desarrollo

ORCID

0000-0003-2435-0710

Scopus Author ID

24773855100

Goggle Scholar

https://scholar.google.com/citations?hl=es&user=m5X3w4sAAAAJ

Now showing 1 - 8 of 8

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EFFECTIVENESS AND SAFETY OF THE TETRAVALENT TAK-003 DENGUE VACCINE: A SYSTEMATIC REVIEW
(2024)
Ramos-rojas José
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Bengolea, Agustin
;
Scigliano, Clara
;
Rada, Gabriel
;
Catalano Hugo N.
1
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Saudi Guideline for Mechanical Ventilation in Adults – Executive Summary
(Ovid Technologies (Wolters Kluwer Health), 2026-02)
Yaseen M. Arabi
;
Zohair Al Aseri
;
RADA GIACAMAN, GABRIEL ALEJANDRO
;
Ahmed A. Abdulmomen
;
Farhan Alenezi
<jats:title>Abstract</jats:title> <jats:p>The Saudi Guideline for Mechanical Ventilation in Adults presents evidence-based recommendations for the care of adults requiring invasive mechanical ventilation. Fourteen priority clinical questions address ventilatory strategies for acute respiratory distress syndrome (ARDS), adjunctive and rescue therapies, sedation and weaning practices, airway management, and supportive ICU care. Strong recommendations support low–tidal-volume ventilation and higher positive end-expiratory pressure in ARDS, as well as head-of-bed elevation to prevent ventilator-associated pneumonia. Conditional recommendations include prone positioning, venovenous extracorporeal membrane oxygenation in selected severe ARDS patients, daily sedation interruption, protocolized spontaneous breathing trials, and early tracheostomy. For several interventions, evidence remains insufficient to support definitive recommendations. This guideline aims to standardize practice and improve outcomes across Saudi intensive care units.</jats:p>
1
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Definition of Uveitis Refractory to Treatment: A Systematic Review in the Absence of a Consensus
(2020)
Rodrigo A. Valenzuela
;
Iván Flores
;
Myriam Pujol
;
Carolina Llanos
;
Ester Carreño
3Scopus© Citations 10
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Efectividad y seguridad de la vacuna recombinante para herpes zóster en diferentes poblaciones: revisión sistemática y metaanálisis
(2024-01-01)
Bengolea, Agustín
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Chamorro, Florencia
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Ramos, José T.
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Rada, Gabriel
;
Catalano, Hugo N.
Varicella-zoster virus infections have increased globally, with complications such as postherpetic neuralgia and neurological sequelae. The recombinant vaccine against herpes zoster is proposed as a preventive strategy. This systematic review evaluates its effectiveness and safety in healthy and high-risk populations. A systematic review of randomized controlled trials comparing the effectiveness and safety of the vaccine was conducted. The search was carried out in Epistemonikos. Two researchers independently assessed the eligibility of the studies and the risk of bias was evaluated using the Cochrane Risk of Bias 2 tool. A meta-analysis of homogeneous results was conducted, and the certainty of the evidence was evaluated using GRADE. A minimally contextualized approach was adopted using predetermined thresholds. Nine randomized controlled trials were selected. The vaccine demonstrated a significant reduction in the incidence of herpes zoster in high-risk populations (risk difference of 140 fewer per 1000) with high certainty. However, in healthy populations, the effect was trivial (28 fewer per 1000). No significant differences were observed in postherpetic neuralgia in any of the populations analyzed. Adverse events increased in both populations, though no discrepancies in serious adverse events were noted. In high-risk populations, where the incidence of herpes zoster and its complications is higher, the vaccine demonstrated effectiveness in lowering the incidence of the disease, though not in that of postherpetic neuralgia. Conversely, in healthy populations, the impact of the vaccine was trivial. Individualized and informed recommendations are crucial when considering this vaccine.
Scopus© Citations 2 2
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Saudi Guideline for Mechanical Ventilation in Adults
(Ovid Technologies (Wolters Kluwer Health), 2026-02)
Yaseen M. Arabi
;
Zohair Al Aseri
;
RADA GIACAMAN, GABRIEL ALEJANDRO
;
Ahmed A. Abdulmomen
;
Farhan Alenezi
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background:</jats:title> <jats:p>Mechanical ventilation is a critical intervention for patients with respiratory failure. Recent advancements and quality improvement initiatives in Saudi Arabia have contributed to refining mechanical ventilation practices. This guideline represents the first national evidence-based framework developed through a multidisciplinary approach.</jats:p> </jats:sec> <jats:sec> <jats:title>Objectives:</jats:title> <jats:p>This guideline provides evidence-based recommendations for the management of mechanically ventilated adults in intensive care units in Saudi Arabia, incorporating best practices to improve patient outcomes and standardize care across healthcare institutions.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>The guideline development followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-ADOLOPMENT methodology, an internationally accepted approach for adopting, adapting, and developing guidelines. A multidisciplinary task force, comprising intensivists, pulmonologists, anaesthesiologists, respiratory therapists, and nursing specialists, conducted a systematic review of the literature and contextualized recommendations for local healthcare settings. The guideline addressed 14 prioritized questions.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>The guideline included strong recommendations for using low tidal volume ventilation for patients with ARDS, utilizing higher levels of positive end-expiratory pressure, and employing head-of-bed elevation. The guideline provided conditional recommendations for using veno-venous extracorporeal membrane oxygenation, daily sedation interruption, protocolized spontaneous breathing trials, prone positioning, using an endotracheal tube with subglottic secretion drainage, using light sedation, and early tracheostomy. The guideline also included a conditional recommendation against using nitric oxide and a neutral recommendation regarding recruitment maneuvers and early mobility.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>This guideline serves as a foundational framework for optimizing mechanical ventilation practices in Saudi Arabia. Future research should focus on local implementation strategies, cost-effectiveness analysis, and the impact of guideline adherence on clinical outcomes.</jats:p> </jats:sec>
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EFFECTIVENESS AND SAFETY OF THE TETRAVALENT TAK-003 DENGUE VACCINE: A SYSTEMATIC REVIEW
(2024-07-01)
Bengolea, Agustín
;
Scigliano, Clara
;
Ramos-Rojas, Jose T.
;
Rada, Gabriel
;
Catalano, Hugo N.
In Argentina, the dengue virus has experienced an increase in recent years. This study aims to conduct a systematic review to evaluate the effectiveness and safety of the TAK-003 tetravalent dengue vaccine in this context. A systematic review of randomized controlled trials comparing the effectiveness and safety of the vaccine with placebo in the general population was conducted. The search was carried out in Epistemonikos, and two researchers independently assessed the studies. Risk of bias was evaluated using the Cochrane Rob 2 tool. A meta-analysis of the results was performed, and the certainty of evidence was assessed using the GRADE methodology. We concluded, with high certainty of evidence, that the tetravalent dengue vaccine reduces severe infections (RR 0.17, 95% CI 0.12 to 0.24) and infections by the dengue virus (RR 0.40, 95% CI 0.36 to 0.45) in a population ≤17 years. The vaccine may not increase the risk of serious adverse events, although it is important to note the low certainty of evidence (RR 1.04, 95% CI: 0.69-1.55). The use of the tetravalent dengue vaccine decreases the risk of severe and non-severe dengue infections in this population. However, there is low certainty of evidence regarding the vaccine’s safety. The decision to vaccinate should consider the magnitude of benefits relative to the risk of infection.
3Scopus© Citations 4
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Including nonrandomized evidence in living systematic reviews: lessons learned from the COVID-NMA initiative
(Elsevier BV, 2026-02)
Hillary Bonnet
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Julian P.T. Higgins
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Anna Chaimani
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Theodoros Evrenoglou
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Lina Ghosn
2
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Living evidence syntheses for long COVID therapeutics: combining rigorous protocols to build efficiency while maintaining rigour
(Springer Science and Business Media LLC, 2026-04-02)
Tiffany Atkins
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Paul Glasziou
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Samantha Chakraborty
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Tari Turner
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RADA GIACAMAN, GABRIEL ALEJANDRO
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Given the rapidly changing evidence, the creation and maintenance of a living systematic review database of therapeutics for long COVID is an ideal and necessary approach considering the rapidly changing evidence that continues to be identified. This paper describes methods and results of a collaboration between three teams who produced a living literature review on long COVID therapeutics—Australian Living Evidence Collaboration (ALEC), Bond University, and Epistemonikos COVID-19 L.OVE (Living Overview of Evidence) database.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>We took a collaborative and iterative approach to analyse the commonalities and differences between each project and develop an agreed comprehensive, collective approach. A plan for ongoing (monthly) updates and dissemination was built.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Despite minor differences, there was also a clear alignment of goals between the three teams. Differences in search strategy, search methods and screening criteria were identified, investigated, and resolved. A comparison of overlaps helped establish a common collaborative approach. A combined library of 218 randomised controlled trials and 56 systematic reviews was created which led to the optimised search strategy. The combined 218 RCT library covered 20 different treatment categories of which 14 were pharmacological and 6 were non-pharmacological. Further refinements and collaborations led to a transformed initial database library of 102 randomised controlled trials as of June 2024 before the team commenced monthly updates.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Despite initial differences, a comprehensive search strategy based on the collaboration of the three teams was developed. Ongoing monthly updates were initiated and are now planned for well into the future to make continual and rapid updates to the library of evidence surrounding therapeutics for long COVID. Where global public health is concerned, it is valuable to review and refine processes in the early stages, so that they can be reliable. We recommend open collaboration to achieve the goal of creating accessible, efficient, and reliable evidence syntheses.</jats:p> </jats:sec>
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RADA GIACAMAN, GABRIEL ALEJANDRO

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