CRIS

Permanent URI for this communityhttps://investigadores.udd.cl/handle/123456789/1

Browse

Search Results

Now showing 1 - 10 of 28

Some of the metrics are blocked by your
consent settings
New standardized five-zone lobectomy with structured assessment in robotic surgery: the French lobectomy
(AME Publishing Company, 2025-04)
Gerardo Mordojovich
;
Niek Hugen
;
Benjamin Bottet
;
François Montagne
;
Ilies Bouabdallah
Scopus© Citations 2 1
Some of the metrics are blocked by your
consent settings
Transolecranon fracture dislocation and transolecranon basal coronoid fracture dislocation; results of standardized treatment in a retrospective cohort
(Elsevier BV, 2025-05)
Joaquín De la Paz
;
LECAROS URZUA, JUAN ALBERTO
;
Andres Calvo
;
Antonio Ariztia
;
Cristian Aravena
2
Some of the metrics are blocked by your
consent settings
Laparoscopic cervico-isthmic cerclage: A “Needle-free” approach for managing cervical insufficiency in pregnant and non-pregnant patients
(2024)
Ignacio Miranda-Mendoza
;
Rocío Durán-Cuiza
;
Paz Navarrete-Rey
;
Alvaro Carrasco
;
Bernardita Walker
Some of the metrics are blocked by your
consent settings
Evidence-Based Treatment Algorithm for Freiberg Disease
(2023)
Ichiro Yoshimura
;
Masato Takao
;
WAGNER HITSCHFFELD, EMILIO
;
Sjoerd Stufkens
;
Jari Dahmen
<jats:p> Freiberg disease is a type of osteonecrosis of the metatarsal head that predominantly occurs in young females and adolescents, although it may occur at any age. The pathophysiology is multifactorial and may involve trauma, altered foot biomechanics, systemic disorders, and arterial insufficiency. The most typical location is the second metatarsal head, but Freiberg disease may also occur in other lesser toes. Nonoperative treatment is best applied in the early stage of the disease; if this is ineffective, surgical treatment is recommended. Currently available surgical procedures include debridement, osteotomy, osteochondral grafting, microfracture, interposition arthroplasty, implant arthroplasty, and metatarsal shortening arthroplasty. In this article, we propose a treatment algorithm for Freiberg disease based on the current literature and expert opinion. </jats:p>
Scopus© Citations 9 1
Some of the metrics are blocked by your
consent settings
Amelioration of morphine withdrawal syndrome by systemic and intranasal administration of mesenchymal stem cell‐derived secretome in preclinical models of morphine dependence
(2023)
Mauricio Quezada
;
Carolina Ponce
;
Pablo Berríos‐Cárcamo
;
Daniela Santapau
;
Javiera Gallardo
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Morphine is an opiate commonly used in the treatment of moderate to severe pain. However, prolonged administration can lead to physical dependence and strong withdrawal symptoms upon cessation of morphine use. These symptoms can include anxiety, irritability, increased heart rate, and muscle cramps, which strongly promote morphine use relapse. The morphine‐induced increases in neuroinflammation, brain oxidative stress, and alteration of glutamate levels in the hippocampus and nucleus accumbens have been associated with morphine dependence and a higher severity of withdrawal symptoms. Due to its rich content in potent anti‐inflammatory and antioxidant factors, secretome derived from human mesenchymal stem cells (hMSCs) is proposed as a preclinical therapeutic tool for the treatment of this complex neurological condition associated with neuroinflammation and brain oxidative stress.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Two animal models of morphine dependence were used to evaluate the therapeutic efficacy of hMSC‐derived secretome in reducing morphine withdrawal signs. In the first model, rats were implanted subcutaneously with mini‐pumps which released morphine at a concentration of 10 mg/kg/day for seven days. Three days after pump implantation, animals were treated with a simultaneous intravenous and intranasal administration of hMSC‐derived secretome or vehicle, and withdrawal signs were precipitated on day seven by i.p. naloxone administration. In this model, brain alterations associated with withdrawal were also analyzed before withdrawal precipitation. In the second animal model, rats voluntarily consuming morphine for three weeks were intravenously and intranasally treated with hMSC‐derived secretome or vehicle, and withdrawal signs were induced by morphine deprivation.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In both animal models secretome administration induced a significant reduction of withdrawal signs, as shown by a reduction in a combined withdrawal score. Secretome administration also promoted a reduction in morphine‐induced neuroinflammation in the hippocampus and nucleus accumbens, while no changes were observed in extracellular glutamate levels in the nucleus accumbens.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Data presented from two animal models of morphine dependence suggest that administration of secretome derived from hMSCs reduces the development of opioid withdrawal signs, which correlates with a reduction in neuroinflammation in the hippocampus and nucleus accumbens.</jats:p></jats:sec>
Scopus© Citations 4 1
Some of the metrics are blocked by your
consent settings
A Novel Technique for Medial Patellofemoral Ligament Reconstruction Using Vertical Patellar Tunnels and Use of a Single Implant. Technical Note
(2022)
Diego Edwards
;
Juan Pablo Casas-Cordero
;
Julián Alonso
;
Daniel Cerda
;
Francisco Cornejo
1
Some of the metrics are blocked by your
consent settings
Posterolateral corner knee injuries: a narrative review
(2021)
FIGUEROA BERRIOS, FRANCISCO JAVIER
;
FIGUEROA POBLETE, DAVID HUMBERTO
;
Sven Putnis
;
Rodrigo Guiloff
;
Patricio Caro
<jats:p>Limited knowledge of the anatomy and biomechanics of the posterolateral corner (PLC) of the knee, coupled with poor patient outcomes with non-operative management, resulted in the PLC often being labelled as the ‘dark side’ of the knee. In the last two decades, extensive research has resulted in a better understanding of the anatomy and function of the PLC, and has led to the development of anatomic reconstructions that have resulted in improved patient outcomes. Despite considerable attention in the clinical orthopaedic literature (nearly 400 articles published in the last decade), a standardized algorithm for the diagnosis and treatment of the PLC is still lacking, and much controversy remains. Considering the literature review, there is not a reconstruction technique that clearly prevails over the others. As anatomic, biomechanical, and clinical knowledge of PLC injuries continues to progress, finding the balance between re-creating native anatomy and safely performing PLC reconstruction provides a big challenge. Treatment decisions should be made on a case-by-case basis.</jats:p><jats:p>Cite this article: EFORT Open Rev 2021;6:676-685. DOI: 10.1302/2058-5241.6.200096</jats:p>
16Scopus© Citations 23
Some of the metrics are blocked by your
consent settings
Totally intracorporeal robot-assisted urinary diversion for bladder cancer (part 2). Review and detailed characterization of the existing intracorporeal orthotopic ileal neobladder
(2021)
Hugo Otaola-Arca
;
Kulthe Ramesh Seetharam Bhat
;
Vipul R. Patel
;
Marcio Covas Moschovas
;
Marcelo Orvieto
4Scopus© Citations 16
Some of the metrics are blocked by your
consent settings
Nanoscopic Distal Biceps Repair With Cortical Button and Interference Screw
(2023)
Felipe Reinares
;
Francisca de la Maza
;
Joaquin de la Paz
;
Manuela Angulo
;
Juan Jose Lecaros
3
Some of the metrics are blocked by your
consent settings
Navigation in anterior cruciate ligament reconstruction: State of the art
(2022)
FIGUEROA BERRIOS, FRANCISCO JAVIER
;
FIGUEROA POBLETE, DAVID HUMBERTO
;
Rodrigo Guiloff
;
Sven Putnis
;
Brett Fritsch
Scopus© Citations 17 1

CRIS

Browse

Filters

Settings

Sort By

Results per page

Search Results