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    Women with polycystic ovary syndrome (PCOS): Likelihood of cooccurring neuropsychiatric conditions and the dual hit hypothesis
    (Elsevier BV, 2025-04)
    Juan Pablo Del Río
    ;
    Alexandros Tsompanidis
    ;
    Pablo A. Gaspar
    ;
    Alejandro Maturana-Hurtado
    ;
    Gonzalo M. Rojas-Costa
    Scopus© Citations 7  6
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    Your baby has down syndrome: a reflexive thematic analysis of breaking the news to parents
    (Springer Science and Business Media LLC, 2025-05-06)
    TENORIO DELGADO, MARCELA  
    ;
    Johanna Sagner-Tapia
    ;
    Renata Garibaldi
    ;
    Vaso Totsika
    Scopus© Citations 1  6
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    “Hasta que me embaracé no conocí matrona”: salud sexual y reproductiva de jóvenes mujeres mapuche, Chile
    (FapUNIFESP (SciELO), 2024)
    CARREÑO CALDERON, ALEJANDRA ANGELICA  
    ;
    OBACH KING, ALEXANDRA ALICE  
    ;
    Correa-Matus, Eliana
    <jats:p>Resumen Este estudio pretende explorar la prevención y promoción de salud sexual y reproductiva en jóvenes mapuche de entre 18 y 24 años, indagando en las relaciones que establecen con el sistema de salud biomédico y en los desafíos para la inclusión de la interculturalidad en las prestaciones dirigidas a esta población. Se trata de una investigación cualitativa de estudio de caso. Se aplicaron 32 entrevistas en profundidad a jóvenes mapuche de sectores rurales y urbanos de la región de la Araucanía, Chile. Se identifica la persistencia un abordaje sanitario que carece de herramientas interculturales y de enfoque de derechos sexuales y reproductivos. Las jóvenes reportan falta de acceso a educación sexual tanto por la distancia que establecen con los servicios biomédicos de atención primaria como por las dificultades de hablar de sexualidad con los adultos de sus comunidades. Se concluye que persisten inequidades en el derecho a la salud sexual y reproductiva de jóvenes indígenas, especialmente en mujeres. Es necesario incorporar el enfoque intercultural y de derechos en la formulación de políticas públicas para esta población. Tales intervenciones requieren ser diseñadas e implementadas involucrando tanto a la población joven como a los agentes de salud de sus comunidades de origen.</jats:p>
      3
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    Linoleic and Arachidonic Fatty Acids and their Potential Relationship
    with Inflammation, Pregnancy, and Fetal Development
    (2024)
    Macarena Ortiz
    ;
    Daniela Álvarez
    ;
    Yasna Muñoz
    ;
    Nicolás Crisosto
    ;
    Rodrigo Valenzuela
    <jats:sec> <jats:title>Abstract:</jats:title> <jats:p>A healthy maternal diet must consider an appropriate supply of long-chain polyunsaturated fatty acids (LCPUFAs) precursors to ensure adequate growth and development of the fetus. In this regard, n-6 PUFAs, predominantly linoleic (C18:2 n-6, LA) and arachidonic acid (C20:4 n-6), have a central role in the development of the central nervous system because they are part of the membrane structure and participate in the metabolism and signal transduction of cells. Nevertheless, they can also be transformed into inflammatory metabolites promoting the pathogenesis of cardiovascular diseases, cancer, and autoimmune or inflammatory conditions. In modern westernized societies, there is a high dietary consumption of foods rich in n-6 PUFAs which could have detrimental consequences for the fetus and neonate due to excessive exposure to these fatty acids (FAs).</jats:p> </jats:sec> <jats:sec> <jats:title>Objective:</jats:title> <jats:p>To summarize the evidence of maternal, placental, and fetal alterations that an excessive intake of n-6 polyunsaturated FAs (PUFAs), LA, and AA, could produce during pregnancy.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>A thorough review of the literature regarding the effects of n-6 PUFAs during pregnancy and lactation including in vivo and in vitro models, was carried out using the PubMed database from the National Library of Medicine-National Institutes of Health.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>An elevated intake of n-6 PUFA, specifically LA, during pregnancy influences children's motor, cognitive, and verbal development during infancy and early childhood. Similarly, they could harm the placenta and the development of other fetal organs such as the fat tissue, liver, and cardiovascular system.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>Maternal diet, specifically LA intake, could have significant repercussions on fetal development and long-term consequences in the offspring, including the possibility of future metabolic and mental diseases. It would be necessary to focus on the prevention of these alterations through timely dietary interventions in the target population.</jats:p> </jats:sec>
    Scopus© Citations 6  11
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      6
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    Prenatal presentation of pleuropulmonary blastoma associated to DICER1 syndrome: differential diagnosis of congenital pulmonary malformation
    (2023)
    Valenzuela, Catalina Catán
    ;
    Paula Vargas Innocenti
    ;
    Gutierrez, Aquiles Hachim
    ;
    Pinto, Pablo Jorquera
    ;
    Ramos, Ximena Claverie
      3Scopus© Citations 2
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    Prenatal vs postnatal diagnosis of 22q11.2 deletion syndrome: cardiac and noncardiac outcomes through 1 year of age
    (2023)
    Lindsay R. Freud
    ;
    Stephanie Galloway
    ;
    T. Blaine Crowley
    ;
    Julie Moldenhauer
    ;
    Ann Swillen
      1Scopus© Citations 9
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    Scopus© Citations 11  3
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      29
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    Effects of a High-Fat Diet and Docosahexaenoic Acid during Pregnancy on Fatty Acid Composition in the Fetal Livers of Mice
    (2023)
    Daniela Álvarez
    ;
    Macarena Ortiz
    ;
    Gabriel Valdebenito
    ;
    Nicolás Crisosto
    ;
    Bárbara Echiburú
    <jats:p>A high-fat diet (HFD) during pregnancy promotes fat accumulation and reduces docosahexaenoic acid (DHA) levels in the liver of the offspring at postnatal ages, which can depend on fetal sex. However, the prenatal mechanisms behind these associations are still unclear. Thus, we analyzed if an HFD alters DHA content and the expression of molecules related to fatty acid (FA) metabolism in the fetal liver. Female C57BL/6 mice were fed a control diet or HFD for 4–6 weeks before pregnancy until the gestational day (GD) 17.5. A subgroup of each diet received DHA (100 mg/Kg) orally from GD 6.5 until 16.5. On GD 17.5, maternal livers, placentas, and livers from male and female fetuses were collected for FA profiling with gas-chromatography and gene expression of molecules related to FA metabolism using qPCR. PPAR-α protein expression was evaluated using Western blot. The gene expression of placental FA transporters was also assessed. An HFD increased eicosapentaenoic acid (EPA) and decreased DHA levels and protein expression of PPAR-α in the fetal livers of both sexes. DHA increased the gene expression of Ppara, Cpt1, and Acsl1 in the livers of female fetuses. Therefore, an HFD reduces DHA levels and PPAR-α, a master regulator of gene expression, in the fetal liver. In turn, the livers of female fetuses seem to be more sensitive to DHA action.</jats:p>
    Scopus© Citations 2