Universidad del Desarrollo

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Ínsula y su relación con las crisis epilépticas: Desde la interocepción al concepto de uno mismo.
(SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2024-09)
Claudia Riffo Allende
;
CERIC GARRIDO, FRANCISCO JOSE
3
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Human Anterior Insula Encodes Performance Feedback and Relays Prediction Error to the Medial Prefrontal Cortex
(2020)
BILLEKE BOBADILLA, PABLO ERNESTO
;
Tomas Ossandon
;
Marcela Perrone-Bertolotti
;
Philippe Kahane
;
Julien Bastin
<jats:title>Abstract</jats:title> <jats:p>Adaptive behavior requires the comparison of outcome predictions with actual outcomes (e.g., performance feedback). This process of performance monitoring is computed by a distributed brain network comprising the medial prefrontal cortex (mPFC) and the anterior insular cortex (AIC). Despite being consistently co-activated during different tasks, the precise neuronal computations of each region and their interactions remain elusive. In order to assess the neural mechanism by which the AIC processes performance feedback, we recorded AIC electrophysiological activity in humans. We found that the AIC beta oscillations amplitude is modulated by the probability of performance feedback valence (positive or negative) given the context (task and condition difficulty). Furthermore, the valence of feedback was encoded by delta waves phase-modulating the power of beta oscillations. Finally, connectivity and causal analysis showed that beta oscillations relay feedback information signals to the mPFC. These results reveal that structured oscillatory activity in the anterior insula encodes performance feedback information, thus coordinating brain circuits related to reward-based learning.</jats:p>
5Scopus© Citations 41
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Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration
(2021)
Paula C. Salamone
;
Agustina Legaz
;
Lucas Sedeño
;
Sebastián Moguilner
;
Matías Fraile-Vazquez
7Scopus© Citations 80
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Damage to Broca’s area does not contribute to long-term speech production outcome after stroke
(2021)
GAJARDO VIDAL, ANDREA ELIZABETH
;
Diego L Lorca-Puls
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PLORAS team
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Holly Warner
;
Bawan Pshdary
<jats:title>Abstract</jats:title> <jats:p>Broca’s area in the posterior half of the left inferior frontal gyrus has long been thought to be critical for speech production. The current view is that long-term speech production outcome in patients with Broca’s area damage is best explained by the combination of damage to Broca’s area and neighbouring regions including the underlying white matter, which was also damaged in Paul Broca’s two historic cases. Here, we dissociate the effect of damage to Broca’s area from the effect of damage to surrounding areas by studying long-term speech production outcome in 134 stroke survivors with relatively circumscribed left frontal lobe lesions that spared posterior speech production areas in lateral inferior parietal and superior temporal association cortices. Collectively, these patients had varying degrees of damage to one or more of nine atlas-based grey or white matter regions: Brodmann areas 44 and 45 (together known as Broca’s area), ventral premotor cortex, primary motor cortex, insula, putamen, the anterior segment of the arcuate fasciculus, uncinate fasciculus and frontal aslant tract. Spoken picture description scores from the Comprehensive Aphasia Test were used as the outcome measure. Multiple regression analyses allowed us to tease apart the contribution of other variables influencing speech production abilities such as total lesion volume and time post-stroke. We found that, in our sample of patients with left frontal damage, long-term speech production impairments (lasting beyond 3 months post-stroke) were solely predicted by the degree of damage to white matter, directly above the insula, in the vicinity of the anterior part of the arcuate fasciculus, with no contribution from the degree of damage to Broca’s area (as confirmed with Bayesian statistics). The effect of white matter damage cannot be explained by a disconnection of Broca’s area, because speech production scores were worse after damage to the anterior arcuate fasciculus with relative sparing of Broca’s area than after damage to Broca’s area with relative sparing of the anterior arcuate fasciculus. Our findings provide evidence for three novel conclusions: (i) Broca’s area damage does not contribute to long-term speech production outcome after left frontal lobe strokes; (ii) persistent speech production impairments after damage to the anterior arcuate fasciculus cannot be explained by a disconnection of Broca’s area; and (iii) the prior association between persistent speech production impairments and Broca’s area damage can be explained by co-occurring white matter damage, above the insula, in the vicinity of the anterior part of the arcuate fasciculus.</jats:p>
Scopus© Citations 105 1
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Allostatic-Interoceptive Overload in Frontotemporal Dementia
(2022)
Agustina Birba
;
Hernando Santamaría-García
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Pavel Prado
;
Josefina Cruzat
;
Agustín Sainz Ballesteros
Scopus© Citations 54 1
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Interoceptive Insular Cortex Mediates Both Innate Fear and Contextual Threat Conditioning to Predator Odor
(2020)
Rodríguez, María
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CERIC GARRIDO, FRANCISCO JOSE
;
Paola Murgas
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Bruce Harland
;
Fernando Torrealba
5Scopus© Citations 17
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A role for the interoceptive insular cortex in the consolidation of learned fear
(2016)
José Patricio Casanova
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Carlos Madrid
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Marco Contreras
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Rodríguez, María
;
Mónica Vasquez
3Scopus© Citations 36

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