Universidad del Desarrollo

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SARS-CoV-2 Infection Risk by Vaccine Doses and Prior Infections Over 24 Months: ProHEpiC-19 Longitudinal Study
(JMIR Publications Inc., 2024-11-22)
Pere Torán-Monserrat
;
Noemí Lamonja-Vicente
;
Anna Costa-Garrido
;
Lucía A Carrasco-Ribelles
;
Bibiana Quirant
<jats:title>Abstract</jats:title> <jats:sec sec-type="background"> <jats:title>Background</jats:title> <jats:p>As the vaccination campaign against COVID-19 progresses, it becomes crucial to comprehend the lasting effects of vaccination on safeguarding against new infections or reinfections.</jats:p> </jats:sec> <jats:sec sec-type="objective"> <jats:title>Objective</jats:title> <jats:p>This study aimed to assess the risk of new SARS-CoV-2 infections based on the number of vaccine doses, prior infections, and other clinical characteristics.</jats:p> </jats:sec> <jats:sec sec-type="methods"> <jats:title>Methods</jats:title> <jats:p>We defined a cohort of 800 health care workers in a 24-month study (March 2020 to December 2022) in northern Barcelona to determine new infections by SARS-CoV-2. We used extended Cox models, specifically Andersen-Gill (AG) and Prentice-Williams-Peterson, and we examined the risk of new infections. The AG model incorporated variables such as sex, age, job title, number of chronic conditions, vaccine doses, and prior infections. Additionally, 2 Prentice-Williams-Peterson models were adjusted, one for those individuals with no or 1 infection and another for those with 2 or 3 infections, both with the same covariates as the AG model.</jats:p> </jats:sec> <jats:sec sec-type="results"> <jats:title>Results</jats:title> <jats:p>The 800 participants (n=605, 75.6% women) received 1, 2, 3, and 4 doses of the vaccine. Compared to those who were unvaccinated, the number of vaccine doses significantly reduced (<jats:italic>P</jats:italic><.001) the risk of infection by 66%, 81%, 89%, and 99%, respectively. Unit increase in the number of prior infections reduced the risk of infection by 75% (<jats:italic>P</jats:italic><.001). When separating individuals by number of previous infections, risk was significantly reduced for those with no or 1 infection by 61% (<jats:italic>P</jats:italic>=.02), and by 88%, 93%, and 99% (<jats:italic>P</jats:italic><.001) with 1, 2, 3, or 4 doses, respectively. In contrast, for those with 2 or 3 previous infections, the reduction was only significant with the fourth dose, at 98% (<jats:italic>P</jats:italic><.001). The number of chronic diseases only increased the risk by 28%‐31% (<jats:italic>P</jats:italic><.001) for individuals with 0‐1 previous infections.</jats:p> </jats:sec> <jats:sec sec-type="conclusions"> <jats:title>Conclusions</jats:title> <jats:p>The study suggests that both prior infections and vaccination status significantly contribute to SARS-CoV-2 immunity, supporting vaccine effectiveness in reducing risk of reinfection for up to 24 months after follow-up from the onset of the pandemic. These insights contribute to our understanding of long-term immunity dynamics and inform strategies for mitigating the impact of COVID-19.</jats:p> </jats:sec>
Scopus© Citations 1 2
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Recommendations of the Gastroenterology Branch for situations related to COVID-19 infection in children
(2020)
LUCERO ALVAREZ, YALDA CECILIA
5
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Recommendations for pediatric chronic liver disease and liver transplant during COVID-19
(2020)
Godoy, M
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Zuloaga, N
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Navarro, E
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Soriano, H
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Vizcaya, C
19
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Calidad de vida relacionada con la salud en chilenos de comunas vulnerables
(2023)
Isabel Rada
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Manuel S. Ortiz
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CABIESES VALDES, BALTICA BEATRIZ
1
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Crowding on public transport using smart card data during the COVID-19 pandemic: New methodology and case study in Chile
(2023)
Franco Basso
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Jonathan Frez
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Hugo Hernández
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Víctor Leiva
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Raúl Pezoa
9Scopus© Citations 15
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COVID-19 y ciudad: hacia un modelo integrado de vivienda, microbiología, ambiente y urbanismo
(2021)
Felipe Encinas
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Katia Soto-Liebe
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Carlos Andrés Aguirre Núñez
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Bernardo González
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Waldo Bustamante
A partir de mayo de 2020, la crisis sanitaria global causada por el virus SARS-CoV-2 traslada su epicentro hacia Latinoamérica, con foco en ciudades que presentan altos índices de pobreza, segregación y hacinamiento. Los avances en microbiología posibilitan comprender en profundidad las relaciones entre ciudad, COVID-19 y otros microorganismos, pero falta establecer un marco conceptual que las articule, especialmente en contextos donde las determinantes sociales son tan relevantes. Este artículo tiene como objetivo el proponer una aproximación integrada de microbiología, vivienda, ambiente y urbanismo, a partir de un modelo de interacciones y un análisis empírico para Santiago de Chile. En base a esto, se pudo analizar cómo el proceso de propagación en la ciudad se ve potenciada por vulnerabilidades de índole socio espacial, sanitaria intradomiciliaria y urbana, más una aproximación desde el concepto de pobreza energética. Al mismo tiempo, se pudo comprobar como las variables asociadas a estas vulnerabilidades permitían explicar la tasa de incidencia de casos confirmados por cada 100 000 habitantes a través de las distintas comunas en el área metropolitana de Santiago de Chile. Dentro de éstas, destacan el nivel de hacinamiento de las viviendas, la cantidad de hogares con jefes/as de hogar en trabajo precario y los viajes hacia el distrito central de negocios de la ciudad. Finalmente, se establece la necesidad de proponer una agenda de investigación para este nuevo equipo multidisciplinario de “Microbioma Urbano” en relación con la necesidad de realización de muestreos microbiológicos que permitan mejorar las condiciones de viviendas, barrios y ciudades, aportando en la superación de las vulnerabilidades identificadas en este estudio.
2Scopus© Citations 5
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La dirección comercial en época de pandemia: el impacto del covid-19 en la gestión de ventas
(2021)
Jorge Bullemore-Campbell
;
Eduard Cristóbal-Fransi
Scopus© Citations 17 3
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COVID-19: Abdominal and Pelvic Imaging Findings: A Primer for Radiologists
(2021)
Sofía Palacios
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SCHIAPPACASSE, GIANCARLO
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Rosario Valdes
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Ignacio Maldonado
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Cristian Varela
2Scopus© Citations 3
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Burnout y factores predictores en profesionales de Enfermería chilenos a un año de pandemia por COVID 19
(2023)
Natalia Aguayo Verdugo
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Rocío Zúñiga Tapia
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SÁNCHEZ OÑATE, ALEJANDRO ANTONIO
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Claudia Barría Sandoval
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Pía Bustamante Barahona
Scopus© Citations 2 11
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COVID 19 y embarazo en Chile: Informe preliminar del estudio multicéntrico GESTACOVID
(2020)
Olivia Hernández B.
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Magdalena Honorato S.
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María Carolina Silva G.
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Álvaro Sepúlveda-Martínez
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Javiera Fuenzalida C.
Scopus© Citations 9 5

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