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    A Third Dose of SARS-CoV-2 mRNA Vaccine Improves Immune Response in Chronic Kidney Disease Patients
    (2023)
    POLI HARLOWE, MARIA CECILIA BERTA  
    ;
    VIAL COX, MARIA CECILIA  
    ;
    REY JURADO, EMMA  
    ;
    Natalia González
    ;
    CORTES SALINAS, LINA JIMENA  
    <jats:p>Chronic kidney disease (CKD) patients have an increased risk of morbidity and mortality following SARS-CoV-2 infection. Vaccination in these patients is prioritized, and monitoring of the immune response is paramount to define further vaccination strategies. This prospective study included a cohort of 100 adult CKD patients: 48 with kidney transplant (KT) and 52 on hemodialysis without prior COVID-19. The patients were assessed for humoral and cellular immune responses after four months of an anti-SARS-CoV-2 primary two-dose vaccination scheme (CoronaVac or BNT162b2) and one month after a booster third dose of BNT162b2 vaccine. We identified poor cellular and humoral immune responses in the CKD patients after a primary vaccination scheme, and these responses were improved by a booster. Robust polyfunctional CD4+ T cell responses were observed in the KT patients after a booster, and this could be attributed to a higher proportion of the patients having been vaccinated with homologous BNT162b2 schemes. However, even after the booster, the KT patients exhibited lower neutralizing antibodies, attributable to specific immunosuppressive treatments. Four patients suffered severe COVID-19 despite three-dose vaccination, and all had low polyfunctional T-cell responses, underscoring the importance of this functional subset in viral protection. In conclusion, a booster dose of SARS-CoV-2 mRNA vaccine in CKD patients improves the impaired humoral and cellular immune responses observed after a primary vaccination scheme.</jats:p>
      8Scopus© Citations 5
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    El riñón del niño prematuro: riesgos a largo plazo
    (2020)
    Felipe Cavagnaro SM.
    <jats:p>El recién nacido prematuro se enfrenta a las condiciones extrauterinas con sistemas aún inmaduros, tanto anatómica como fisiológicamente. El riñón termina de desarrollarse a finales del tercer trimestre del embarazo, por lo que está especialmente expuesto a alterar su desarrollo normal en caso de nacer en forma prematura. Esta situación puede condicionar, entre otras consecuencias, una menor masa renal funcional y cambios microvasculares que representan un riesgo elevado de hipertensión arterial y daño renal crónico en el largo plazo. En el presente artículo se analiza la evidencia existente actual sobre estos riesgos en los prematuros y se ofrece un esquema de seguimiento de estos niños desde el punto de vista nefrológico.</jats:p>
      9Scopus© Citations 5
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    Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children
    (2016)
    Francisca Ugarte
    ;
    Carlos Irarrazabal
    ;
    Jun Oh
    ;
    Anne Dettmar
    ;
    María L. Ceballos
      10Scopus© Citations 8
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    Mineral metabolism in patients on chronic peritoneal dialysis [Metabolismo mineral en niños en diálisis peritoneal crónica]
    (2014)
    MARÍA LUISA CEBALLOS O
    ;
    ANGÉLICA ROJO L
    ;
    MARTA AZÓCAR P
    ;
    MARÍA JOSÉ IBACACHE M
    ;
    ANGELA DELUCCHI B
    Scopus© Citations 3  1