Universidad del Desarrollo

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Manejo del dolor agudo y crónico en pacientes ancianos
(Asociacion de Medicos Anestesiologos de Chile, 2024)
Josefina Yates
;
Martín Lacassie
;
Eduardo Vega Pérez
;
Antonia Cárdenas
;
Cristóbal Pedemonte
6
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Complicaciones neurológicas e infecciones tras analgesia neuroaxial del parto
(2022)
Héctor J. Lacassie
;
Martín Lacassie
;
Emilia Lacassie
2
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International perspective on healthcare provider gender bias in musculoskeletal pain management: a scoping review protocol
(2022)
Katherine Fisher Wilford
;
Maria Jesus Mena-Iturriaga
;
Margaret Vugrin
;
Macarena Wainer
;
Phillip S Sizer
<jats:sec><jats:title>Introduction</jats:title><jats:p>Chronic pain affects millions of individuals worldwide. Healthcare provider gender bias in the management of these individuals has societal and individual ramifications. Yet, a thorough and comprehensive literature summary on this topic is lacking. Therefore, this study aims to systematically: (1) identify and map the available scientific and grey literature as it relates to healthcare provider gender bias in the assessment, diagnosis and management of (chronic) musculoskeletal pain and (2) identify current gaps that necessitate further research.</jats:p></jats:sec><jats:sec><jats:title>Methods and analysis</jats:title><jats:p>This scoping review will be conducted in accordance with recent guidelines, and the results will be reported via the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. The following databases will be searched: PubMed (National Library of Medicine), Embase (Elsevier), Scopus (Elsevier), CINAHL Complete (Ovid), Academic Search Complete (Ebscohost), Pre-Prints Database (National Library of Medicine) and Rehabilitation Reference Center from inception to August 2022. Additionally, relevant grey literature will be identified. All screening will be done by two independent reviewers during two stages: first title/abstract screening followed by full-text screening. Data will be extracted from the bibliometric, study characteristics, and pain science families of variables. Results will be descriptively mapped, and the frequency of concepts, population, characteristics and other details will be narratively reported. Additionally, results will be presented in tabular and graphical form.</jats:p></jats:sec><jats:sec><jats:title>Ethics and dissemination</jats:title><jats:p>As this study will neither involve human subject participation nor utilisation of protected data, ethical approval is not required. This study’s methodological approach follows current recommendations. Study findings will be disseminated through conference presentations and international peer-review journal publication. In addition, infographics available in English, Spanish and German will be disseminated.</jats:p></jats:sec><jats:sec><jats:title>Registration details</jats:title><jats:p>This project will be registered in Open Science Framework prior to data collection.</jats:p></jats:sec>
17Scopus© Citations 1
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A Novel Morphine Drinking Model of Opioid Dependence in Rats
(2022)
BERRIOS CARCAMO, PABLO ANDRES
;
Mauricio Quezada
;
Daniela Santapau
;
Paola Morales
;
OLIVARES, MARIA BELEN
<jats:p>An animal model of voluntary oral morphine consumption would allow for a pre-clinical evaluation of new treatments aimed at reducing opioid intake in humans. However, the main limitation of oral morphine consumption in rodents is its bitter taste, which is strongly aversive. Taste aversion is often overcome by the use of adulterants, such as sweeteners, to conceal morphine taste or bitterants in the alternative bottle to equalize aversion. However, the adulterants’ presence is the cause for consumption choice and, upon removal, the preference for morphine is not preserved. Thus, current animal models are not suitable to study treatments aimed at reducing consumption elicited by morphine itself. Since taste preference is a learned behavior, just-weaned rats were trained to accept a bitter taste, adding the bitterant quinine to their drinking water for one week. The latter was followed by allowing the choice of quinine or morphine (0.15 mg/mL) solutions for two weeks. Then, quinine was removed, and the preference for morphine against water was evaluated. Using this paradigm, we show that rats highly preferred the consumption of morphine over water, reaching a voluntary morphine intake of 15 mg/kg/day. Morphine consumption led to significant analgesia and hyperlocomotion, and to a marked deprivation syndrome following the administration of the opioid antagonist naloxone. Voluntary morphine consumption was also shown to generate brain oxidative stress and neuroinflammation, signs associated with opioid dependence development. We present a robust two-bottle choice animal model of oral morphine self-administration for the evaluation of therapeutic interventions for the treatment of morphine dependence.</jats:p>
1Scopus© Citations 17
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Receptors involved in dexketoprofen analgesia in murine visceral pain
(2020)
V Noriega
;
F Sierralta
;
P Poblete
;
N Aranda
;
R Sotomayor-Zárate
52Scopus© Citations 2
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Terapia manual, un arma de doble filo en el manejo del dolor crónico.
(2018)
Iván Alejandro Cuyul Vásquez
;
Leonel Jaramillo
;
Nelson Adrian Serrano
2
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Solutions for the Unstable and Arthritic Distal Radioulnar Joint
(2020)
Juan Manuel Breyer
;
Pamela Vergara
30Scopus© Citations 1

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