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Psychiatric genetics in the diverse landscape of Latin American populations
(Springer Science and Business Media LLC, 2025-04-02)
Estela M. Bruxel
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Diego L. Rovaris
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Sintia I. Belangero
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Gabriela Chavarría-Soley
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Alfredo B. Cuellar-Barboza
4
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Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample
(Springer Science and Business Media LLC, 2025-03-24)
Kelly Allott
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Walid Yassin
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Luis Alameda
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Tashrif Billah
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Owen Borders
Scopus© Citations 5 7
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Montreal Cognitive Assessment (MoCA) as a screening tool for cognitive impairment in early stages of psychosis
(2024)
Sebastian Corral
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Pablo A. Gaspar
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Rolando I. Castillo-Passi
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Rocío Mayol Troncoso
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Adrian P. Mundt
Scopus© Citations 3 1
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Brain Network Architecture Intricately Linked to Morphological Abnormalities in Major Psychiatric Disorders
(2021)
Foivos Georgiadis
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Lariviere, Sara
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Vaughan Carr
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Stanley Catts
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Green, Melissa
1
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Paradoxical Expectation: Oscillatory Brain Activity Reveals Social Interaction Impairment in Schizophrenia
(2015)
BILLEKE BOBADILLA, PABLO ERNESTO
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Alejandra Armijo
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Daniel Castillo
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Tamara López
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ZAMORANO m, FRANCISCO JAVIER
Scopus© Citations 45 5
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Structural brain abnormalities in schizophrenia in adverse environments: examining the effect of poverty and violence in six Latin American cities
(2020)
Nicolas A. Crossley
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Andre Zugman
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Francisco Reyes-Madrigal
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Leticia S. Czepielewski
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Mariana N. Castro
<jats:title>Summary</jats:title><jats:sec id="S0007125020001439_sec_a1"><jats:title>Background</jats:title><jats:p>Social and environmental factors such as poverty or violence modulate the risk and course of schizophrenia. However, how they affect the brain in patients with psychosis remains unclear.</jats:p></jats:sec><jats:sec id="S0007125020001439_sec_a2"><jats:title>Aims</jats:title><jats:p>We studied how environmental factors are related to brain structure in patients with schizophrenia and controls in Latin America, where these factors are large and unequally distributed.</jats:p></jats:sec><jats:sec id="S0007125020001439_sec_a3" sec-type="methods"><jats:title>Method</jats:title><jats:p>This is a multicentre study of magnetic resonance imaging in patients with schizophrenia and controls from six Latin American cities. Total and voxel-level grey matter volumes, and their relationship with neighbourhood characteristics such as average income and homicide rates, were analysed with a general linear model.</jats:p></jats:sec><jats:sec id="S0007125020001439_sec_a4" sec-type="results"><jats:title>Results</jats:title><jats:p>A total of 334 patients with schizophrenia and 262 controls were included. Income was differentially related to total grey matter volume in both groups (<jats:italic>P</jats:italic> = 0.006). Controls showed a positive correlation between total grey matter volume and income (<jats:italic>R</jats:italic> = 0.14, <jats:italic>P</jats:italic> = 0.02). Surprisingly, this relationship was not present in patients with schizophrenia (<jats:italic>R</jats:italic> = −0.076, <jats:italic>P</jats:italic> = 0.17). Voxel-level analysis confirmed that this interaction was widespread across the cortex. After adjusting for global brain changes, income was positively related to prefrontal cortex volumes only in controls. Conversely, the hippocampus in patients with schizophrenia, but not in controls, was relatively larger in affluent environments. There was no significant correlation between environmental violence and brain structure.</jats:p></jats:sec><jats:sec id="S0007125020001439_sec_a5" sec-type="conclusions"><jats:title>Conclusions</jats:title><jats:p>Our results highlight the interplay between environment, particularly poverty, and individual characteristics in psychosis. This is particularly important for harsh environments such as low- and middle-income countries, where potentially less brain vulnerability (less grey matter loss) is sufficient to become unwell in adverse (poor) environments.</jats:p></jats:sec>
Scopus© Citations 10 1
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Abnormal nodal and global network organization in resting state functional MRI from subjects with the 22q11 deletion syndrome
(2021)
Teuntje A. D. Pelgrim
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Matthijs G. Bossong
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Analía Cuiza
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Luz María Alliende
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Carlos Mena
<jats:title>Abstract</jats:title><jats:p>The 22q11 deletion syndrome is a genetic disorder associated with a high risk of developing psychosis, and is therefore considered a neurodevelopmental model for studying the pathogenesis of schizophrenia. Studies have shown that localized abnormal functional brain connectivity is present in 22q11 deletion syndrome like in schizophrenia. However, it is less clear whether these abnormal cortical interactions lead to global or regional network disorganization as seen in schizophrenia. We analyzed from a graph-theory perspective fMRI data from 40 22q11 deletion syndrome patients and 67 healthy controls, and reconstructed functional networks from 105 brain regions. Between-group differences were examined by evaluating edge-wise strength and graph theoretical metrics of local (weighted degree, nodal efficiency, nodal local efficiency) and global topological properties (modularity, local and global efficiency). Connectivity strength was globally reduced in patients, driven by a large network comprising 147 reduced connections. The 22q11 deletion syndrome network presented with abnormal local topological properties, with decreased local efficiency and reductions in weighted degree particularly in hub nodes. We found evidence for abnormal integration but intact segregation of the 22q11 deletion syndrome network. Results suggest that 22q11 deletion syndrome patients present with similar aberrant local network organization as seen in schizophrenia, and this network configuration might represent a vulnerability factor to psychosis.</jats:p>
Scopus© Citations 2 1
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Mother’s mental health and the interaction with her moderate preterm baby in the NICU
(2022)
MIRA OLIVOS, ANDREA
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COO CALCAGNI, SOLEDAD
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Rodolfo Bastías
Scopus© Citations 8 10
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Intra and inter-individual variability in functional connectomes of patients with First Episode of Psychosis
(2023)
Ángeles Tepper
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Javiera Vásquez Núñez
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Juan Pablo Ramirez-Mahaluf
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Juan Manuel Aguirre
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Daniella Barbagelata
Scopus© Citations 1 2
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Updated clinical practice recommendations for managing adults with 22q11.2 deletion syndrome
(2023)
Erik Boot
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Sólveig Óskarsdóttir
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Joanne C.Y. Loo
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Terrence Blaine Crowley
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Ani Orchanian-Cheff
Scopus© Citations 76 2

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