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    Pediatric patients’ reasons for visiting dentists in all WHO regions
    (2021)
    Katrin Bekes
    ;
    Mike T. John
    ;
    Ksenija Rener-Sitar
    ;
    Mohammad H. Al-Harthy
    ;
    Ambra Michelotti
    <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Oral Function, Orofacial Pain, Orofacial Appearance, and Psychosocial Impact are the four oral health-related quality of life (OHRQoL) dimensions (4D) or areas in which oral disorders impact pediatric patients. Using their dentists' assessment, the study aimed to evaluate whether pediatric dental patients' oral health concerns fit into the 4D of the Oral Health-Related Quality of Life (OHRQoL) construct.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Dentists who treat children from 32 countries and all WHO regions were selected from a web-based survey of 1580 international dentists. Dentists were asked if their pediatric patients with current or future oral health concerns fit into the 4D of the Oral Health-Related Quality of Life (OHRQoL) construct. Proportions of all pediatric patients’ oral health problems and prevention needs were computed.</jats:p></jats:sec><jats:sec><jats:title>Findings</jats:title><jats:p>Data from 101 dentists treating children only and 523 dentists treating children and adults were included. For 90% of pediatric patients, their current oral health problems fit well in the four OHRQoL dimensions. For 91% of oral health problems they intended to prevent in the future were related to these dimensions as well. Both numbers increased to at least 96% when experts analyzed dentists´ explanations of why some oral health problems would not fit these four categories.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The study revealed the four fundamental components of dental patients, i.e., the four OHRQoL dimensions (Oral Function, Orofacial Pain, Orofacial Appearance, and Psychosocial Impact) are also applicable for pediatric patients, regardless of whether they have current or future oral health concerns, and should be considered when measuring OHRQoL in the pediatric dental patient population.</jats:p></jats:sec>
    Scopus© Citations 7  2
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    Modulatory Effect of Glycated Collagen on Oral Streptococcal Nanoadhesion
    (2020)
    SCHUH, CHRISTINA  
    ;
    B. Benso
    ;
    P.A. Naulin
    ;
    N.P. Barrera
    ;
    L. Bozec
    <jats:p> Biofilm-mediated oral diseases such as dental caries and periodontal disease remain highly prevalent in populations worldwide. Biofilm formation initiates with the attachment of primary colonizers onto surfaces, and in the context of caries, the adhesion of oral streptococci to dentinal collagen is crucial for biofilm progression. It is known that dentinal collagen suffers from glucose-associated crosslinking as a function of aging or disease; however, the effect of collagen crosslinking on the early adhesion and subsequent biofilm formation of relevant oral streptococci remains unknown. Therefore, the aim of this work was to determine the impact of collagen glycation on the initial adhesion of primary colonizers such as Streptococcus mutans UA159 and Streptococcus sanguinis SK 36, as well as its effect on the early stages of streptococcal biofilm formation in vitro. Type I collagen matrices were crosslinked with either glucose or methylglyoxal. Atomic force microscopy nanocharacterization revealed morphologic and mechanical changes within the collagen matrix as a function of crosslinking, such as a significantly increased elastic modulus in crosslinked fibrils. Increased nanoadhesion forces were observed for S. mutans on crosslinked collagen surfaces as compared with the control, and retraction curves obtained for both streptococcal strains demonstrated nanoscale unbinding behavior consistent with bacterial adhesin-substrate coupling. Overall, glucose-crosslinked substrates specifically promoted the initial adhesion, biofilm formation, and insoluble extracellular polysaccharide production of S. mutans, while methylglyoxal treatment reduced biofilm formation for both strains. Changes in the adhesion behavior and biofilm formation of oral streptococci as a function of collagen glycation could help explain the biofilm dysbiosis seen in older people and patients with diabetes. Further studies are necessary to determine the influence of collagen crosslinking on the balance between acidogenic and nonacidogenic streptococci to aid in the development of novel preventive and therapeutic treatment against dental caries in these patients. </jats:p>
      1Scopus© Citations 23  2
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    Antibacterial Effect of Honey-Derived Exosomes Containing Antimicrobial Peptides Against Oral Streptococci
    (2021)
    Camila Leiva-Sabadini
    ;
    Simon Alvarez
    ;
    Nelson P Barrera
    ;
    Christina MAP Schuh
    ;
    Sebastian Aguayo
    Scopus© Citations 39  3
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    Nanomechanical and Molecular Characterization of Aging in Dentinal Collagen
    (2022)
    C.M.A.P. Schuh
    ;
    C. Leiva-Sabadini
    ;
    S. Huang
    ;
    N.P. Barrera
    ;
    L. Bozec
    <jats:p> Methylglyoxal (MGO) is an important molecule derived from glucose metabolism with the capacity of attaching to collagen and generating advanced glycation end products (AGEs), which accumulate in tissues over time and are associated with aging and diseases. However, the accumulation of MGO-derived AGEs in dentin and their effect on the nanomechanical properties of dentinal collagen remain unknown. Thus, the aim of the present study was to quantify MGO-based AGEs in the organic matrix of human dentin as a function of age and associate these changes with alterations in the nanomechanical and ultrastructural properties of dentinal collagen. For this, 12 healthy teeth from &lt;26-y-old and &gt;50-y-old patients were collected and prepared to obtain crown and root dentin discs. Following demineralization, MGO-derived AGEs were quantified with a competitive ELISA. In addition, atomic force microscopy nanoindentation was utilized to measure changes in elastic modulus in peritubular and intertubular collagen fibrils. Finally, principal component analysis was carried out to determine aging profiles for crown and root dentin. Results showed an increased presence of MGO AGEs in the organic matrix of dentin in the &gt;50-y-old specimens as compared with the &lt;26-y-old specimens in crown and root. Furthermore, an increase in peritubular and intertubular collagen elasticity was observed in the &gt;50-y-old group associated with ultrastructural changes in the organic matrix as determined by atomic force microscopy analysis. Furthermore, principal component analysis loading plots suggested different “aging profiles” in crown and root dentin, which could have important therapeutic implications in restorative and adhesive dentistry approaches. Overall, these results demonstrate that the organic matrix of human dentin undergoes aging-related changes due to MGO-derived AGEs with important changes in the nanomechanical behavior of collagen that may affect diagnostic and restorative procedures in older people. </jats:p>
      5Scopus© Citations 7
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    Bacterial adhesion to collagens: implications for biofilm formation and disease progression in the oral cavity
    (2021)
    Simón Álvarez
    ;
    Camila Leiva-Sabadini
    ;
    Christina M. A. P. Schuh
    ;
    Sebastian Aguayo
    Scopus© Citations 26  4
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      12  1Scopus© Citations 21