Search Results

Now showing 1 - 3 of 3

Some of the metrics are blocked by your
consent settings
Effects of a High-Fat Diet and Docosahexaenoic Acid during Pregnancy on Fatty Acid Composition in the Fetal Livers of Mice
(2023)
Daniela Álvarez
;
Macarena Ortiz
;
Gabriel Valdebenito
;
Nicolás Crisosto
;
Bárbara Echiburú
<jats:p>A high-fat diet (HFD) during pregnancy promotes fat accumulation and reduces docosahexaenoic acid (DHA) levels in the liver of the offspring at postnatal ages, which can depend on fetal sex. However, the prenatal mechanisms behind these associations are still unclear. Thus, we analyzed if an HFD alters DHA content and the expression of molecules related to fatty acid (FA) metabolism in the fetal liver. Female C57BL/6 mice were fed a control diet or HFD for 4–6 weeks before pregnancy until the gestational day (GD) 17.5. A subgroup of each diet received DHA (100 mg/Kg) orally from GD 6.5 until 16.5. On GD 17.5, maternal livers, placentas, and livers from male and female fetuses were collected for FA profiling with gas-chromatography and gene expression of molecules related to FA metabolism using qPCR. PPAR-α protein expression was evaluated using Western blot. The gene expression of placental FA transporters was also assessed. An HFD increased eicosapentaenoic acid (EPA) and decreased DHA levels and protein expression of PPAR-α in the fetal livers of both sexes. DHA increased the gene expression of Ppara, Cpt1, and Acsl1 in the livers of female fetuses. Therefore, an HFD reduces DHA levels and PPAR-α, a master regulator of gene expression, in the fetal liver. In turn, the livers of female fetuses seem to be more sensitive to DHA action.</jats:p>
Scopus© Citations 2
Some of the metrics are blocked by your
consent settings
Association between maternal obesity, essential fatty acids and biomarkers of fetal liver function
(2023)
Macarena Ortiz
;
Francisca Sánchez
;
Daniela Álvarez
;
Cristian Flores
;
Francisca Salas-Pérez
7Scopus© Citations 5
Some of the metrics are blocked by your
consent settings
Brain structural parameters correlate with University Selection Test outcomes in Chilean high school graduates
(2022)
Daniza Ivanovic
;
ZAMORANO M, FRANCISCO JAVIER
;
SOTO ICAZA, PATRICIA
;
Tatiana Rojas
;
Atilio Almagià
<jats:title>Abstract</jats:title><jats:p>How well students learn and perform in academic contexts is a focus of interest for the students, their families, and the entire educational system. Although evidence has shown that several neurobiological factors are involved in scholastic achievement (SA), specific brain measures associated with academic outcomes and whether such associations are independent of other factors remain unclear. This study attempts to identify the relationship between brain structural parameters, and the Chilean national University Selection Test (PSU) results in high school graduates within a multidimensional approach that considers socio-economic, intellectual, nutritional, and demographic variables. To this end, the brain morphology of a sample of 102 students who took the PSU test was estimated using Magnetic Resonance Imaging. Anthropometric parameters, intellectual ability (IA), and socioeconomic status (SES) were also measured. The results revealed that, independently of sex, IA, gray matter volume, right inferior frontal gyrus thickness, and SES were significantly associated with SA. These findings highlight the role of nutrition, health, and socioeconomic variables in academic success.</jats:p>
Scopus© Citations 4 2

CRIS

Browse

Filters

Settings

Sort By

Results per page

Search Results