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A Tetrameric Peptide Derived from Bovine Lactoferricin Exhibits Specific Cytotoxic Effects against Oral Squamous-Cell Carcinoma Cell Lines
(2015)
Víctor A. Solarte
;
Jaiver E. Rosas
;
Zuly J. Rivera
;
Martha L. Arango-Rodríguez
;
Javier E. García
<jats:p>Several short linear peptides derived from cyclic bovine lactoferricin were synthesized and tested for their cytotoxic effect against the oral cavity squamous-cell carcinoma (OSCC) cell lines CAL27 and SCC15. As a control, an immortalized and nontumorigenic cell line, Het-1A, was used. Linear peptides based on the RRWQWR core sequence showed a moderate cytotoxic effect and specificity towards tumorigenic cells. A tetrameric peptide, LfcinB(20–25)<jats:sub>4</jats:sub>, containing the RRWQWR motif, exhibited greater cytotoxic activity (>90%) in both OSCC cell lines compared to the linear lactoferricin peptide or the lactoferrin protein. Additionally, this tetrameric peptide showed the highest specificity towards tumorigenic cells among the tested peptides. Interestingly, this effect was very fast, with cell shrinkage, severe damage to cell membrane permeability, and lysis within one hour of treatment. Our results are consistent with a necrotic effect rather than an apoptotic one and suggest that this tetrameric peptide could be considered as a new candidate for the therapeutic treatment of OSCC.</jats:p>
Scopus© Citations 33
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Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes
(2016)
FLAVIA ALEJANDRA BRUNA
;
CONTADOR MARTINEZ, DAVID ERNESTO
;
CONGET MOLINA, PAULETTE ANDREA
;
Benjamín Erranz
;
Claudia L. Sossa
<jats:p>Preclinical and clinical studies have shown that a therapeutic effect results from mesenchymal stromal cells (MSCs) transplant. No systematic information is currently available regarding whether donor age modifies MSC regenerative potential on cutaneous wound healing. Here, we evaluate whether donor age influences this potential. Two different doses of bone marrow MSCs (BM-MSCs) from young, adult, or old mouse donors or two doses of their acellular derivatives mesenchymal stromal cells (acd-MSCs) were intradermally injected around wounds in the midline of C57BL/6 mice. Every two days, wound healing was macroscopically assessed (wound closure) and microscopically assessed (reepithelialization, dermal-epidermal junction, skin appendage regeneration, granulation tissue, leukocyte infiltration, and density dermal collagen fibers) after 12 days from MSC transplant. Significant differences in the wound closure kinetic, quality, and healing of skin regenerated were observed in lesions which received BM-MSCs from different ages or their acd-MSCs compared to lesions which received vehicle. Nevertheless, our data shows that adult’s BM-MSCs or their acd-MSCs were the most efficient for recovery of most parameters analyzed. Our data suggest that MSC efficacy was negatively affected by donor age, where the treatment with adult’s BM-MSCs or their acd-MSCs in cutaneous wound promotes a better tissue repair/regeneration. This is due to their paracrine factors secretion.</jats:p>
1Scopus© Citations 41 1
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Suicide HSVtk Gene Delivery by Neurotensin-Polyplex Nanoparticles via the Bloodstream and GCV Treatment Specifically Inhibit the Growth of Human MDA-MB-231 Triple Negative Breast Cancer Tumors Xenografted in Athymic Mice
(2014)
Rosa A. Castillo-Rodríguez
;
Martha L. Arango-Rodríguez
;
Lourdes Escobedo
;
Daniel Hernandez-Baltazar
;
Anne Gompel
9Scopus© Citations 26
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The role of bone marrow mesenchymal stromal cell derivatives in skin wound healing in diabetic mice
(2017)
Tomas de Mayo
;
CONGET MOLINA, PAULETTE ANDREA
;
Silvia Becerra-Bayona
;
Claudia L. Sossa
;
Virgilio Galvis
Scopus© Citations 65 6

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