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Concordance of Helicobacter pylori Detection Methods in Symptomatic Children and Adolescents
(MDPI AG, 2025-03-04)
Camila Cabrera
;
Yanira Campusano
;
Joaquín Torres
;
Dinka Ivulic
;
Valeria Galvez
Background: Helicobacter pylori is the most prevalent chronic bacterial infection globally, acquired mostly during childhood. It is associated with chronic gastritis, peptic ulcer disease, and gastric cancer. Due to challenges in culturing H. pylori, diagnostic reference standards often rely on combining ≥2 non-culture, biopsy-based methods. Histology with Giemsa staining is widely used in clinical settings due to its low cost and reliable performance. Methods: This study evaluated the concordance between histology with Giemsa staining as the reference standard and other diagnostic methods, including the rapid urease test (RUT), ureA RT-PCR, 16S sequencing, and anti-H. pylori serum IgG. Positive percent of agreement (PPA), negative percent of agreement (NPA) and concordance kappa index were calculated. Results: A total of 120 patients (41 positive and 79 negative by Giemsa staining) were analyzed. Among the methods tested, RT-PCR for ureA showed the best performance (PPA = 94.7%, NPA = 98.6%, kappa = 0.939), while RUT underperformed compared with expectations (PPA = 65.9%, NPA = 97.5%, kappa = 0.681). Serology had the lowest performance (PPA = 53.7%, NPA = 96.1%, kappa = 0.548). Conclusions: The combination of histology with Giemsa staining and ureA RT-PCR achieved the highest detection rate and strongest agreement.</jats:p>
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Satisfacción escolar y bienestar subjetivo en la adolecencia: poniendo a prueba indicadores para su medición comparativa en Brasil, Chile y España
(2014)
Ferran Casas
;
Jorge C. Sarriera
;
ALFARO INZUNZA, JAIME ANDRES
;
Mónica González
;
Cristina Figueroa
2Scopus© Citations 34
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Effect of
<i>Helicobacter pylori</i>
eradication therapy on clinical and laboratory biomarkers associated with gastric damage in healthy school‐aged children: A randomized non‐blinded trial
(2021)
LUCERO, YALDA
;
Anne J. Lagomarcino
;
Juan P. Torres
;
ROESSLER VERGARA, PATRICIA ANDREA
;
Nora Mamani
1 1Scopus© Citations 13
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Corrigendum: Helicobacter pylori cagA+ Is Associated with Milder Duodenal Histological Changes in Chilean Celiac Patients
(2017)
YALDA CECILIA LUCERO ALVAREZ
;
Amaya Oyarzún
;
Miguel O'Ryan
;
Rodrigo Quera
;
Nelly Espinosa
9Scopus© Citations 1
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Presurgical evaluation of temporal lobe epilepsy: Is an outpatient prolonged ambulatory EEG study sufficient to recommend a surgical resection?
(2020)
Ada Chicharro
;
Alejandro de Marinis
;
Anna Milán
;
Daniel Mansilla
;
Alberto Prat
11Scopus© Citations 4

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