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Author: search.filters.author.Christina M. A. P. SchuhSubject: search.filters.subject.apis mellifera

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    Item type:Publication,
    Type I collagen hydrogels as a delivery matrix for royal jelly derived extracellular vesicles
    (2020)
    Orlando J. Ramírez
    ;
    Simón Alvarez
    ;
    Pamina Contreras-Kallens
    ;
    Nelson P. Barrera
    ;
    Sebastian Aguayo
      7Scopus© Citations 34
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    Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity
    (2019)
    Christina M. A. P. Schuh
    ;
    Sebastian Aguayo
    ;
    Gabriela Zavala
    ;
    Maroun Khoury
    <jats:p>Microvesicles have become key players in cellular communication. Since glandular secretions present a rich source of active exosomes, we hypothesized that exosome-like vesicles are present in Apis mellifera hypopharyngeal gland secretomal products (honey, royal jelly and bee pollen), and participate in their known antibacterial and pro-regenerative effects. We developed an isolation protocol based on serial- and ultracentrifugation steps and demonstrated the presence of protein-containing exosome-like vesicles in all three bee-derived products. Assessing their antibacterial properties, we found that exosome-like vesicles had bacteriostatic, bactericidal and biofilm-inhibiting effects on Staphylococcus aureus. Furthermore, we could demonstrate that mesenchymal stem cells (MSCs) internalize bee-derived exosome-like vesicles and that these vesicles influence their migration potential. In an in vitro wound healing assay, honey and royal jelly exosome-like vesicles increased migration of human MSC, demonstrating their interkingdom activity. Summarizing, we have discovered exosome-like vesicles as a new, active compound in bee pollen, honey and royal jelly.</jats:p>
    Scopus© Citations 49  1