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Item type:Publication, A liaR Deletion Restores Susceptibility to Daptomycin and Antimicrobial Peptides in Multidrug-Resistant Enterococcus faecalis(2014) ;Jinnethe Reyes ;Diana Panesso ;Truc T. Tran ;Nagendra N. MishraMelissa R. Cruz7 1Scopus© Citations 82 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Failure of High-Dose Daptomycin for Bacteremia Caused by Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions(2014); ;Nagendra N. Mishra ;Danya Alvarez ;Truc T. TranLorena Diaz13 1Scopus© Citations 57 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Daptomycin for the treatment of bacteraemia due to vancomycin-resistant enterococci(2014); ;Barbara E. MurrayCesar A. Arias12Scopus© Citations 39 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Influence of Inoculum Effect on the Efficacy of Daptomycin Monotherapy and in Combination with beta-Lactams against Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions(2018) ;Razieh Kebriaei ;Seth A. Rice ;Kavindra V. Singh ;Kyle C. StamperAn Q. Dinh<jats:p> <jats:named-content content-type="genus-species">Enterococcus faecium</jats:named-content> isolates that harbor LiaFSR substitutions but are phenotypically susceptible to daptomycin (DAP) by current breakpoints are problematic, since predisposition to resistance may lead to therapeutic failure. Using a simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic (PK/PD) model, we investigated DAP regimens (6, 8, and 10 mg/kg of body weight/day) as monotherapy and in combination with ampicillin (AMP), ceftaroline (CPT), or ertapenem (ERT) against <jats:named-content content-type="genus-species">E. faecium</jats:named-content> HOU503, a DAP-susceptible strain that harbors common LiaS and LiaR substitutions found in clinical isolates (T120S and W73C, respectively). </jats:p>3 1Scopus© Citations 37