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Dataset - Semantic memory navigation in mild cognitive impairment: Automated markers with neural and biofluid correlates
(GITHUB, 2026)
SLACHEVSKY CHONCHOL, ANDREA MARÍA
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Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America
(Wiley, 2026-06)
Farombi, Temitope
;
Azzi, Tiago
;
Legaz, Agustina
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Aguillón, David
;
Avila‐Funes, José Alberto
INTRODUCTION Adverse social conditions across the life course influence brain aging and dementia, yet their compounded impact on clinical phenotypes remains underexplored, particularly in Latin America, where social inequality and dementia burden are high. METHODS We studied 3941 individuals from six Latin American countries, including cognitively unimpaired controls (CU), Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD). A life‐course questionnaire captured eight domains of social vulnerability, used to derive a social vulnerability index and latent vulnerability profiles. Brain health was characterized across 37 cognitive, functional, mental health, and dementia severity indicators. RESULTS Higher vulnerability was mostly associated with executive and memory deficits in CU, cognitive and functional impairment in AD, and social cognition and neuropsychiatric symptoms in FTLD. Multidimensional brain health was affected across groups. DISCUSSION Compounded social vulnerability is a key determinant of clinical expression in aging and dementia, underscoring the need for life‐course–informed and equity‐oriented dementia models.
4Scopus© Citations 1
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Mapping the neurovascular landscape in aging and dementia: cerebral small vessel disease markers in a multicenter Latin American cohort
(Wiley, 2026-05)
Altschuler, Florencia
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Castro‐Laguardia, Ana Maria
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Canziani, Verónica
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O'Byrne, Daniel Franco
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Hazelton, Jessica
INTRODUCTION Cerebral small vessel disease (CSVD) is a key contributor to cognitive impairment and dementia, yet few studies have compared CSVD across dementia variants, particularly in underrepresented populations. METHODS In a multicenter cross‐sectional study, we analyzed magnetic resonance imaging (MRI) markers of CSVD, including white matter hyperintensities (WMHs), lacunes, and cerebral microbleeds, along with cardiometabolic risk factors and cognitive performance using regression models in 1675 participants (790 healthy controls, 642 with Alzheimer's disease [AD], and 243 with frontotemporal dementia [FTD]) from six Latin American countries. RESULTS AD showed the greatest CSVD burden, whereas FTD exhibited an intermediate profile driven by elevated WMHs. Blood pressure and smoking were the strongest correlates of WMHs, while diabetes was associated with microbleeds. WMH burden was linked to global and domain‐specific cognitive impairment. DISCUSSION This first large‐cohort Latin American study identifies WMHs as a key vascular substrate of cognitive impairment, with AD showing the greatest CSVD burden.
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Semantic memory navigation in mild cognitive impairment: Automated markers with neural and biofluid correlates
(Elsevier BV, 2026-09)
Pérez, Gonzalo
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Caro, Iván
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Ponferrada, Joaquín
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Ferrante, Franco J.
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Valdés, Joaquín
2
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Dataset - Plasma ATN biomarkers across the alzheimer's disease continuum in a Chilean community- and clinic-based cohort
(GITHUB, 2026)
SLACHEVSKY CHONCHOL, ANDREA MARÍA
1
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Dataset - Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America
(github, 2026)
BEHRENS PELLEGRINO, MARIA ISABEL
;
SLACHEVSKY CHONCHOL, ANDREA MARÍA
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Dataset - Benchmarking speech biomarkers of Alzheimer's against cognitive and neural measures
(OSF, 2026)
SLACHEVSKY CHONCHOL, ANDREA MARÍA
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Dataset - The exposome of brain aging across 34 countries
(OSF, 2026)
SLACHEVSKY CHONCHOL, ANDREA MARÍA
;
BEHRENS PELLEGRINO, MARIA ISABEL
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Dataset - The neuroactive potential of the elderly human gut microbiome is associated with mental health status
(ENA European Nucleotide Archive, 2026)
SLACHEVSKY CHONCHOL, ANDREA MARÍA
1
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Dataset - Loss in Old Age: The Role of Sociodemographic and Cognitive Factors
(University of Chile, 2025)
SLACHEVSKY CHONCHOL, ANDREA MARÍA

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