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Item type:Publication, Pulmonary Angiopathy in Severe COVID-19: Physiological Conclusions Derived from Ventilatory Ratio?(2021); 4Scopus© Citations 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effect of positive end-expiratory pressure on lung injury and haemodynamics during experimental acute respiratory distress syndrome treated with extracorporeal membrane oxygenation and near-apnoeic ventilation(2021)Scopus© Citations 11 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Outcomes of Sepsis and Septic Shock in Cancer Patients: Focus on Lactate(2021); Scopus© Citations 18 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Successful use of mild therapeutic hypothermia as compassionate treatment for severe refractory hypoxemia in COVID-19(2021)2Scopus© Citations 13 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Adverse Events of Prone Positioning in Mechanically Ventilated Adults With ARDS(2021)6Scopus© Citations 30 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Successful extracorporeal membrane oxygenation therapy in a child with coronavirus 2019 disease-associated ARDS and chemotherapy for Ewing’s sarcoma(2022); 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Extracorporeal Membrane Oxygenation for COVID-19–associated Severe Acute Respiratory Distress Syndrome in Chile: A Nationwide Incidence and Cohort Study(2021); Scopus© Citations 64 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pediatric Critical Care and COVID-19(2020)Scopus© Citations 80 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Continuous prolonged prone positioning in COVID-19-related ARDS: a multicenter cohort study from Chile(2022); Leyla Alegría<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Prone positioning is currently applied in time-limited daily sessions up to 24 h which determines that most patients require several sessions. Although longer prone sessions have been reported, there is scarce evidence about the feasibility and safety of such approach. We analyzed feasibility and safety of a continuous prolonged prone positioning strategy implemented nationwide, in a large cohort of COVID-19 patients in Chile.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Retrospective cohort study of mechanically ventilated COVID-19 patients with moderate-to-severe acute respiratory distress syndrome (ARDS), conducted in 15 Intensive Care Units, which adhered to a national protocol of continuous prone sessions ≥ 48 h and until PaO<jats:sub>2</jats:sub>:FiO<jats:sub>2</jats:sub> increased above 200 mm Hg. The number and extension of prone sessions were registered, along with relevant physiologic data and adverse events related to prone positioning. The cohort was stratified according to the first prone session duration: Group A, 2–3 days; Group B, 4–5 days; and Group C, > 5 days. Multivariable regression analyses were performed to assess whether the duration of prone sessions could impact safety.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>We included 417 patients who required a first prone session of 4 (3–5) days, of whom 318 (76.3%) received only one session. During the first prone session the main adverse event was grade 1–2 pressure sores in 97 (23.9%) patients; severe adverse events were infrequent with 17 non-scheduled extubations (4.2%). 90-day mortality was 36.2%. Ninety-eight patients (24%) were classified as group C; they exhibited a more severe ARDS at baseline, as reflected by lower PaO<jats:sub>2</jats:sub>:FiO<jats:sub>2</jats:sub> ratio and higher ventilatory ratio, and had a higher rate of pressure sores (44%) and higher 90-day mortality (48%). However, after adjustment for severity and several relevant confounders, prone session duration was not associated with mortality or pressure sores.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Nationwide implementation of a continuous prolonged prone positioning strategy for COVID-19 ARDS patients was feasible. Minor pressure sores were frequent but within the ranges previously described, while severe adverse events were infrequent. The duration of prone session did not have an adverse effect on safety.</jats:p> </jats:sec>Scopus© Citations 17 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Cardiac function in critically ill patients with severe COVID: A prospective cross-sectional study in mechanically ventilated patients(2022)Scopus© Citations 6 64