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    Development and validation of a questionnaire on perception of portfolio by undergraduate medical students
    (2011)
    CARLA BENAGLIO VEDOVELLI
    ;
    Arnoldo Riquelme
    ;
    Benjamin Mendez
    ;
    PALOMA DE LA FUENTE
    ;
    OSLANDO PADILLA
      4Scopus© Citations 9
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    Item type:Publication,
      21Scopus© Citations 5
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    Scopus© Citations 8  4
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    Socioeconomic factors associated with antimicrobial resistance of Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli in Chilean hospitals (2008–2017)
    (2020)
    Kasim Allel
    ;
    Patricia García
    ;
    Jaime Labarca
    ;
    ;
    Magdalena Rendic
    To identify socioeconomic factors associated with antimicrobial resistance of Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli in Chilean hospitals (2008–2017).</p> <p><bold>Methods.</bold> We reviewed the scientific literature on socioeconomic factors associated with the emergence and dissemination of antimicrobial resistance. Using multivariate regression, we tested findings from the literature drawing from a longitudinal dataset on antimicrobial resistance from 41 major private and public hospitals and a nationally representative household survey in Chile (2008–2017). We estimated resistance rates for three priority antibiotic–bacterium pairs, as defined by the Organisation for Economic Co-operation and Development; i.e., imipenem and meropenem resistant P. aeruginosa, cloxacillin resistant S. aureus, and cefotaxime and ciprofloxacin resistant E. coli.</p> <p><bold>Results.</bold> Evidence from the literature review suggests poverty and material deprivation are important risk factors for the emergence and transmission of antimicrobial resistance. Most studies found that worse socioeconomic indicators were associated with higher rates of antimicrobial resistance. Our analysis showed an overall antimicrobial resistance rate of 32.5%, with the highest rates for S. aureus (40.6%) and the lowest for E. coli (25.7%). We found a small but consistent negative association between socioeconomic factors (income, education, and occupation) and overall antimicrobial resistance in univariate (p &lt; 0.01) and multivariate analyses (p &lt; 0.01), driven by resistant P. aeruginosa and S. aureus.</p> <p><bold>Conclusion.</bold> Socioeconomic factors beyond health care and hospital settings may affect the emergence and dissemination of antimicrobial resistance. Preventing and controlling antimicrobial resistance requires efforts above and beyond reducing antibiotic consumption.
      3Scopus© Citations 29
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    Item type:Publication,
      7  1
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    Item type:Publication,
    Cluster of Imported Vivax Malaria in Travelers Returning From Peru
    (2015) ;
    Jaime Labarca
    ;
    Claudia P. Cortes
    ;
    Reinaldo Rosas
    ;
    M. Elvira Balcells
      4Scopus© Citations 3
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    A Prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenonnics of Staphylococcus aureus Bacterennia in Nine Latin American Countries
    (2017)
    Cesar A. Arias
    ;
    Jinnethe Reyes
    ;
    Lina Paola Carvajal
    ;
    Sandra Rincon
    ;
    Lorena Diaz
    <jats:title>ABSTRACT</jats:title> <jats:p> <jats:named-content content-type="genus-species">Staphylococcus aureus</jats:named-content> is an important pathogen causing a spectrum of diseases ranging from mild skin and soft tissue infections to life-threatening conditions. Bloodstream infections are particularly important, and the treatment approach is complicated by the presence of methicillin-resistant <jats:named-content content-type="genus-species">S. aureus</jats:named-content> (MRSA) isolates. The emergence of new genetic lineages of MRSA has occurred in Latin America (LA) with the rise and dissemination of the community-associated USA300 Latin American variant (USA300-LV). Here, we prospectively characterized bloodstream MRSA recovered from selected hospitals in 9 Latin American countries. All isolates were typed by pulsed-field gel electrophoresis (PFGE) and subjected to antibiotic susceptibility testing. Whole-genome sequencing was performed on 96 MRSA representatives. MRSA represented 45% of all (1,185 <jats:named-content content-type="genus-species">S. aureus</jats:named-content> ) isolates. The majority of MRSA isolates belonged to clonal cluster (CC) 5. In Colombia and Ecuador, most isolates (≥72%) belonged to the USA300-LV lineage (CC8). Phylogenetic reconstructions indicated that MRSA isolates from participating hospitals belonged to three major clades. Clade A grouped isolates with sequence type 5 (ST5), ST105, and ST1011 (mostly staphylococcal chromosomal cassette <jats:italic>mec</jats:italic> [SCC <jats:italic>mec</jats:italic> ] I and II). Clade B included ST8, ST88, ST97, and ST72 strains (SCC <jats:italic>mec</jats:italic> IV, subtypes a, b, and c/E), and clade C grouped mostly Argentinian MRSA belonging to ST30. In summary, CC5 MRSA was prevalent in bloodstream infections in LA with the exception of Colombia and Ecuador, where USA300-LV is now the dominant lineage. Clonal replacement appears to be a common phenomenon, and continuous surveillance is crucial to identify changes in the molecular epidemiology of MRSA. </jats:p>
      7  1Scopus© Citations 101