Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress self‐perpetuation - Yedy Israel; María Elena Quintanilla; EZQUER, EDUARDO FERNANDO; Paola Morales; Daniela Santapau; BERRIOS CARCAMO, PABLO ANDRES; EZQUER, EDUARDO MARCELO; OLIVARES, MARIA BELEN; Mario Herrera‐Marschitz (My University, 2019)
Keywords: acetylsalicylic acid; asa; astrocytosis; glutamate; microglia; oxidative stress; acetylcysteine; alcohol drinking; alcoholism; animals; anti-inflammatory agents, non-steroidal; aspirin; binge drinking; chronic disease; ethanol; excitatory amino acid transporter 2; female; oxidative stress; rats; recurrence; self administration; acetylcysteine; acetylsalicylic acid; alcohol; calcium binding protein; cystine; glial fibrillary acidic protein; glutamic acid; ionized calcium binding adaptor molecule 1; unclassified drug; vesicular glutamate transporter 1; acetylcysteine; acetylsalicylic acid; alcohol; excitatory amino acid transporter 2; nonsteroid antiinflammatory agent; adult; albumin blood level; alcohol blood level; alcohol consumption; alcoholism; amino acid transport; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; article; astrocyte; astrocytosis; behavior; binge drinking; combination chemotherapy; controlled study; drug potentiation; enzyme activity; female; hippocampal neuronal culture; immunoreactivity; low drug dose; microglia; monotherapy; nervous system inflammation; nonhuman; oxidative stress; prefrontal cortex; presynaptic inhibition; priority journal; rat; relapse; self perpetuation; treatment duration; wistar rat; alcoholism; animal; binge drinking; chronic disease; drinking behavior; drug effect; drug self administration; oxidative stress; recurrent disease