MUNITA SEPULVEDA, JOSE MANUELJOSE MANUELMUNITA SEPULVEDATruc T. TranLorena DiazDiana PanessoJinnethe ReyesBarbara E. MurrayCesar A. Arias2024-05-072024-05-072013http://hdl.handle.net/11447/1164https://investigadores.udd.cl/handle/123456789/922710.1128/AAC.00021-132-s2.0-84877854867WOS:000319272100052The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.Resource Types::text::journal::journal article